Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157969 - 157969
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Materials, Год журнала: 2023, Номер 35(52)
Опубликована: Апрель 23, 2023
Advances in bioprinting have enabled the fabrication of complex tissue constructs with high speed and resolution. However, there remains significant structural biological complexity within tissues that is unable to recapitulate. Bone, for example, has a hierarchical organization ranging from molecular whole organ level. Current techniques materials employed imposed limits on scale, speed, resolution can be achieved, rendering technique reproduce hierarchies cell-matrix interactions are observed bone. The shift toward biomimetic approaches bone engineering, where hydrogels provide biophysical biochemical cues encapsulated cells, promising approach enhancing function development vitro modeling. A major focus modeling creating dynamic microenvironmental niches support, stimulate, direct cellular processes formation remodeling. Hydrogels ideal imitating extracellular matrix since they engineered present various whilst allowing bioprinting. Here, recent advances 3D niche conducive engineering models reviewed.
Язык: Английский
Процитировано
45
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(2)
Опубликована: Июль 26, 2022
Abstract Tissue engineering (TE) is currently considered a cutting‐edge discipline that offers the potential for developing treatments health conditions negatively affect quality of life. This interdisciplinary field typically involves combination cells, scaffolds, and appropriate induction factors regeneration repair damaged tissue. Cell fate decisions, such as survival, proliferation, or differentiation, critically depend on various biochemical biophysical provided by extracellular environment during developmental, physiological, pathological processes. Therefore, understanding mechanisms action these critical to accurately mimic complex architecture living tissues improve efficiency TE approaches. In this review, we recapitulate effects have aspects cell fate. While role factors, growth small molecules, matrix (ECM) components, cytokines, has been extensively studied in context applications, it only recently begun understand signals surface topography, mechanical, electrical signals. These cues could provide more robust set stimuli manipulate signaling pathways formation engineered Furthermore, simultaneous application different types appears elicit synergistic responses are likely functional outcomes, which help translate results into successful clinical therapies future.
Язык: Английский
Процитировано
38
Bioactive Materials, Год журнала: 2023, Номер 28, С. 284 - 310
Опубликована: Июнь 1, 2023
Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells body determines fate of healing or inflammation. Although several reports have demonstrated that regeneration depends on spatial temporal regulation biophysical biochemical microenvironment biomaterial, underlying molecular mechanism behind still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated platforms reported literature show regenerative capabilities a particular tissue, example, endogenous (e.g., bone, muscle, heart, kidney, lungs) exogenous skin eye). In this review, we briefly introduced necessity 3D scaffolds nanomaterials, focusing material properties their interaction with macrophages general readers. This review also provides comprehensive summary origin taxonomy, diverse functions, various signal transduction pathways during biomaterial-macrophage interaction, which particularly helpful scientists clinicians next-generation From clinical standpoint, discussed role biomaterial and/or nanomaterial composites macrophage-assisted engineering special focus bone associated tissues. Finally, expert opinion presented to address challenges future bioprinted materials engineering.
Язык: Английский
Процитировано
27
Biomaterials and Biosystems, Год журнала: 2024, Номер 15, С. 100097 - 100097
Опубликована: Июль 8, 2024
While the extracellular matrix (ECM) has long been recognized for its structural contributions, anchoring cells adhesion, providing mechanical support, and maintaining tissue integrity, recent efforts have elucidated dynamic, reciprocal, diverse properties on angiogenesis. The ECM modulates angiogenic signaling transduction, influences extent degree of receptor activation, controls cellular behaviors, serves as a reservoir bioactive macromolecules. Collectively, these factors guide formation, maturation, stabilization functional vascular network. This review aims to shed light versatile roles in angiogenesis, transcending traditional functions mere material. We will explore engagement synergy modulation, interactions with various factors, highlight importance both health disease. By capturing essence ECM's functionalities, we significance broader context biology, enabling design novel biomaterials engineer vascularized tissues their potential therapeutic implications.
Язык: Английский
Процитировано
14
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)
Опубликована: Июль 18, 2023
The healing of infected bone defects (IBD) is a complex physiological process involving series spatially and temporally overlapping events, including pathogen clearance, immunological modulation, vascularization, osteogenesis. Based on the theory that regulated by both biochemical biophysical signals, in this study, copper doped bioglass (CuBGs)/methacryloyl-modified gelatin nanoparticle (MA-GNPs)/methacrylated silk fibroin (SilMA) hybrid hydrogel developed to promote IBD healing. This demonstrates dual-photocrosslinked interpenetrating network mechanism, wherein photocrosslinked SilMA as main ensures structural integrity, MA-GNPs colloidal increases strength dissipates loading forces. In an model, exhibits excellent characteristics, such adhesion, adaptation irregular defect shapes, situ physical reinforcement. At same time, sequentially releasing bioactive ions Cu2+ , Ca2+ Si2+ from CuBGs demand, spatiotemporally coordinates antibacterial, immunomodulatory remodeling efficiently removing infection accelerating repair without use antibiotics or exogenous recombinant proteins. Therefore, can be used simple effective method for treatment IBD.
Язык: Английский
Процитировано
20
Biomedical Materials, Год журнала: 2023, Номер 18(5), С. 052005 - 052005
Опубликована: Июль 21, 2023
Abstract The field of neural tissue engineering has undergone a revolution due to advancements in three-dimensional (3D) printing technology. This technology now enables the creation intricate constructs with precise geometries, topologies, and mechanical properties. Currently, there are various 3D techniques available, such as stereolithography digital light processing, wide range materials can be utilized, including hydrogels, biopolymers, synthetic materials. Furthermore, development four-dimensional (4D) gained traction, allowing for fabrication structures that change shape over time using shape-memory polymers. These innovations have potential facilitate regeneration, drug screening, disease modeling, hold tremendous promise personalized diagnostics, therapeutic strategies against brain cancers. review paper provides comprehensive overview current state-of-the-art cancer. It focuses on exciting possibilities lie ahead, emerging 4D printing. Additionally, discusses applications five-dimensional six-dimensional printing, which integrate biological functions into process, fields neuroscience.
Язык: Английский
Процитировано
16
Experimental Cell Research, Год журнала: 2023, Номер 431(2), С. 113766 - 113766
Опубликована: Сен. 7, 2023
Язык: Английский
Процитировано
16
Advanced Materials, Год журнала: 2024, Номер 36(33)
Опубликована: Июнь 6, 2024
The growing aging population, with its associated chronic diseases, underscores the urgency for effective tissue regeneration strategies. Biomaterials play a pivotal role in realm of reconstruction and regeneration, distinct shift toward minimally invasive (MI) treatments. This transition, fueled by engineered biomaterials, steers away from surgical procedures to embrace approaches offering reduced trauma, accelerated recovery, cost-effectiveness. In MI repair cargo delivery, various techniques are explored. While situ polymerization is prominent, it not without challenges. narrative review explores diverse fabrication methods, biofunctionalization injectable pre-formed scaffolds, focusing on their unique advantages. exhibiting compressibility, controlled injection, maintained mechanical integrity, emerge as promising alternative solutions conclusion this emphasizes importance interdisciplinary design facilitated synergizing fields materials science, advanced 3D biomanufacturing, mechanobiological studies, innovative regeneration.
Язык: Английский
Процитировано
7
Small, Год журнала: 2024, Номер 20(23)
Опубликована: Янв. 10, 2024
Abstract Musculoskeletal (MSK) disorders significantly burden patients and society, resulting in high healthcare costs productivity loss. These are the leading cause of physical disability, their prevalence is expected to increase as sedentary lifestyles become common global population elderly increases. Proper innervation critical maintaining MSK function, nerve damage or dysfunction underlies various disorders, underscoring potential restoring function disorder treatment. However, most tissue engineering strategies have overlooked significance innervation. This review first expounds upon system its importance homeostasis functions. will be followed by for tissues that induce post‐implantation situ pre‐innervated. Subsequently, research progress modeling using innervated organoids organs‐on‐chips (OoCs) analyzed. Finally, future development treat recapitulate disease mechanisms discussed. provides valuable insights into underlying principles, methods, applications tissues, paving way targeted, efficacious therapies conditions.
Язык: Английский
Процитировано
6
Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102635 - 102635
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
0