Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 29, 2025
N7-methylguanosine
(m7G)
is
an
important
RNA
modification
involved
in
epigenetic
regulation
that
commonly
observed
both
prokaryotic
and
eukaryotic
organisms.
Their
influence
on
the
synthesis
processing
of
messenger
RNA,
ribosomal
transfer
allows
m7G
modifications
to
affect
diverse
cellular,
physiological,
pathological
processes.
are
pivotal
human
diseases,
particularly
cancer
progression.
On
one
hand,
modification-associated
modulate
tumour
progression
malignant
biological
characteristics,
including
sustained
proliferation
signalling,
resistance
cell
death,
activation
invasion
metastasis,
reprogramming
energy
metabolism,
genome
instability,
immune
evasion.
This
suggests
they
may
be
novel
therapeutic
targets
for
treatment.
other
aberrant
expression
molecules
linked
clinicopathological
staging,
lymph
node
unfavourable
prognoses
patients
with
cancer,
indicating
their
potential
as
biomarkers.
review
consolidates
discovery,
identification,
detection
methodologies,
functional
roles
modification,
analysing
mechanisms
by
which
contribute
development,
exploring
clinical
applications
diagnostics
therapy,
thereby
providing
innovative
strategies
identification
targeted
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 27, 2025
Abstract
Methyltransferase-like
1
(METTL1)-mediated
m7G
modification
is
a
common
occurrence
in
various
RNA
species,
including
mRNAs,
tRNAs,
rRNAs,
and
miRNAs.
Recent
evidence
suggests
that
this
linked
to
the
development
of
several
cancers,
making
it
promising
target
for
cancer
therapy.
However,
specific
role
cutaneous
squamous
cell
carcinoma
(cSCC)
not
well
understood.
In
study,
we
observed
conspicuously
elevated
levels
METTL1
cSCC
tumors
lines.
Inhibiting
led
reduced
survival,
migration,
invasion,
xenograft
tumor
growth
cells.
Mechanistically,
through
combination
sequencing,
methylated
immunoprecipitation
(MeRIP)-qPCR,
mRNA
stability
assays,
discovered
responsible
ATF4
mRNA,
leading
increased
expression
ATF4.
Importantly,
demonstrated
dependent
on
methyltransferase
activity
METTL1.
Additionally,
positive
association
between
tumors.
Intriguingly,
restoring
cells
only
promoted
glycolysis
but
also
reversed
anti-tumor
effects
knockdown.
conclusion,
our
results
underscore
critical
tumorigenesis,
suggesting
future
therapies.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 29, 2025
N7-methylguanosine
(m7G)
is
an
important
RNA
modification
involved
in
epigenetic
regulation
that
commonly
observed
both
prokaryotic
and
eukaryotic
organisms.
Their
influence
on
the
synthesis
processing
of
messenger
RNA,
ribosomal
transfer
allows
m7G
modifications
to
affect
diverse
cellular,
physiological,
pathological
processes.
are
pivotal
human
diseases,
particularly
cancer
progression.
On
one
hand,
modification-associated
modulate
tumour
progression
malignant
biological
characteristics,
including
sustained
proliferation
signalling,
resistance
cell
death,
activation
invasion
metastasis,
reprogramming
energy
metabolism,
genome
instability,
immune
evasion.
This
suggests
they
may
be
novel
therapeutic
targets
for
treatment.
other
aberrant
expression
molecules
linked
clinicopathological
staging,
lymph
node
unfavourable
prognoses
patients
with
cancer,
indicating
their
potential
as
biomarkers.
review
consolidates
discovery,
identification,
detection
methodologies,
functional
roles
modification,
analysing
mechanisms
by
which
contribute
development,
exploring
clinical
applications
diagnostics
therapy,
thereby
providing
innovative
strategies
identification
targeted
