MedComm,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Abstract
RNA
modifications
are
emerging
as
critical
cancer
regulators
that
influence
tumorigenesis
and
progression.
Key
modifications,
such
N6‐methyladenosine
(m
6
A)
5‐methylcytosine
5
C),
implicated
in
various
cellular
processes.
These
regulated
by
proteins
write,
erase,
read
modulate
stability,
splicing,
translation,
degradation.
Recent
studies
have
highlighted
their
roles
metabolic
reprogramming,
signaling
pathways,
cell
cycle
control,
which
essential
for
tumor
proliferation
survival.
Despite
these
scientific
advances,
the
precise
mechanisms
affect
remain
inadequately
understood.
This
review
comprehensively
examines
role
play
proliferation,
metastasis,
programmed
death,
including
apoptosis,
autophagy,
ferroptosis.
It
explores
effects
on
epithelial–mesenchymal
transition
(EMT)
immune
microenvironment,
particularly
metastasis.
Furthermore,
modifications’
potential
therapies,
conventional
treatments,
immunotherapy,
targeted
is
discussed.
By
addressing
aspects,
this
aims
to
bridge
current
research
gaps
underscore
therapeutic
of
targeting
improve
treatment
strategies
patient
outcomes.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(4), P. 1238 - 1255
Published: Jan. 1, 2024
RNA
modifications
play
a
pivotal
role
in
regulating
cellular
biology
by
exerting
influence
over
distribution
features
and
molecular
functions
at
the
post-transcriptional
level.Among
these
modifications,
N7-methylguanosine
(m7G)
stands
out
as
one
of
most
prevalent.Over
recent
years,
significant
attention
has
been
directed
towards
understanding
implications
m7G
modification.This
modification
is
present
diverse
molecules,
including
transfer
RNAs,
messenger
ribosomal
other
noncoding
RNAs.Its
regulation
occurs
through
series
specific
methyltransferases
m7G-binding
proteins.Notably,
implicated
various
diseases,
prominently
across
multiple
cancer
types.Earlier
studies
have
elucidated
significance
context
immune
within
tumor
microenvironment.This
comprehensive
review
culminates
synthesis
findings
related
to
modulation
cells
infiltration,
encompassing
T
cells,
B
innate
all
orchestrated
modification.Furthermore,
interplay
between
its
regulatory
proteins
can
profoundly
affect
efficacy
adjuvant
therapeutics,
thereby
potentially
serving
biomarker
therapeutic
target
for
combinatory
interventions
types.
NAR Cancer,
Journal Year:
2024,
Volume and Issue:
6(1)
Published: Jan. 9, 2024
Abstract
Recent
advancements
have
illuminated
the
critical
role
of
RNA
modifications
in
post-transcriptional
regulation,
shaping
landscape
gene
expression.
This
review
explores
how
tRNA
emerge
as
players,
fine-tuning
functionalities
that
not
only
maintain
fidelity
protein
synthesis
but
also
dictate
expression
and
translation
profiles.
Highlighting
their
dysregulation
a
common
denominator
various
cancers,
we
systematically
investigate
intersection
both
cytosolic
mitochondrial
with
cancer
biology.
These
impact
key
processes
such
cell
proliferation,
tumorigenesis,
migration,
metastasis,
bioenergetics
modulation
tumor
immune
microenvironment.
The
recurrence
altered
modification
patterns
across
different
types
underscores
significance
development,
proposing
them
potential
biomarkers
actionable
targets
to
disrupt
tumorigenic
processes,
offering
new
avenues
for
precision
medicine
battle
against
cancer.
Gene,
Journal Year:
2024,
Volume and Issue:
905, P. 148234 - 148234
Published: Feb. 2, 2024
Ameloblastoma
(AM),
a
common
odontogenic
epithelial
tumor,
exhibits
aggressive
growth
due
to
incomplete
encapsulation
within
the
jawbone.
Postoperative
recurrence
is
significant
concern,
closely
associated
with
its
invasive
nature.
We
investigate
role
of
tRNA
N-7
methylguanosine
(m
MedComm,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Abstract
RNA
modifications
are
emerging
as
critical
cancer
regulators
that
influence
tumorigenesis
and
progression.
Key
modifications,
such
N6‐methyladenosine
(m
6
A)
5‐methylcytosine
5
C),
implicated
in
various
cellular
processes.
These
regulated
by
proteins
write,
erase,
read
modulate
stability,
splicing,
translation,
degradation.
Recent
studies
have
highlighted
their
roles
metabolic
reprogramming,
signaling
pathways,
cell
cycle
control,
which
essential
for
tumor
proliferation
survival.
Despite
these
scientific
advances,
the
precise
mechanisms
affect
remain
inadequately
understood.
This
review
comprehensively
examines
role
play
proliferation,
metastasis,
programmed
death,
including
apoptosis,
autophagy,
ferroptosis.
It
explores
effects
on
epithelial–mesenchymal
transition
(EMT)
immune
microenvironment,
particularly
metastasis.
Furthermore,
modifications’
potential
therapies,
conventional
treatments,
immunotherapy,
targeted
is
discussed.
By
addressing
aspects,
this
aims
to
bridge
current
research
gaps
underscore
therapeutic
of
targeting
improve
treatment
strategies
patient
outcomes.
