International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125101 - 125101
Опубликована: Дек. 19, 2024
Язык: Английский
Cancer Communications, Год журнала: 2024, Номер 44(2), С. 185 - 204
Опубликована: Янв. 13, 2024
Abstract Cellular metabolism is the fundamental process by which cells maintain growth and self‐renewal. It produces energy, furnishes raw materials, intermediates for biomolecule synthesis, modulates enzyme activity to sustain normal cellular functions. foundation of life processes plays a regulatory role in various biological functions, including programmed cell death. Ferroptosis recently discovered form iron‐dependent The inhibition ferroptosis crucial tumorigenesis tumor progression. However, metabolism, particularly glucose amino acid cancer not well understood. Here, we reviewed glucose, lipid, acid, iron selenium involvement elucidate impact different metabolic pathways on this process. Additionally, provided detailed overview agents used induce ferroptosis. We explained that maintaining intracellular redox homeostasis disrupting these renders them more susceptible iron‐induced death, resulting enhanced killing. combination inducers inhibitors may be novel approach future therapy an important strategy advance development treatments.
Язык: Английский
Процитировано
23
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Июль 31, 2024
Colorectal cancer (CRC) is the second most common malignant tumor worldwide, and its incidence rate increases annually. Early diagnosis treatment are crucial for improving prognosis of patients with colorectal cancer. Circular RNAs noncoding a closed-loop structure that play significant role in development. However, circular CRC poorly understood.
Язык: Английский
Процитировано
11
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529
Опубликована: Июнь 1, 2024
Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,
Язык: Английский
Процитировано
9
Heliyon, Год журнала: 2024, Номер 10(18), С. e37613 - e37613
Опубликована: Сен. 1, 2024
Oxaliplatin (OXA)-based therapy is effective in the treatment of multiple cancers. However, primary or acquired OXA resistance remains an emerging challenge for its clinical application. Ferroptosis iron-dependent mode cell death that has been demonstrated to play essential role chemoresistance many drugs, including OXA. In particular, dysregulation SLC7A11-GPX4, one major antioxidant systems ferroptosis, was found colorectal cancer (CRC) and hepatocellular carcinoma (HCC). addition, Nrf2, upstream regulator GPX4 other factors, also involved CRC HCC. Inhibition SLC7A11-GPX4 Nrf2 by genetic deletion pharmaceutical inhibition could significantly reverse resistance. Long noncoding RNA (lncRNA) participates ferroptosis cells. Specifically, LINC01134 promotes recruitment promoter GPX4, thereby exerting transcriptional regulation which eventually increases sensitivity HCC through upregulation ferroptosis. On hand, a novel lncRNA DACT3-AS1 sensitizes gastric cells miR-181a-5p/sirtuin 1(SIRT1)-mediated Therapies based on combination enhancers provide new therapeutic insights overcome present review, we current understanding ferroptosis-related resistance, highlight pathogenesis chemoresistance, summarize available therapies target enhancing
Язык: Английский
Процитировано
5
Journal of Trace Elements in Medicine and Biology, Год журнала: 2025, Номер unknown, С. 127607 - 127607
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Март 3, 2025
Aberrant lipid metabolism is a well-recognized hallmark of cancer. Notably, breast cancer (BC) arises from lipid-rich microenvironment and depends significantly on metabolic reprogramming to fulfill its developmental requirements. In this review, we revisit the pivotal role in BC, underscoring impact progression tumor microenvironment. Firstly, delineate overall landscape highlighting roles patient prognosis. Given that lipids can also act as signaling molecules, next describe exchanges between BC cells other cellular components Additionally, summarize therapeutic potential targeting aspects processes, lipid-related transcription factors immunotherapy BC. Finally, discuss possibilities problems associated with clinical applications lipid‑targeted therapy propose new research directions advances spatiotemporal multi-omics.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161350 - 161350
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 19, 2025
Cancer is one of the leading causes death worldwide. Many therapies are being used to treat this disease, however, new treatments now implemented, since they not always effective and their secondary effects represent main reasons for cancer patients’ loss life quality during progression disease. In scenario, Ocoxin a mixture plant extracts, amino acids, vitamins minerals, known its antioxidant, anti-inflammatory immunoregulatory properties, which has shown exert antitumor in many cancers. The aim study elucidate mechanism action compound colorectal cancer, triple negative breast pancreatic prostate cancer. Analyses performed through RNA sequencing revealed that effect appears be alteration cell metabolism, especially inducing process ferroptosis. Nevertheless, modulation cycle was also remarkable. altered 13 genes common all four cancers were only associated metabolism but involved integrated stress response unfolded protein response, suggesting induction several pathways. Although mechanisms vary according type highlights potential as an adjunctive treatment improve outcomes therapy.
Язык: Английский
Процитировано
0
ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 15, 2025
Endometrial cancer ranks among the most common gynecological cancers, with increasing rates of incidence and death. Cold atmospheric plasma (CAP) has become a promising novel therapeutic approach for treatment. Nevertheless, specific impact CAP on endometrial remains inadequately characterized. This study aimed to investigate effect progression reveal its regulatory mechanisms. Colony formation, EdU, wound-healing, transwell assay were used detect progression. Proteomics is employed identify potential targets signaling pathways through which impacts cells. MDA, lipid ROS, JC-1 MMP assays ferroptosis. Immunoprecipitation-mass spectrometry, co-immunoprecipitation, immunofluorescence co-localization, molecular docking analyze USP49 HDAC3 interactions. The tumor xenografts model determined that inhibits growth in vivo. observed significant inhibitory proliferation migration cells reported first time induces ferroptosis Mechanistically, activated transcription p53 by modulating mediated histone H3K18 lactylation, resulting upregulation driving cell interaction between was validated mass spectrometry co-immunoprecipitation experiments. regulation contingent upon USP49, wherein down-regulation augments ubiquitination HDAC3, consequently diminishing protein stability. Furthermore, animal models transplanted tumors corroborated Our findings illustrate suppressive treatment uncover mechanism CAP. Specifically, modulates pathway HDAC3/H3K18la/p53 axis, presenting
Язык: Английский
Процитировано
0