“Find Me” and “Eat Me” signals: tools to drive phagocytic processes for modulating antitumor immunity

Cancer Communications, Journal Year: 2024, Volume and Issue: 44(7), P. 791 - 832

Published: June 23, 2024

Phagocytosis, a vital defense mechanism, involves the recognition and elimination of foreign substances by cells. Phagocytes, such as neutrophils macrophages, rapidly respond to invaders; macrophages are especially important in later stages immune response. They detect "find me" signals locate apoptotic cells migrate toward them. Apoptotic then send "eat that recognized phagocytes via specific receptors. "Find can be strategically harnessed modulate antitumor immunity support cancer therapy. These signals, calreticulin phosphatidylserine, mediate potent pro-phagocytic effects, thereby promoting engulfment dying or their remnants neutrophils, dendritic inducing tumor cell death. This review summarizes phagocytic including concepts, signaling mechanisms, involved ligands, functions. Furthermore, we delineate relationships between molecules tumors, roles these initiation, progression, diagnosis, patient prognosis. The interplay with biology is elucidated, approaches enhance explored. Additionally, novel therapeutic strategies combine better bridge innate adaptive treatment patients discussed.

Language: Английский

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A pH and glutathione-responsive carbon monoxide-driven nano-herb delivery system for enhanced immunotherapy in colorectal cancer

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 659 - 677

Published: Oct. 28, 2024

Language: Английский

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Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

The low hydrostatic pressure in the intervertebral disc plays a crucial role maintaining homeostasis of environment, particularly supporting physiological functions nucleus pulposus cells (NPCs). However, underlying mechanisms remain poorly understood. TRPV4, baroreceptor disc, is primarily responsible for converting extracellular signals into intracellular chemical signals. Upon activation, TRPV4 facilitates influx calcium ions, thereby regulating behavior NP cells. Calreticulin (CRT), an endoplasmic reticulum retention protein, performs various functions, including regulation levels. CRT also exhibits distinct roles depending on its subcellular localization. In this study, we observed that under pressure, activation and subsequent led to increase synthesis significant rise cytosolic expression. This was followed by depolymerization focal adhesion (FA) complexes, consisting FAK integrin β1, which resulted collagen type II (Col II) decrease I I). These changes matrix (ECM) composition helped maintain function Furthermore, overexpression enhanced ability resist partial functional damage caused high pressure. Taken together, our findings suggested cell TRPV4/CRT/FA complex signaling axis.

Language: Английский

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Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119485 - 119485

Published: Feb. 1, 2025

Language: Английский

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From death to birth: how osteocyte death promotes osteoclast formation

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Bone remodeling is a dynamic and continuous process involving three components: bone formation mediated by osteoblasts, resorption osteoclasts, formation-resorption balancing regulated osteocytes. Excessive osteocyte death found in various diseases, such as postmenopausal osteoporosis (PMOP), osteoclasts are increased activated at sites. Currently, apart from apoptosis necrosis previously established, more forms of cell reported, including necroptosis, ferroptosis pyroptosis. These play important role the development inflammatory diseases diseases. Increasing studies have revealed that promote osteoclast via different mechanism, actively secreting pro-inflammatory pro-osteoclastogenic cytokines, tumor factor alpha (TNF-α) receptor activator nuclear factor-kappa B ligand (RANKL), or passively releasing damage associated molecule patterns (DAMPs), high mobility group box 1 (HMGB1). This review summarizes established potential mechanisms which regulate formation, aiming to provide better understanding disease therapeutic target.

Language: Английский

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Role of Cell Deaths in Human Disabilities

Published: Jan. 1, 2025

Language: Английский

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Evoking the Cancer-immunity cycle by targeting the tumor-specific antigens in Cancer immunotherapy

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114576 - 114576

Published: April 2, 2025

Language: Английский

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PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic Framework with Effective Nanozyme Performance and Cuproptosis Induction Efficacy for Enhanced PD-L1-based Immunotherapy

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101317 - 101317

Published: Oct. 30, 2024

Language: Английский

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