Anticancer Efficacy of Decursin: A Comprehensive Review with Mechanistic Insights DOI Creative Commons

Tanzila Akter Eity,

Md. Shimul Bhuia, Raihan Chowdhury

et al.

Future Pharmacology, Journal Year: 2025, Volume and Issue: 5(2), P. 17 - 17

Published: April 10, 2025

Introduction: Decursin is a pyranocoumarin natural phytochemical found in the Angelica gigas Nakai herb, which shows various therapeutic properties and beneficial effects against diseases. Objective: The aim of this study was to find anticancer potential decursin its molecular mechanisms involved with different effects. Methodology: All relevant data concerning compound cancer were collected using scientific search engines, including PubMed, Scopus, Springer Link, Wiley Online, Web Science, Scifinder, ScienceDirect, Google Scholar. Results: This that through mechanisms, such as apoptosis, cell cycle arrest, inhibition proliferation, autophagy, angiogenesis, cytotoxicity, invasion migration number cancers, breast, bladder, lung, colon, skin, ovarian, prostate, pancreatic, bone cancers. also discovered has ability affect several signaling pathways PI3K/AKT/mTOR, JAK/STAT, MAPK pathways. Findings revealed expresses poor oral bioavailability. Conclusions: Based on analysis from literature-based study, be considered candidate treatment cancer. However, more clinical research suggested establish proper efficacy, safety, human dosage.

Language: Английский

Anticonvulsant effect of (±) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies DOI
Raihan Chowdhury, Md. Shimul Bhuia, Md. Sakib Al Hasan

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: 175, P. 105704 - 105704

Published: Feb. 22, 2024

Language: Английский

Citations

35
Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways DOI Creative Commons
Rubel Hasan, Abdulrahman Alshammari, Norah A. Albekairi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 19, 2024

Abstract The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and silico studies. To assess effect, doses 50 mg/kg b.w. copper sulfate (CuSO 4 ⋅5H 2 O) were given orally 2-day-old chicks. test compound at two 20 40 On other hand, aprepitant (16 mg/kg), domperidone (6 diphenhydramine (10 hyoscine (21 ondansetron (5 mg/kg) administered as positive controls (PCs). vehicle used a control group. Combination therapies with referral drugs also three separate groups animals see synergistic antagonizing compound. Molecular docking visualization ligand-receptor interaction performed different computational tools against various emesis-inducing receptors (D , D 3 5HT H 1 M –M 5 ). Furthermore, pharmacokinetics toxicity properties selected ligands predicted by SwissADME Protox-II online servers. Findings indicated that AA dose-dependently enhances latency emetic retching reduces number compared Among treatments, treated (40 exhibited highest (98 ± 2.44 s) reduced (11.66 2.52 times) groups. Additionally, molecular exhibits binding affinity (− 10.2 kcal/mol) toward an elevated 8.1 kcal/mol), 7.7 8.7 8.5 than ligands. Taken together, our suggests has potent effects interacting 5TH muscarinic receptor pathways. However, additional extensive pre-clinical clinical studies are required efficacy AA.

Language: Английский

Citations

32
An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms DOI Creative Commons
Raihan Chowdhury, Md. Shimul Bhuia, Polrat Wilairatana

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32899 - e32899

Published: June 1, 2024

Natural products are being developed as possible treatment options due to the rising prevalence of cancer and harmful side effects synthetic medications. Arctiin is a naturally occurring lignan found in numerous plants exhibits different pharmacological activities, along with cancer. To elucidate anticancer properties underlying mechanisms action, comprehensive search various electronic databases was conducted using appropriate keywords identify relevant publications. The findings suggest that arctiin against tumor formation cancers such cervical, myeloma, prostate, endothelial, gastric, colon several preclinical investigations. This compound exerts its effect through cellular mechanisms, including mitochondrial dysfunction, cell cycle at phases (G2/M), inhibition proliferation, apoptotic death, cytotoxic effects, well migration invasion malignant cells. Moreover, study also revealed that, among pathways, shown be more potent terms PI3K/AKT JAK/STAT signaling pathways. However, pharmacokinetic investigation indicated compound's poor oral bioavailability. Because these findings, might considered promising chemotherapeutic drug candidate.

Language: Английский

Citations

16
Anxiolytic-like Effects by trans-Ferulic Acid Possibly Occur through GABAergic Interaction Pathways DOI Creative Commons
Md. Shimul Bhuia, Md. Rokonuzzman,

Md. Imran Hossain

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1271 - 1271

Published: Sept. 7, 2023

Numerous previous studies reported that ferulic acid exerts anxiolytic activity. However, the mechanisms have yet to be elucidated. The current study aimed investigate effect of trans-ferulic (TFA), a stereoisomer acid, and evaluated its underlying mechanism using in vivo computational studies. For this, different experimental doses TFA (25, 50, 75 mg/kg) were administered orally Swiss albino mice, various behavioral methods open field, hole board, swing box, light-dark tests carried out. Diazepam (DZP), positive allosteric modulator GABAA receptor, was employed as control at dose 2 mg/kg, distilled water served vehicle. Additionally, molecular docking performed estimate binding affinities DZP toward receptor subunits α2 α3, which are associated with effect; visualizations ligand-receptor interaction out tools. Our findings indicate dose-dependently reduces locomotor activity animals comparison controls, calming their behaviors. In addition, exerted highest affinity (-5.8 kcal/mol) subunit by forming several hydrogen hydrophobic bonds. Taken together, our suggest similar DZP, compound moderate through GABAergic pathway. We further clinical develop reliable agent.

Language: Английский

Citations

37
Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies DOI
Meher Afroz, Md. Shimul Bhuia, Md. Anisur Rahman

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 965, P. 176289 - 176289

Published: Dec. 27, 2023

Language: Английский

Citations

36
Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review DOI Creative Commons
Md. Shimul Bhuia, Polrat Wilairatana, Jannatul Ferdous

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6141 - 6141

Published: Aug. 19, 2023

Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases ailments. These food items prominent sources of phytochemicals that exhibit chemopreventive therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in Uncaria species has multitude benefits. It foodstuffs such fish, seafood, meat, poultry, dairy, some grain products among other things. In addition, it present fruits including corn, cauliflower, mushrooms, potatoes, bamboo shoots, bananas, cantaloupe, citrus fruits. The primary emphasis this study summarize the pharmacological activities underlying mechanisms HSN different diseases, well biopharmaceutical features. For this, data were collected (up date 1 July 2023) from reliable authentic literature by searching academic search engines, PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. Findings indicated exerts preclinical experimental systems. exhibits anti-inflammatory, antiviral, anti-diabetic, antioxidant with beneficial neurological cardiovascular Our findings indicate promising anticancer potentials via molecular mechanisms, apoptotic cell death, induction oxidative stress, cytotoxic effect, anti-proliferative genotoxic inhibition cancer migration invasion cancers lung, breast, antitumor human T-cell leukemia. Taken all together, show can be agent cancer.

Language: Английский

Citations

33
Therapeutic potentials of ononin with mechanistic insights: A comprehensive review DOI
Md. Shimul Bhuia, Asma Aktar, Raihan Chowdhury

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 56, P. 103302 - 103302

Published: Oct. 27, 2023

Language: Английский

Citations

24
An Insight of Plant Source, Toxicological Profile, and Pharmacological Activities of Iridoid Loganic Acid: A Comprehensive Review DOI Open Access
Asma Aktar, Md. Shimul Bhuia, Raihan Chowdhury

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract This study evaluates the pharmacological effects of iridoid glucoside loganic acid, a plant constituent with diverse properties, based on literature, and explores underlying cellular mechanisms for treating several ailments. Data were collected from reliable electronic databases, including PubMed, Scopus, Web Science, Google Scholar, etc. The results demonstrated anti‐inflammatory, anti‐oxidant, other protective acid metabolic diseases disorders such as atherosclerosis, diabetes, obesity, in addition to its osteoprotective anticancer properties. antioxidant activity demonstrates capacity protect cells oxidative damage mitigates inflammation by reducing inflammatory cytokines involving TNF‐α IL‐6, substantially upregulating expression PPAR‐γ/α, decreasing clinical signs inflammation‐related conditions related hypertriglyceridemia atherosclerosis. Meanwhile, inhibits bone loss, exhibits properties increasing mRNA levels synthesizing genes Alpl, Bglap, Sp7, significantly increases osteoblastic proliferation preosteoblast cells. Loganic is an anti‐metastatic drug that reduces MnSOD expression, EMT metastasis, prevents migration, proliferation, invasion hepatocellular carcinoma However, additional trials are required assess safety, efficacy, human dose.

Language: Английский

Citations

12
Gigantol, a promising natural drug for inflammation: a literature review and computational based study DOI
Raihan Chowdhury, Md. Shimul Bhuia, Asraful Islam Rakib

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: April 16, 2024

Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown number of biological activities, making it an attractive candidate for potential medical applications. This systematic review aims to shed light on gigantol's promising role in inflammation treatment and its underlying mechanisms. Gigantol exhibits anti-inflammatory properties pre-clinical pharmacological test systems. It effectively reduced the levels pro-inflammatory markers arachidonic acid metabolites through pathways, such as NF-κB, AKT, PI3K, JNK/cPLA2/12-LOX. The in-silico investigations demonstrated that MMP-13 enzyme served most target gigantol with highest binding affinity (docking score = −8.8 kcal/mol). Encouragingly, absorption, distribution, metabolism, excretion, toxicity (ADMET) analysis confirmed compatibility necessary physiochemical, pharmacokinetic, properties, bolstering drug candidate. well-documented could be agent treating near future.

Language: Английский

Citations

11
A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives DOI
Md. Shimul Bhuia, Raihan Chowdhury,

Mst. Asma Akter

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3877 - 3898

Published: May 20, 2024

Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.

Language: Английский

Citations

10