A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 3877 - 3898
Опубликована: Май 20, 2024
Abstract
Resveratrol
is
a
widely
recognized
polyphenolic
phytochemical
found
in
various
plants
and
their
fruits,
such
as
peanuts,
grapes,
berry
fruits.
It
renowned
for
its
several
health
advantages.
The
well
known
anticancer
properties,
substantial
amount
of
clinical
evidence
has
also
established
promise
chemotherapeutic
agent.
This
study
focuses
on
assessing
the
properties
resveratrol
gaining
insight
into
underlying
molecular
mechanisms.
evaluates
biopharmaceutical,
toxicological
characteristics,
utilization
to
determine
suitability
further
development
reliable
Therefore,
information
about
preclinical
studies
was
collected
from
different
electronic
databases
up‐to‐date
(2018–2023).
Findings
this
revealed
that
potent
therapeutic
benefits
against
cancers
involving
mechanisms,
induction
oxidative
stress,
cytotoxicity,
inhibition
cell
migration
invasion,
autophagy,
arresting
S
phase
cycle,
apoptotic,
anti‐angiogenic,
antiproliferative
effects
by
regulating
pathways
including
PI3K/AKT,
p38/MAPK/ERK,
NGFR‐AMPK‐mTOR,
so
on.
However,
compound
poor
oral
bioavailability
due
reduced
absorption;
limitation
overcome
applying
nanotechnology
(nanoformulation
resveratrol).
Clinical
application
showed
types
cancer
with
no
serious
adverse
effects.
We
suggest
additional
extensive
check
efficacy,
safety,
long‐term
hazards.
could
involve
larger
number
samples
establish
drug
treatment
cancer.
Язык: Английский
Phytochemical analysis and biological investigation of Cheilanthes tenuifolia (Burm.f.) Swartz
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 4, 2024
Introduction:
Cheilanthes
tenuifolia
is
an
evergreen
ornamental
small
fern,
belonging
to
the
family
Pteridaceae,
that
grows
in
warm
and
rocky
regions
worldwide.
Many
species
of
genus
are
evidently
endowed
with
important
phytochemicals
bioactivities.
This
study
aimed
perform
a
preliminary
phytochemical
analysis
leaves
alongside
evaluation
free
radical
scavenging,
anti-inflammatory,
antimicrobial,
clot
lysis
activities
extract
fractions.
Materials
methods:
A
was
done
after
fractionation
ethanolic
(ECT)
n
-hexane
(HCT)
chloroform
(CCT).
Then,
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
egg
albumin
RBC
membrane
stabilization
tests,
disc
diffusion,
human
blood
assays
were
performed.
Results:
Phytochemical
investigations
suggested
plant
rich
alkaloids,
glycosides,
tannins,
flavonoids.
All
obtained
fractions
exhibited
concentration-dependent
inhibition
protein
denaturation
capacities.
Except
for
antifungal
ECT
better
DPPH
antibacterial,
capacities
than
HCT
CCT
However,
all
mild
anti-inflammatory
activity.
Conclusion:
C.
might
be
good
source
antioxidant,
anti-microbial,
anti-atherothrombotic
agents.
Further
studies
required
isolate
characterize
active
principles
liable
each
bioactivity,
along
possible
molecular
interactions.
Язык: Английский
Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(7)
Опубликована: Май 17, 2024
Ferulic
acid
(FA)
is
a
naturally
occurring
phenolic
compound
commonly
found
in
the
plant
Ferula
communis.
This
study
aims
to
investigate
hepatoprotective
effect
of
FA
and
its
derivatives
(methyl
ferulic
trans-ferulic
acid)
against
oxidative
stress
inflammation-related
hepatotoxicity
due
toxicants
based
on
results
different
non-clinical
preclinical
tests.
For
this,
data
was
collected
from
reliable
electronic
databases
such
as
PubMed,
Google
Scholar,
ScienceDirect,
etc.
The
this
investigation
demonstrated
that
have
potent
effects
damage.
findings
also
revealed
these
protective
are
antioxidant
anti-inflammatory
chemical
compound.
analogues
significantly
inhibit
free
radical
generation
hinder
proinflammatory
markers
inflammatory
enzymes,
resulting
diminished
cytotoxic
apoptotic
hepatocyte
death.
compounds
prevent
intracellular
lipid
accumulation
provide
effects.
Язык: Английский
Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(7)
Опубликована: Май 16, 2024
Rosavin
is
an
alkylbenzene
diglycoside
primarily
found
in
Rhodiola
rosea
(L.),
demonstrating
various
pharmacological
properties
a
number
of
preclinical
test
systems.
This
study
focuses
on
evaluating
the
effects
rosavin
and
underlying
molecular
mechanisms
based
different
non-clinical
investigations.
The
findings
revealed
that
has
anti-microbial,
antioxidant,
protective
effects,
including
neuroprotective
against
neurodegenerative
ailments
such
as
mild
cognitive
disorders,
neuropathic
pain,
depression,
stress,
well
gastroprotective,
osteoprotective,
pulmoprotective,
hepatoprotective
activities.
effect
due
to
its
capability
diminish
inflammation
oxidative
stress.
compound
also
manifested
anticancer
cancer
via
exerting
cytotoxicity,
apoptotic
cell
death,
arresting
phases
(G
Язык: Английский
Gynura procumbens leaf extract-loaded self-microemulsifying drug delivery system offers enhanced protective effects in the hepatorenal organs of the experimental rats
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0304435 - e0304435
Опубликована: Фев. 24, 2025
Gynura
procumbens
,
known
as
longevity
spinach,
is
a
plant
traditionally
used
in
tropical
Asian
countries
for
its
anti-inflammatory,
hepatoprotective,
anti-hypertensive,
and
anti-hyperglycemic
properties.
The
current
study
aimed
to
enhance
the
hepatorenal
protective
activity
of
leaf
extract
(GLE)
by
developing
self-microemulsifying
drug
delivery
system
(SMEDDS).
SMEDDS-GLE
exhibited
formation
small
micelles
with
mean
droplet
size
231
nm.
This
resulted
significant
enhancement
dispersion
GLE
water,
evidenced
dispersibility
that
was
at
least
4.8
times
greater
than
alone.
In
rat
model
hepatic
injury
induced
cisplatin
(7.5
mg/kg,
i.p.
),
administration
(75
mg-GLE/kg,
p.o.
)
significantly
reduced
liver
damage,
observed
histological
examination
levels
plasma
biomarkers
associated
injury.
Furthermore,
according
findings
assessment,
enhanced
nephroprotective
benefits
acute
kidney
Based
on
these
findings,
strategic
application
SMEDDS-based
approach
could
be
viable
choice
GLE’s
nutraceutical
Язык: Английский
Anticancer Efficacy of Decursin: A Comprehensive Review with Mechanistic Insights
Future Pharmacology,
Год журнала:
2025,
Номер
5(2), С. 17 - 17
Опубликована: Апрель 10, 2025
Introduction:
Decursin
is
a
pyranocoumarin
natural
phytochemical
found
in
the
Angelica
gigas
Nakai
herb,
which
shows
various
therapeutic
properties
and
beneficial
effects
against
diseases.
Objective:
The
aim
of
this
study
was
to
find
anticancer
potential
decursin
its
molecular
mechanisms
involved
with
different
effects.
Methodology:
All
relevant
data
concerning
compound
cancer
were
collected
using
scientific
search
engines,
including
PubMed,
Scopus,
Springer
Link,
Wiley
Online,
Web
Science,
Scifinder,
ScienceDirect,
Google
Scholar.
Results:
This
that
through
mechanisms,
such
as
apoptosis,
cell
cycle
arrest,
inhibition
proliferation,
autophagy,
angiogenesis,
cytotoxicity,
invasion
migration
number
cancers,
breast,
bladder,
lung,
colon,
skin,
ovarian,
prostate,
pancreatic,
bone
cancers.
also
discovered
has
ability
affect
several
signaling
pathways
PI3K/AKT/mTOR,
JAK/STAT,
MAPK
pathways.
Findings
revealed
expresses
poor
oral
bioavailability.
Conclusions:
Based
on
analysis
from
literature-based
study,
be
considered
candidate
treatment
cancer.
However,
more
clinical
research
suggested
establish
proper
efficacy,
safety,
human
dosage.
Язык: Английский
Gynura procumbens Leaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 17, 2024
Abstract
Gynura
procumbens
,
known
as
longevity
spinach,
is
a
plant
traditionally
used
in
tropical
Asian
countries
for
its
anti-inflammatory,
hepatoprotective,
anti-hypertensive,
anti-hyperglycemic,
and
anti-inflammatory
properties.
The
current
study
aimed
to
enhance
the
hepatorenal
protective
activity
of
leaf
extract
(GLE)
by
developing
self-microemulsifying
drug
delivery
system
(SMEDDS).
SMEDDS-GLE
exhibited
formation
small
micelles
with
mean
droplet
size
231
nm.
This
resulted
significant
enhancement
dispersion
GLE
water,
evidenced
dispersibility
that
was
at
least
4.8
times
greater
than
alone.
In
rat
model
hepatic
injury
induced
cisplatin
(7.5
mg/kg,
i.p.
),
administration
(75
mg-GLE/kg,
p.o.
)
significantly
reduced
liver
damage,
observed
histological
examination
levels
plasma
biomarkers
associated
injury.
Furthermore,
according
findings
assessment,
enhanced
nephroprotective
benefits
acute
kidney
Based
on
these
findings,
strategic
application
SMEDDS-based
approach
could
be
viable
choice
GLE’s
nutraceutical
Язык: Английский