Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

The International Journal of Neuropsychopharmacology, Год журнала: 2008, Номер 11(06)

Опубликована: Янв. 21, 2008

Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as brain comparatively greater vulnerability to oxidative damage. This review aims examine current evidence for role its academic clinical implications. A literature search was conducted using Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, Cochrane databases, with time-frame extending September 2007. The broadest data mechanisms have derived from studies schizophrenia, where is available different areas research, including marker assays, psychopharmacology studies, trials antioxidants. For bipolar disorder depression, solid foundation hypotheses provided by biochemical, genetic, pharmacological, preclinical therapeutic one trial. pathophysiology anxiety disorders strongly supported animal models, also human biochemical data. Pilot suggested efficacy N-acetylcysteine cocaine dependence, while early accumulating autism attention deficit hyperactivity disorder. In conclusion, multi-dimensional support disorders. These not only suggest that form unifying pathways but introduce new targets development interventions.

Язык: Английский

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Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Archives of Toxicology, Год журнала: 2023, Номер 97(10), С. 2499 - 2574

Опубликована: Авг. 19, 2023

Abstract A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or “good stress” characterized by low to mild levels oxidants involved in the regulation various biochemical transformations such carboxylation, hydroxylation, peroxidation, modulation signal transduction pathways Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2–related 2 (Nrf2) other processes. Increased ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods, cigarette smoking, pollution) result a harmful condition stress (“bad stress”). Although it widely accepted, that many chronic diseases are multifactorial origin, they share common denominator. Here we review importance mechanisms through which contributes pathological states an organism. Attention focused on chemistry ROS RNS (e.g. superoxide radical, hydrogen peroxide, hydroxyl radicals, peroxyl nitric oxide, peroxynitrite), their role damage DNA, proteins, membrane lipids. Quantitative qualitative assessment biomarkers also discussed. Oxidative pathology cancer, cardiovascular diseases, diabetes, neurological disorders (Alzheimer’s Parkinson’s Down syndrome), psychiatric (depression, schizophrenia, bipolar disorder), renal disease, lung disease (chronic pulmonary obstruction, cancer), aging. The concerted action antioxidants ameliorate effect achieved antioxidant enzymes (Superoxide dismutases-SODs, catalase, glutathione peroxidase-GPx), small molecular weight (vitamins C E, flavonoids, carotenoids, melatonin, ergothioneine, others). Perhaps one most effective vitamin first line defense against peroxidation promising approach appears be use flavonoids), showing weak prooxidant properties may boost cellular systems thus act preventive anticancer agents. Redox metal-based enzyme mimetic compounds potential pharmaceutical interventions sirtuins therapeutic targets for age-related anti-aging strategies

Язык: Английский

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Telomere length assessment: Biomarker of chronic oxidative stress?

Free Radical Biology and Medicine, Год журнала: 2007, Номер 44(3), С. 235 - 246

Опубликована: Окт. 11, 2007

Язык: Английский

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Oxidative stress markers in bipolar disorder: A meta-analysis

Journal of Affective Disorders, Год журнала: 2008, Номер 111(2-3), С. 135 - 144

Опубликована: Июнь 10, 2008

Язык: Английский

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Vitamin C in Disease Prevention and Cure: An Overview

Indian Journal of Clinical Biochemistry, Год журнала: 2013, Номер 28(4), С. 314 - 328

Опубликована: Авг. 31, 2013

Язык: Английский

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N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

Biological Psychiatry, Год журнала: 2008, Номер 64(6), С. 468 - 475

Опубликована: Июнь 6, 2008

Язык: Английский

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Allostatic load in bipolar disorder: Implications for pathophysiology and treatment

Neuroscience & Biobehavioral Reviews, Год журнала: 2007, Номер 32(4), С. 675 - 692

Опубликована: Дек. 5, 2007

Язык: Английский

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Oxidative stress in schizophrenia: An integrated approach

Neuroscience & Biobehavioral Reviews, Год журнала: 2010, Номер 35(3), С. 878 - 893

Опубликована: Окт. 26, 2010

Язык: Английский

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Meta-Analysis of Oxidative Stress in Schizophrenia

Biological Psychiatry, Год журнала: 2013, Номер 74(6), С. 400 - 409

Опубликована: Май 15, 2013

Язык: Английский

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Mitochondrial Complex I Activity and Oxidative Damage to Mitochondrial Proteins in the Prefrontal Cortex of Patients With Bipolar Disorder

Archives of General Psychiatry, Год журнала: 2010, Номер 67(4), С. 360 - 360

Опубликована: Апрель 1, 2010

Accumulating evidence suggests that mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of bipolar disorder schizophrenia. It remains unclear whether dysfunction, specifically complex I impairment, is associated with increased damage and, if so, this relationship specific disorder.To evaluate decreased levels electron transport chain subunit NDUFS7 are activity proteins in prefrontal cortex patients disorder, schizophrenia, or major depressive disorder.Postmortem from controls were assessed using immunoblotting, spectrophotometric, competitive enzyme immunoassay identify group differences expression I, mitochondria.University British Columbia, Vancouver, Canada. Patients Forty-five a psychiatric (15 each disorder) 15 nonpsychiatric control subjects studied.Oxidative activity.Levels significantly but unchanged those depression schizophrenia compared controls. Protein oxidation, as measured by protein carbonylation, was not depressed schizophrenic groups We observed 3-nitrotyrosine groups.Impairment may be oxidation nitration disorder. Therefore, potential therapeutic targets for

Язык: Английский

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