Cell Reports Physical Science,
Год журнала:
2024,
Номер
5(8), С. 102132 - 102132
Опубликована: Авг. 1, 2024
Alkynes
are
key
motifs
in
chemistry,
serving
as
precursors
many
organic
reactions
toward
the
synthesis
of
bioactive
compounds,
polymers,
and
new
materials.
Methods
to
synthesize
terminal
alkynes
with
an
extension
carbon
skeleton
involve
harsh
and/or
dangerous
reagents.
Further
derivatization
diaryl
largely
relies
on
popular
Sonogashira
coupling.
This
cross-coupling
uses
expensive
Pd
catalysts,
phosphine
ligands,
toxic
Cu
co-catalysts.
Herein,
we
report
a
one-pot
approach
under
transition-metal-free
conditions
from
feedstock
chemicals
(toluenes
methyl
benzoates).
is
also
applicable
preparation
conjugated
1,3-enynes
single
flask.
The
disclosed
methods
expected
be
complementary
state-of-the-art
by
streamlining
alkynes,
reducing
costs
production
these
valuable
building
blocks,
increasing
sustainability
alkynes.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(13), С. 1509 - 1514
Опубликована: Март 7, 2024
Comprehensive
Summary
The
first
total
synthesis
of
talaroconvolutin
A
(1.1
g
obtained)
and
talarofuranone
has
been
achieved
using
accessible
materials
(12
steps,
7.5%
8.2%
yields,
respectively).
Convergent
routes
involved
intramolecular
Diels−Alder
reactions
in
two
approaches
for
creating
the
decalin
moiety.
Additionally,
an
unprecedented
DMP‐mediated
domino
reaction
resulted
deoxy‐tetramic
acid
system.
These
syntheses
not
only
establish
absolute
configuration
but
also
enable
further
collaborative
studies
this
type
ferroptosis
inducers.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(7), С. 5010 - 5018
Опубликована: Март 27, 2024
Recent
years
have
seen
novel
modalities
emerge
for
the
treatment
of
human
diseases
resulting
in
an
increase
beyond
rule
5
(bRo5)
chemical
matter.
As
a
result,
synthetic
innovations
aiming
to
enable
rapid
access
complex
bRo5
molecular
entities
become
increasingly
valuable
medicinal
chemists'
toolkits.
Herein,
we
report
general
synthesis
new
class
noncanonical
amino
acids
(ncAA)
with
cyclopropyl
backbone
achieve
conformational
constraint
and
bearing
C(sp3)-rich
benzene
bioisosteres.
We
also
demonstrate
preliminary
studies
toward
utilities
these
ncAA
as
building
blocks
chemistry
research.
Cell Reports Physical Science,
Год журнала:
2024,
Номер
5(8), С. 102132 - 102132
Опубликована: Авг. 1, 2024
Alkynes
are
key
motifs
in
chemistry,
serving
as
precursors
many
organic
reactions
toward
the
synthesis
of
bioactive
compounds,
polymers,
and
new
materials.
Methods
to
synthesize
terminal
alkynes
with
an
extension
carbon
skeleton
involve
harsh
and/or
dangerous
reagents.
Further
derivatization
diaryl
largely
relies
on
popular
Sonogashira
coupling.
This
cross-coupling
uses
expensive
Pd
catalysts,
phosphine
ligands,
toxic
Cu
co-catalysts.
Herein,
we
report
a
one-pot
approach
under
transition-metal-free
conditions
from
feedstock
chemicals
(toluenes
methyl
benzoates).
is
also
applicable
preparation
conjugated
1,3-enynes
single
flask.
The
disclosed
methods
expected
be
complementary
state-of-the-art
by
streamlining
alkynes,
reducing
costs
production
these
valuable
building
blocks,
increasing
sustainability
alkynes.
