Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(3), С. 997 - 997
Опубликована: Янв. 1, 2024
Язык: Английский
Science China Chemistry, Год журнала: 2023, Номер 67(2), С. 450 - 470
Опубликована: Ноя. 3, 2023
Язык: Английский
Процитировано
50
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(16), С. 1913 - 1928
Опубликована: Апрель 24, 2024
Comprehensive Summary Organic fluorine compounds are ubiquitous and pivotally important organic molecules, yet their activation transformation have long been a formidable challenge due to the high energy low reactivity of C—F bonds. electrosynthesis, an environmentally benign synthetic method in chemistry, enables myriad chemical transformations without need for external redox reagents. In recent years, electrochemistry has emerged as powerful tool achieving bonds fluorine‐containing compounds. This review aims succinctly recapitulate latest advancements electrochemical defluorinative delve into reaction design, mechanistic insights, developmental prospects these methods. Key Scientists 1959, Lund was first pioneer electroreduction CF 3 CH group. Electrochemistry lately provided new opportunities efficient conversion fluorides. 2020, Zhou coworkers discovered carboxylation α‐CF alkenes. Lambert colleagues reported electrophotocatalytic amination aryl Electrochemical hydrodefluorination trifluoromethylketones developed by Lennox 2021. same year, Wang Guo disclosed radical alkylation alkenes with Katritzky salts alkyl precursors. Subsequently, Wu Liao described transition‐metal‐free, site‐selective arylation polyfluoroarenes (het)arenes using paired electrophotocatalysis. 2023, numerous efforts were made achieve bond activation. Xia organoboron‐controlled chemoselective sequential (deutero)hydrodefluorination trifluoroacetamides.
Язык: Английский
Процитировано
26
Organic Letters, Год журнала: 2023, Номер 26(1), С. 411 - 415
Опубликована: Дек. 26, 2023
We report a strategic exploitation of trifluoromethyl thianthrenium triflate (TT-CF3+OTf–) as both electromediator and CF3 radical precursors for paired electrolysis. Enabled by this strategy, the three-component trifluoromethylheteroaromatization alkenes alkynes was realized. The superiority TT-CF3+OTf– to other electrophilic reagents is attributed cathodic generation thianthrene (TT) mediator, which shifts heterogeneous oxidation interest homogeneous one.
Язык: Английский
Процитировано
26
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(15), С. 1679 - 1685
Опубликована: Март 15, 2024
Comprehensive Summary A novel and eco‐friendly electrochemical activation of trifluoromethyl thianthrenium triflate (TT–CF 3 + OTf − ) for trifluoromethylation imidazole‐fused heteroaromatic compounds was established. This method involves the direct electrolysis TT–CF without requirement external oxidants or catalysts, aligning with principles green chemistry. wide range including imidazo[1,2‐ a ]pyridines benzo[ d ]imidazo[2,1‐ b ]thiazoles have been successfully trifluoromethylated using this technique, exhibiting excellent compatibility various functional groups broad substrate scope. Moreover, method's applicability one‐pot sequential reactions enables reduction waste resource consumption by eliminating need intermediate purification steps.
Язык: Английский
Процитировано
10
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(10), С. 2352 - 2362
Опубликована: Апрель 5, 2024
Abstract While the emergence of electrophotochemistry provides opportunities, such a chemistry at this stage suffers from limited reaction types and high photocatalyst loadings. A self‐catalyzed electrophotosynthesis as well one with low loading is presented. These external‐oxidant‐free cyclizations are enabling applicable to range activated alkenes, affording diverse array thiocyanato heterocycles including 4‐pyrrolin‐2‐ones, isoquinoline‐1,3‐diones, indolo[2,1‐ ]isoquinolin‐6(5 H )‐ones, benzoimidazo[2,1‐ )‐ones indolin‐2‐ones, protocols amenable late‐stage diversification complex molecular architectures gram‐scale syntheses. Sunlight could serve light source, be conducted in an all‐solar‐driven mode using commercially available photovoltaic panel produce electricity.
Язык: Английский
Процитировано
9
Chinese Chemical Letters, Год журнала: 2024, Номер 35(12), С. 110104 - 110104
Опубликована: Июнь 8, 2024
Язык: Английский
Процитировано
9
Chemical Communications, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
In this study, a straightforward and environmentally benign electrochemical mono-functionalization of alkenes has been established for the synthesis alkenyl selenium sulfonates using elemental as source.
Язык: Английский
Процитировано
1
Green Chemistry, Год журнала: 2023, Номер 25(12), С. 4656 - 4661
Опубликована: Янв. 1, 2023
An electrochemical-enabled three-component cascaded cyclization of enaminones with potassium thiocyanate and alcohols to access 2-alkoxythiazoles has been developed under external oxidant-free conditions.
Язык: Английский
Процитировано
20
Current Opinion in Electrochemistry, Год журнала: 2023, Номер 43, С. 101425 - 101425
Опубликована: Ноя. 20, 2023
Язык: Английский
Процитировано
16
Advanced Synthesis & Catalysis, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Abstract The electrochemical catalyst‐free generation of carbon radicals bearing three electron‐withdrawing groups from the corresponding C−H nucleophiles remains unexplored. To this end, we report a direct electro‐oxidation strategy to access these electrophilic under conditions. Enabled by strategy, radical 1,2‐alkylarylations allylic alcohols was realized, affording β ‐quaternary ketones with high functional group compatibility. This protocol is operationally simple and also easy scale up.
Язык: Английский
Процитировано
0