Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Biomaterials Science, Год журнала: 2024, Номер 12(7), С. 1643 - 1661

Опубликована: Янв. 1, 2024

Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.

Язык: Английский

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Biomimetic Hydrogel Containing Copper Sulfide Nanoparticles and Deferoxamine for Photothermal Therapy of Infected Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(8)

Опубликована: Дек. 8, 2023

Abstract Inducing cell migration from the edges to center of a wound, promoting angiogenesis, and controlling bacterial infection are very important for diabetic wound healing. Incorporating growth factors antibiotics into hydrogels dressing is considered potential strategy meet these requirements. However, some present drawbacks greatly slow down their development toward application, such as short half‐life high price factors, low antibiotic efficiency against drug‐resistant bacteria, insufficient ability promote migration, etc. Deferoxamine (DFO) can upregulate expression HIF‐1α, thus stimulating secretion angiogenesis‐related endogenous factors. Copper sulfide (CuS) nanoparticles possess excellent antibacterial performance combined with photothermal therapy (PTT). Herein, DFO CuS incorporated biomimetic hydrogel, which mimics structure function extracellular matrix (ECM), abbreviated DFO/CuS‐ECMgel. This hydrogel expected be able adhesion degraded by cell‐secreted metalloproteinases (MMPs), then release at site exert therapeutic effects. As result, three crucial requirements healing, “beneficial effectively killing bacteria,” achieved simultaneously.

Язык: Английский

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Uni-directional release of ibuprofen from an asymmetric fibrous membrane enables effective peritendinous anti-adhesion

Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 251 - 264

Опубликована: Июнь 24, 2024

Язык: Английский

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Advanced Biomaterials Derived from Functional Polyphosphoesters: Synthesis, Properties, and Biomedical Applications

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Polyphosphoesters (PPEs) represent an innovative class of biodegradable polymers, with the phosphate ester serving as core repeating unit their polymeric backbone. Recently, biomaterials derived from functionalized PPEs have garnered significant interest in biomedical applications because commendable biocompatibility, biodegradability, and capacity for functional modification. This review commences a brief overview synthesis methodologies distinctive properties PPEs, including thermoresponsiveness, degradability, stealth effect, biocompatibility. Subsequently, delves into latest PPEs-based nanocarriers drug or gene delivery prodrugs scaffolds field, presenting several illustrative examples each application. By encapsulating advancements recent years, this aims to offer enhanced understanding serve reference PPEs.

Язык: Английский

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A Portable, Sprayable, Highly Malleable, Elastic, and Hydrophobic Antibacterial Fibrous Wound Dressing for Infected Wound Healing

Advanced Fiber Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Язык: Английский

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A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application

European Polymer Journal, Год журнала: 2023, Номер 198, С. 112388 - 112388

Опубликована: Авг. 28, 2023

Язык: Английский

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Band Gap and Reorganization Energy Prediction of Conducting Polymers by the Integration of Machine Learning and Density Functional Theory

Journal of Chemical Information and Modeling, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

The performance and reliability of machine learning (ML)-quantitative structure-property relationship (QSPR) models depend on the quality, size, diversity data set used for model training. In this study, we manually curated a large-scale containing 3120 donor-acceptor (D-A) conjugated polymers (CPs) by selecting most utilized 60 donors 52 acceptors. This serves as valuable resource ML-based prediction key electronic properties such band gap energy (Eg) hole reorganization (λh), calculated using density functional theory (DFT) to advance organic photovoltaics (OPV). Beyond construction, systematically investigated how different descriptor fingerprint types impact ML model. Recognizing that not all features contributed equally performance, conducted an in-depth analysis identify informative descriptors fundamental optoelectronic properties. Our findings show kernel partial least-squares (KPLS) regression utilizing radial molprint2D fingerprints achieved highest accuracy in predicting Eg, with R2 values 0.899 0.897, respectively. For λh prediction, integrating frontier orbital levels significantly improved achieving value 0.830. study provides comprehensive investigation influence OPV research. By analyzing why certain succeed while others fail, our offer insight into feature selection optimization accurate target property electronics. developed provide predictive framework high-performance materials design, reducing reliance labor-intensive experimental procedures computationally expensive first-principle calculations.

Язык: Английский

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Dual-Triggered Peptide-Based Polymeric Micelles Enhance Doxorubicin Delivery for Targeted Cancer Therapy

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(12), С. 14380 - 14391

Опубликована: Июнь 11, 2024

Malignant tumors present a grave risk to human health and remain major cause of death. Chemotherapy is currently the most prevalent widely used method for cancer treatment; doxorubicin (DOX), in particular, has gained substantial attention extensively researched employed as primary chemotherapy medication various types cancers. However, utilization DOX connected with significant adverse reactions, including cardiotoxicity myelosuppression, which restrict its effectiveness antitumor treatment. To tackle these challenges, drug delivery systems (DDS) have been developed, among polymeric micelles emerged promising option. In this study, we designed created dual-responsive mechanism that effectively targets extracellular intracellular enzymes tumor; objective approach augment therapeutic efficacy while simultaneously mitigating potential side effects. The were characterized stability, morphological distribution, cytotoxicity, cellular uptake, efficacy, providing valuable insights into their immense smart effective system therapy.

Язык: Английский

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Additive-Free Construction of Tetrahydropyrimidine Skeleton by using 1,3,5-Triazinane as Four-Atom Synthon

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(13), С. 9496 - 9501

Опубликована: Июнь 18, 2024

Herein, an unprecedented [4 + 2] cycloaddition of enaminone with 1,3,5-triazinane has been developed. The representative semihydrogenated aromatic heterocycle 1,2,3,4-tetrahydropyrimidines have synthesized a broad substrate scope, demonstrating potential antitumor activity. This approach smoothly conducted under additive-free and environmentally friendly conditions that are compatible various functional groups. Furthermore, the condition optimization process reveals tetrahydropyrimidine product is regulated via reaction temperature.

Язык: Английский

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Pluronic F127‐Complexed PEGylated Poly(glutamic acid)‐Cisplatin Nanomedicine for Enhanced Glioblastoma Therapy

Macromolecular Rapid Communications, Год журнала: 2024, Номер 45(21)

Опубликована: Сен. 12, 2024

Abstract Glioblastoma is one of the most aggressive and treatment‐resistant forms primary brain cancer, posing significant challenges in effective therapy. This study aimed to enhance effectiveness glioblastoma therapy by developing a unique nanomedicine composed Pluronic F127‐complexed PEGylated poly(glutamic acid)‐cisplatin (PLG‐PEG/PF127‐CDDP). PLG‐PEG/PF127‐CDDP demonstrated an optimal size 133.97 ± 12.60 nm, facilitating efficient cell uptake GL261 glioma cells. In vitro studies showed cytotoxicity against cells with half‐maximal (50%) inhibitory concentration (IC50) 12.61 µg mL −1 at 48 h 72.53% 1.89% reduction invasion. Furthermore, prolonged circulation half‐life cisplatin 9.75 vivo, leading more than 50% tumor on day 16 post‐treatment initiation murine model glioma. The treatment significantly elevated lactate levels cells, indicating enhanced metabolic disruption. Therefore, offers promising approach for due its effects improving drug delivery efficiency, therapeutic outcomes, safety while minimizing systemic side effects. work underscores potential polymer‐based nanomedicines overcoming treating tumors, paving way future clinical applications.

Язык: Английский

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