Chinese Journal of Chemistry,
Год журнала:
2023,
Номер
41(24), С. 3669 - 3676
Опубликована: Авг. 21, 2023
Comprehensive
Summary
Inflammation
is
associated
with
different
stages
of
liver
disease,
including
acute
injury,
fibrosis,
cirrhosis,
and
hepatoma.
During
the
progression
inflammation,
activation
hepatic
stellate
cells
(HSCs)
extracellular
matrix
(ECM)
deposition
are
critical
pathologies,
thus
combined
therapy
using
HSCs
ECM
as
targets
represents
a
promising
strategy
in
treatment
injury.
Here,
novel
CXCR4‐inhibiting
nanomedicine
that
can
simultaneously
deliver
AMD3100
(CXCR4
antagonist)
siPAI‐1
(siRNA
plasminogen
activator
inhibitor‐1)
was
designed
developed
to
reverse
fibrosis
by
inhibiting
degrading
deposition.
With
this
goal
mind,
Zn(II)
coordinated
polymeric
named
PAMD/Zn
polymer
siRNA
delivery
CXCR4
antagonism
capabilities
synthesized.
Overall,
our
results
suggest
recruits
pro‐inflammatory
for
fibrogenesis
inhibits
fibrolysis
at
various
Its
use
conjunction
PAI‐1
silencing
achieved
satisfactory
therapeutic
efficacy
injury
fibrosis.
The
derivative
versatile
platform
offers
valuable
benefits
diseases.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(8)
Опубликована: Дек. 8, 2023
Abstract
Inducing
cell
migration
from
the
edges
to
center
of
a
wound,
promoting
angiogenesis,
and
controlling
bacterial
infection
are
very
important
for
diabetic
wound
healing.
Incorporating
growth
factors
antibiotics
into
hydrogels
dressing
is
considered
potential
strategy
meet
these
requirements.
However,
some
present
drawbacks
greatly
slow
down
their
development
toward
application,
such
as
short
half‐life
high
price
factors,
low
antibiotic
efficiency
against
drug‐resistant
bacteria,
insufficient
ability
promote
migration,
etc.
Deferoxamine
(DFO)
can
upregulate
expression
HIF‐1α,
thus
stimulating
secretion
angiogenesis‐related
endogenous
factors.
Copper
sulfide
(CuS)
nanoparticles
possess
excellent
antibacterial
performance
combined
with
photothermal
therapy
(PTT).
Herein,
DFO
CuS
incorporated
biomimetic
hydrogel,
which
mimics
structure
function
extracellular
matrix
(ECM),
abbreviated
DFO/CuS‐ECMgel.
This
hydrogel
expected
be
able
adhesion
degraded
by
cell‐secreted
metalloproteinases
(MMPs),
then
release
at
site
exert
therapeutic
effects.
As
result,
three
crucial
requirements
healing,
“beneficial
effectively
killing
bacteria,”
achieved
simultaneously.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 23, 2024
Polyphosphoesters
(PPEs)
represent
an
innovative
class
of
biodegradable
polymers,
with
the
phosphate
ester
serving
as
core
repeating
unit
their
polymeric
backbone.
Recently,
biomaterials
derived
from
functionalized
PPEs
have
garnered
significant
interest
in
biomedical
applications
because
commendable
biocompatibility,
biodegradability,
and
capacity
for
functional
modification.
This
review
commences
a
brief
overview
synthesis
methodologies
distinctive
properties
PPEs,
including
thermoresponsiveness,
degradability,
stealth
effect,
biocompatibility.
Subsequently,
delves
into
latest
PPEs-based
nanocarriers
drug
or
gene
delivery
prodrugs
scaffolds
field,
presenting
several
illustrative
examples
each
application.
By
encapsulating
advancements
recent
years,
this
aims
to
offer
enhanced
understanding
serve
reference
PPEs.
Journal of Chemical Information and Modeling,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
The
performance
and
reliability
of
machine
learning
(ML)-quantitative
structure-property
relationship
(QSPR)
models
depend
on
the
quality,
size,
diversity
data
set
used
for
model
training.
In
this
study,
we
manually
curated
a
large-scale
containing
3120
donor-acceptor
(D-A)
conjugated
polymers
(CPs)
by
selecting
most
utilized
60
donors
52
acceptors.
This
serves
as
valuable
resource
ML-based
prediction
key
electronic
properties
such
band
gap
energy
(Eg)
hole
reorganization
(λh),
calculated
using
density
functional
theory
(DFT)
to
advance
organic
photovoltaics
(OPV).
Beyond
construction,
systematically
investigated
how
different
descriptor
fingerprint
types
impact
ML
model.
Recognizing
that
not
all
features
contributed
equally
performance,
conducted
an
in-depth
analysis
identify
informative
descriptors
fundamental
optoelectronic
properties.
Our
findings
show
kernel
partial
least-squares
(KPLS)
regression
utilizing
radial
molprint2D
fingerprints
achieved
highest
accuracy
in
predicting
Eg,
with
R2
values
0.899
0.897,
respectively.
For
λh
prediction,
integrating
frontier
orbital
levels
significantly
improved
achieving
value
0.830.
study
provides
comprehensive
investigation
influence
OPV
research.
By
analyzing
why
certain
succeed
while
others
fail,
our
offer
insight
into
feature
selection
optimization
accurate
target
property
electronics.
developed
provide
predictive
framework
high-performance
materials
design,
reducing
reliance
labor-intensive
experimental
procedures
computationally
expensive
first-principle
calculations.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(12), С. 14380 - 14391
Опубликована: Июнь 11, 2024
Malignant
tumors
present
a
grave
risk
to
human
health
and
remain
major
cause
of
death.
Chemotherapy
is
currently
the
most
prevalent
widely
used
method
for
cancer
treatment;
doxorubicin
(DOX),
in
particular,
has
gained
substantial
attention
extensively
researched
employed
as
primary
chemotherapy
medication
various
types
cancers.
However,
utilization
DOX
connected
with
significant
adverse
reactions,
including
cardiotoxicity
myelosuppression,
which
restrict
its
effectiveness
antitumor
treatment.
To
tackle
these
challenges,
drug
delivery
systems
(DDS)
have
been
developed,
among
polymeric
micelles
emerged
promising
option.
In
this
study,
we
designed
created
dual-responsive
mechanism
that
effectively
targets
extracellular
intracellular
enzymes
tumor;
objective
approach
augment
therapeutic
efficacy
while
simultaneously
mitigating
potential
side
effects.
The
were
characterized
stability,
morphological
distribution,
cytotoxicity,
cellular
uptake,
efficacy,
providing
valuable
insights
into
their
immense
smart
effective
system
therapy.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(13), С. 9496 - 9501
Опубликована: Июнь 18, 2024
Herein,
an
unprecedented
[4
+
2]
cycloaddition
of
enaminone
with
1,3,5-triazinane
has
been
developed.
The
representative
semihydrogenated
aromatic
heterocycle
1,2,3,4-tetrahydropyrimidines
have
synthesized
a
broad
substrate
scope,
demonstrating
potential
antitumor
activity.
This
approach
smoothly
conducted
under
additive-free
and
environmentally
friendly
conditions
that
are
compatible
various
functional
groups.
Furthermore,
the
condition
optimization
process
reveals
tetrahydropyrimidine
product
is
regulated
via
reaction
temperature.
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(21)
Опубликована: Сен. 12, 2024
Abstract
Glioblastoma
is
one
of
the
most
aggressive
and
treatment‐resistant
forms
primary
brain
cancer,
posing
significant
challenges
in
effective
therapy.
This
study
aimed
to
enhance
effectiveness
glioblastoma
therapy
by
developing
a
unique
nanomedicine
composed
Pluronic
F127‐complexed
PEGylated
poly(glutamic
acid)‐cisplatin
(PLG‐PEG/PF127‐CDDP).
PLG‐PEG/PF127‐CDDP
demonstrated
an
optimal
size
133.97
±
12.60
nm,
facilitating
efficient
cell
uptake
GL261
glioma
cells.
In
vitro
studies
showed
cytotoxicity
against
cells
with
half‐maximal
(50%)
inhibitory
concentration
(IC50)
12.61
µg
mL
−1
at
48
h
72.53%
1.89%
reduction
invasion.
Furthermore,
prolonged
circulation
half‐life
cisplatin
9.75
vivo,
leading
more
than
50%
tumor
on
day
16
post‐treatment
initiation
murine
model
glioma.
The
treatment
significantly
elevated
lactate
levels
cells,
indicating
enhanced
metabolic
disruption.
Therefore,
offers
promising
approach
for
due
its
effects
improving
drug
delivery
efficiency,
therapeutic
outcomes,
safety
while
minimizing
systemic
side
effects.
work
underscores
potential
polymer‐based
nanomedicines
overcoming
treating
tumors,
paving
way
future
clinical
applications.