Pd‐Catalyzed Synthesis of Aryl Esters Involving Difluorocarbene Transfer Carbonylation

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(10)

Опубликована: Фев. 14, 2024

Abstract A Pd‐catalyzed three‐component intermolecular reaction between aryl halides, ClCF 2 COONa and phenols is developed. series of benzoates were synthesized in up to 84 % yield via difluorocarbene transfer carbonylation. It devoted acquiring the targeted products by construction new C−C, C=O C−O bonds a one‐pot, one‐step process. The feature this method includes use readily available starting materials, showing outstanding resistance spatial obstruction simple operation procedure with mild conditions. Therefore, makes methodology useful alternative other schemes typically used for synthesis esters.

Язык: Английский

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eFluorination for the Rapid Synthesis of Carbamoyl Fluorides from Oxamic Acids

Organic Letters, Год журнала: 2024, Номер 26(29), С. 6103 - 6108

Опубликована: Июль 17, 2024

In this letter, we disclose the anodic oxidation of oxamic acids in presence Et3N·3HF as a practical, scalable, and robust method to rapidly access carbamoyl fluorides from readily available stable precursors. The simplicity also led us develop first flow electrochemical preparation fluorides, demonstrating scale-up feasibility proof concept.

Язык: Английский

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Catalytic Synthesis of Carbonyl Compounds Using Acyl Fluorides, Carbamoyl Fluorides, and Fluoroformates: An Overview

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(5)

Опубликована: Фев. 1, 2024

Abstract Acyl fluorides, carbamoyl fluorides and fluoroformates have been employed as efficient reagents in a number of organic syntheses. Their application catalytic transformations, however, began to be explored the early 2000s. Recently, these increasingly gained attention owing their unique reactivity diverse systems. This review aims overview advancements development processes, including transition‐metal catalysis, organocatalysis, cooperative NHC/photoredox where organofluorine compounds are acyl, carbamoyl, ester group donors.

Язык: Английский

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Synthesis of N-substituted phthalimides via Pd-catalyzed [4+1] cycloaddition reaction

Chemical Communications, Год журнала: 2023, Номер 59(100), С. 14839 - 14842

Опубликована: Янв. 1, 2023

An effective approach of Pd-catalyzed [4+1] cycloaddition 2-iodo- N -phenylbenzamides with difluorocarbene to access -substituted phthalimides is developed.

Язык: Английский

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C–F bond functionalizations via fluorinated carbenes

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(22), С. 5782 - 5804

Опубликована: Янв. 1, 2023

This feature article summarizes the developments in fluorinated carbene transformations, and their consequent C–F functionalization a cascade platform.

Язык: Английский

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Synthesis of hybrid compounds containing tetraoxane and triazole or imidazole moieties and their fungicidal activity

Russian Chemical Bulletin, Год журнала: 2024, Номер 73(5), С. 1312 - 1320

Опубликована: Май 1, 2024

Язык: Английский

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Oxidation by N–O Reagents

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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