Pd‐Catalyzed Synthesis of Aryl Esters Involving Difluorocarbene Transfer Carbonylation

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(10)

Published: Feb. 14, 2024

Abstract A Pd‐catalyzed three‐component intermolecular reaction between aryl halides, ClCF 2 COONa and phenols is developed. series of benzoates were synthesized in up to 84 % yield via difluorocarbene transfer carbonylation. It devoted acquiring the targeted products by construction new C−C, C=O C−O bonds a one‐pot, one‐step process. The feature this method includes use readily available starting materials, showing outstanding resistance spatial obstruction simple operation procedure with mild conditions. Therefore, makes methodology useful alternative other schemes typically used for synthesis esters.

Language: Английский

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eFluorination for the Rapid Synthesis of Carbamoyl Fluorides from Oxamic Acids

Organic Letters, Journal Year: 2024, Volume and Issue: 26(29), P. 6103 - 6108

Published: July 17, 2024

In this letter, we disclose the anodic oxidation of oxamic acids in presence Et3N·3HF as a practical, scalable, and robust method to rapidly access carbamoyl fluorides from readily available stable precursors. The simplicity also led us develop first flow electrochemical preparation fluorides, demonstrating scale-up feasibility proof concept.

Language: Английский

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Catalytic Synthesis of Carbonyl Compounds Using Acyl Fluorides, Carbamoyl Fluorides, and Fluoroformates: An Overview

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(5)

Published: Feb. 1, 2024

Abstract Acyl fluorides, carbamoyl fluorides and fluoroformates have been employed as efficient reagents in a number of organic syntheses. Their application catalytic transformations, however, began to be explored the early 2000s. Recently, these increasingly gained attention owing their unique reactivity diverse systems. This review aims overview advancements development processes, including transition‐metal catalysis, organocatalysis, cooperative NHC/photoredox where organofluorine compounds are acyl, carbamoyl, ester group donors.

Language: Английский

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Synthesis of N-substituted phthalimides via Pd-catalyzed [4+1] cycloaddition reaction

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(100), P. 14839 - 14842

Published: Jan. 1, 2023

An effective approach of Pd-catalyzed [4+1] cycloaddition 2-iodo- N -phenylbenzamides with difluorocarbene to access -substituted phthalimides is developed.

Language: Английский

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C–F bond functionalizations via fluorinated carbenes

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(22), P. 5782 - 5804

Published: Jan. 1, 2023

This feature article summarizes the developments in fluorinated carbene transformations, and their consequent C–F functionalization a cascade platform.

Language: Английский

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Synthesis of hybrid compounds containing tetraoxane and triazole or imidazole moieties and their fungicidal activity

Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(5), P. 1312 - 1320

Published: May 1, 2024

Language: Английский

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Oxidation by N–O Reagents

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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