Oxygen Migration–Defluorination Strategy Enables the Aminocarbonylation of Enaminones with o-Aminobenzamides and CF2Br2
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
The
development
of
different
concept
approaches
and
user-friendly
carbonyl
surrogates
for
aminocarbonylation
is
highly
desirable.
Herein,
we
report
the
photocatalytic
enaminones
with
easily
available
o-aminobenzamides
CF2Br2
through
an
oxygen
migration-defluorination
strategy.
reaction
features
switchable
transformation
construction
carbamoyl-substituted
enol
products
allows
expedient
synthesis
fully
substituted
maleimides
under
mild
conditions.
Язык: Английский
Transition metal-free thiophene construction in pure water by multiplied C-H functionalization with enaminones and elemental sulfur
Green Synthesis and Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Tandem site-selective bromination and highly regioselective Heck reaction of N-allyl enaminones: chemodivergent synthesis of polysubstituted pyrroles and pyridines
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(19), С. 5532 - 5537
Опубликована: Янв. 1, 2024
Chemodivergent
synthesis
of
polysubstituted
pyrroles
and
pyridines
from
N
-allyl
enaminones
via
tandem
site-selective
bromination
the
highly
regioselective
Heck
reaction.
Язык: Английский
Recent trends for chemoselectivity modulation in one-pot organic transformations
Hiren R. Chaudhary,
Divyang M. Patel
RSC Advances,
Год журнала:
2024,
Номер
14(42), С. 31072 - 31116
Опубликована: Янв. 1, 2024
This
article
describes
recent
advances
in
one-pot
chemoselective
reactions
and
their
mechanism
insights.
Here,
the
substrate,
catalyst,
solvent,
temperature
play
a
vital
role
modulating
chemoselectivity.
Язык: Английский
Electrochemical Annulation of p-Alkoxy or p-Hydroxy Anilines with Enaminones for Selective Indole and Benzofuran Synthesis
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
The
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
p-methoxy/p-hydroxy
anilines
has
been
developed,
enabling
the
regioselective
synthesis
indoles
benzofurans.
methods
are
significant
advantage
not
only
due
to
mild
metal-free
conditions,
but
also
because
employment
easily
available
stable
aniline
substrates
replace
unstable
quinoneimide
for
a
similar
annulation
in
previous
work.
Язык: Английский
Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis propiophenones and their application in 3-methyl chromone synthesis
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
method
of
reducing
Язык: Английский
EDA-Enabled Three-Component Polarity-Crossover Cyclization: Modular Installation of Fully Substituted γ-Lactams
Organic Letters,
Год журнала:
2024,
Номер
26(44), С. 9598 - 9603
Опубликована: Окт. 28, 2024
A
photoinduced
three-component
radical
addition-aminalization
cascade
was
accomplished,
enabling
rapid
assembly
of
a
wide
range
densely
functionalized
γ-lactams.
Key
to
this
transformation
is
the
electron-donor-acceptor
(EDA)
generation
enamine
and
in
situ
trapping
an
iminium
intermediate
with
bromodifluoroacetamide.
This
rationally
designed
protocol
fully
takes
advantage
polarity
crossover
(enamine-iminium)
process,
providing
modular
previously
inaccessible
scaffolds.
The
reaction
proceeds
under
mild
conditions
excellent
regio-
diastereoselectivity,
which
amenable
structurally
varied
substrates
pharmaceuticals.
Язык: Английский