Oxygen Migration–Defluorination Strategy Enables the Aminocarbonylation of Enaminones with o-Aminobenzamides and CF₂Br₂

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The development of different concept approaches and user-friendly carbonyl surrogates for aminocarbonylation is highly desirable. Herein, we report the photocatalytic enaminones with easily available o-aminobenzamides CF2Br2 through an oxygen migration-defluorination strategy. reaction features switchable transformation construction carbamoyl-substituted enol products allows expedient synthesis fully substituted maleimides under mild conditions.

Language: Английский

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Transition metal-free thiophene construction in pure water by multiplied C-H functionalization with enaminones and elemental sulfur

Green Synthesis and Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Electrochemical Annulation of p-Alkoxy or p-Hydroxy Anilines with Enaminones for Selective Indole and Benzofuran Synthesis

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

The green and sustainable electrochemical oxidative cyclization of enaminones with p-methoxy/p-hydroxy anilines has been developed, enabling the regioselective synthesis indoles benzofurans. methods are significant advantage not only due to mild metal-free conditions, but also because employment easily available stable aniline substrates replace unstable quinoneimide for a similar annulation in previous work.

Language: Английский

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Recent trends for chemoselectivity modulation in one-pot organic transformations

RSC Advances, Journal Year: 2024, Volume and Issue: 14(42), P. 31072 - 31116

Published: Jan. 1, 2024

This article describes recent advances in one-pot chemoselective reactions and their mechanism insights. Here, the substrate, catalyst, solvent, temperature play a vital role modulating chemoselectivity.

Language: Английский

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Tandem site-selective bromination and highly regioselective Heck reaction of N-allyl enaminones: chemodivergent synthesis of polysubstituted pyrroles and pyridines

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5532 - 5537

Published: Jan. 1, 2024

Chemodivergent synthesis of polysubstituted pyrroles and pyridines from N -allyl enaminones via tandem site-selective bromination the highly regioselective Heck reaction.

Language: Английский

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EDA-Enabled Three-Component Polarity-Crossover Cyclization: Modular Installation of Fully Substituted γ-Lactams

Organic Letters, Journal Year: 2024, Volume and Issue: 26(44), P. 9598 - 9603

Published: Oct. 28, 2024

A photoinduced three-component radical addition-aminalization cascade was accomplished, enabling rapid assembly of a wide range densely functionalized γ-lactams. Key to this transformation is the electron-donor-acceptor (EDA) generation enamine and in situ trapping an iminium intermediate with bromodifluoroacetamide. This rationally designed protocol fully takes advantage polarity crossover (enamine-iminium) process, providing modular previously inaccessible scaffolds. The reaction proceeds under mild conditions excellent regio- diastereoselectivity, which amenable structurally varied substrates pharmaceuticals.

Language: Английский

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Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis propiophenones and their application in 3-methyl chromone synthesis

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A method of reducing

Language: Английский

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