Respiration aligns perception with neural excitability DOI Creative Commons
Daniel S. Kluger, Elio Balestrieri, Niko A. Busch

и другие.

eLife, Год журнала: 2021, Номер 10

Опубликована: Дек. 14, 2021

Recent studies from the field of interoception have highlighted link between bodily and neural rhythms during action, perception, cognition. The mechanisms underlying functional body-brain coupling, however, are poorly understood, as ways in which they modulate behavior. We acquired respiration human magnetoencephalography data a near-threshold spatial detection task to investigate trivariate relationship respiration, excitability, performance. Respiration was found significantly perceptual sensitivity well posterior alpha power (8–13 Hz), well-established proxy cortical excitability. In turn, suppression prior detected versus undetected targets underscored behavioral benefits heightened Notably, respiration-locked excitability changes were maximized at phase lag around –30° thus temporally preceded performance changes. line with interoceptive inference accounts, these results suggest that actively aligns sampling sensory information transient cycles facilitate

Язык: Английский

Breathing matters DOI
Christopher A. Del Negro, Gregory D. Funk, Jack L. Feldman

и другие.

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(6), С. 351 - 367

Опубликована: Май 8, 2018

Язык: Английский

Процитировано

569
Breathing coordinates cortico-hippocampal dynamics in mice during offline states DOI Creative Commons
Nikolaos Karalis, Anton Sirota

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Янв. 24, 2022

Network dynamics have been proposed as a mechanistic substrate for the information transfer across cortical and hippocampal circuits. However, little is known about mechanisms that synchronize coordinate these processes widespread brain regions during offline states. Here we address hypothesis breathing acts an oscillatory pacemaker, persistently coupling distributed circuit dynamics. Using large-scale recordings from number of subcortical in behaving mice, uncover presence intracerebral respiratory corollary discharge, modulates neural activity During states, modulation underlies sharp-wave ripples DOWN/UP state transitions, which mediates systems memory consolidation. These results highlight breathing, perennial rhythm, scaffold functional coordination limbic supports segregation integration flow neuronal networks

Язык: Английский

Процитировано

131
Breathing Rhythm and Pattern and Their Influence on Emotion DOI Open Access
Sufyan Ashhad, Kaiwen Kam, Christopher A. Del Negro

и другие.

Annual Review of Neuroscience, Год журнала: 2022, Номер 45(1), С. 223 - 247

Опубликована: Март 9, 2022

Breathing is a vital rhythmic motor behavior with surprisingly broad influence on the brain and body. The apparent simplicity of breathing belies complex neural control system, central pattern generator (bCPG), that exhibits diverse operational modes to regulate gas exchange coordinate an array behaviors. In this review, we focus selected advances in our understanding bCPG. At core bCPG preBötzinger (preBötC), which drives inspiratory rhythm via unexpectedly sophisticated emergent mechanism. Synchronization dynamics underlying preBötC rhythmogenesis imbue system robustness lability. These are modulated by inputs from throughout generate rhythmic, patterned activity widely distributed. connectivity emerging literature support link between breathing, emotion, cognition becoming experimentally tractable. bring great potential for elucidating function dysfunction other mammalian circuits.

Язык: Английский

Процитировано

88
Interoceptive rhythms in the brain DOI
Tahnée Engelen, Marco Solcà, Catherine Tallon‐Baudry

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(10), С. 1670 - 1684

Опубликована: Сен. 11, 2023

Язык: Английский

Процитировано

82
The integrated brain network that controls respiration DOI Creative Commons
Friedrich Krohn, Manuele Novello, Ruben S. van der Giessen

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Март 8, 2023

Respiration is a brain function on which our lives essentially depend. Control of respiration ensures that the frequency and depth breathing adapt continuously to metabolic needs. In addition, respiratory control network has organize muscular synergies integrate ventilation with posture body movement. Finally, coupled cardiovascular emotion. Here, we argue can handle this all by integrating brainstem central pattern generator circuit in larger also comprises cerebellum. Although currently not generally recognized as center, cerebellum well known for its coordinating modulating role motor behavior, autonomic nervous system. review, discuss regions involved respiration, their anatomical functional interactions. We how sensory feedback result adaptation these mechanisms be compromised various neurological psychological disorders. demonstrate generators are part integrated regions.

Язык: Английский

Процитировано

80
Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels DOI
Luna Jammal, Sebastian H. Bitzenhofer, Ileana L. Hanganu‐Opatz

и другие.

Science, Год журнала: 2024, Номер 383(6682)

Опубликована: Фев. 1, 2024

The transmission of the heartbeat through cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, elicited correlated local field oscillations in olfactory bulb mitral cell layer. These did not require synaptic but reflected baroreceptive transduction cells. This was mediated by fast excitatory mechanosensitive ion channel and modulated spiking awake animals, entrained activity subset neurons within ~20 milliseconds. Thus, we propose this fast, intrinsic interoceptive mechanism perception-for example, during arousal-within possibly across various other areas.

Язык: Английский

Процитировано

61
Brainstem control of vocalization and its coordination with respiration DOI
Jae Hong Park,

Seonmi Choi,

Jun Takatoh

и другие.

Science, Год журнала: 2024, Номер 383(6687)

Опубликована: Март 7, 2024

Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific premotor neurons located retroambiguus nucleus (RAm VOC ) adult mice as being both necessary and sufficient for driving vocal cord closure eliciting mouse ultrasonic vocalizations (USVs). The duration RAm activation can determine lengths USV syllables concurrent expiration periods, impact depending respiration phases. receive inhibition from preBötzinger complex, inspiration needs override -mediated closure. Ablating inhibitory synapses compromised this gating adduction, resulting discoordination vocalization Our study reveals circuits production vocal-respiratory coordination.

Язык: Английский

Процитировано

22
Differential impact of two critical respiratory centres in opioid‐induced respiratory depression in awake mice DOI Open Access
Adrienn G. Varga, Brandon T. Reid, Brigitte L. Kieffer

и другие.

The Journal of Physiology, Год журнала: 2019, Номер 598(1), С. 189 - 205

Опубликована: Окт. 7, 2019

Key points The main cause of death from opioid overdose is respiratory depression due to the activation µ‐opioid receptors (MORs). We conditionally deleted MORs neurons in two key areas brainstem circuitry (the Kölliker–Fuse nucleus (KF) and pre‐Bötzinger complex (preBötC)) determine their role opioid‐induced disturbances adult, awake mice. Deletion KF attenuated rate at all doses morphine. preBötC low dose, but had no effect on following high Instead, morphine increased occurrence apnoeas. results indicate that opioids affect distributed network a dose‐dependent manner countering effects dose via may be an effective approach combat overdose. Abstract primary failure. High severe risk fatal apnoea, which correlate with increasing irregularities breathing pattern. µ‐Opioid (MORs) are widely throughout network, mechanisms underlying poorly understood. medullary (preBötC) pontine considered critical for inducing opioid‐related disturbances. used conditional knockout investigate roles relative contribution adult revealed region‐specific control both Respiratory induced by anti‐nociceptive was significantly deletion either or preBötC, suggesting cumulative doses. also relieved near‐maximal depressant Meanwhile, administration ataxic pattern emerged many conclude cannot attributed only one area isolation. However, near maximal powerful

Язык: Английский

Процитировано

112
Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons DOI Creative Commons
Cindy F. Yang, Euiseok J. Kim, Edward M. Callaway

и другие.

Frontiers in Neuroanatomy, Год журнала: 2020, Номер 14

Опубликована: Сен. 4, 2020

The key driver of breathing rhythm is the preBötzinger Complex (preBötC) whose activity modulated by various functional inputs, e.g., volitional, physiological, and emotional. While preBötC highly interconnected with other regions central pattern generator (bCPG) in brainstem, there no data about direct projections to either excitatory inhibitory subpopulations from elements bCPG or suprapontine regions. Using modified rabies tracing, we identified neurons throughout brain that send monosynaptic mice. Within sites bCPG, including contralateral preBötC, Bötzinger Complex, nucleus solitary tract (NTS), parafacial region (pF

Язык: Английский

Процитировано

106
Respiration modulates oscillatory neural network activity at rest DOI Creative Commons
Daniel S. Kluger, Joachim Groß

PLoS Biology, Год журнала: 2021, Номер 19(11), С. e3001457 - e3001457

Опубликована: Ноя. 11, 2021

Despite recent advances in understanding how respiration affects neural signalling to influence perception, cognition, and behaviour, it is yet unclear what extent breathing modulates brain oscillations at rest. We acquired resting state magnetoencephalography (MEG) data from human participants investigate if, where, cyclically oscillatory amplitudes (2 150 Hz). Using measures of phase–amplitude coupling, we show respiration-modulated (RMBOs) across all major frequency bands. Sources these modulations spanned a widespread network cortical subcortical areas with distinct spectrotemporal modulation profiles. Globally, delta gamma band varied distance the head centre, stronger distal (versus central) sites. Overall, provide first comprehensive mapping RMBOs entire brain, highlighting respiration–brain coupling as fundamental mechanism shape processing within canonical respiratory control networks (RCNs).

Язык: Английский

Процитировано

94