Journal of Neurophysiology,
Год журнала:
2021,
Номер
125(5), С. 1899 - 1919
Опубликована: Апрель 7, 2021
Opioid-induced
respiratory
depression
(OIRD)
represents
the
primary
cause
of
death
associated
with
therapeutic
and
recreational
opioid
use.
Within
United
States,
rate
from
abuse
since
early
1990s
has
grown
disproportionally,
prompting
classification
as
a
nationwide
“epidemic.”
Since
this
time,
we
have
begun
to
unravel
many
fundamental
cellular
systems-level
mechanisms
opioid-related
death.
However,
factors
such
individual
vulnerability,
neuromodulatory
compensation,
redundancy
effects
across
central
peripheral
nervous
systems
created
barrier
concise,
integrative
view
OIRD.
review,
bring
together
multiple
perspectives
in
field
OIRD
create
an
overarching
viewpoint
what
know,
where
essential
topic
research
going
forward
into
future.
American Journal of Respiratory and Critical Care Medicine,
Год журнала:
2019,
Номер
201(1), С. 20 - 32
Опубликована: Авг. 22, 2019
Respiratory
drive,
the
intensity
of
respiratory
center's
output,
determines
effort
exerted
in
each
breath.
The
increasing
awareness
adverse
effects
both
strong
and
weak
efforts
during
mechanical
ventilation
on
patient
outcome
brings
attention
to
drive
critically
ill
patient.
Critical
illness
can
affect
patients'
through
multiple
pathways,
mainly
operating
three
feedback
systems:
cortical,
metabolic,
chemical.
chemical
system,
defined
as
response
output
changes
arterial
blood
gases
pH,
is
one
most
important
determinants
drive.
purpose
this
state-of-the-art
review
describe
patients,
tools
available
assess
at
bedside,
discuss
implications
altered
ventilation.
An
analysis
that
relates
carbon
dioxide
levels
with
brain's
stimulus
will
be
presented,
contrasting
responses
patient's
ability
generate
effective
alveolar
ventilation,
unassisted
breathing
different
modes
ventilatory
assist.
This
may
facilitate
comprehension
pathophysiology
patients.
As
we
aim
avoid
over-
under-assistance
considering
bedside
improve
clinical
assessment
management
ventilator.
Physiological Reviews,
Год журнала:
2022,
Номер
103(2), С. 1487 - 1564
Опубликована: Дек. 15, 2022
Of
all
the
organ
systems
in
body,
gastrointestinal
tract
is
most
complicated
terms
of
numbers
structures
involved,
each
with
different
functions,
and
types
signaling
molecules
utilized.
The
digestion
food
absorption
nutrients,
electrolytes,
water
occurs
a
hostile
luminal
environment
that
contains
large
diverse
microbiota.
At
core
regulatory
control
digestive
defensive
functions
enteric
nervous
system
(ENS),
complex
neurons
glia
gut
wall.
In
this
review,
we
discuss
1)
intrinsic
neural
involved
2)
how
ENS
interacts
immune
system,
microbiota,
epithelium
to
maintain
mucosal
defense
barrier
function.
We
highlight
developments
have
revolutionized
our
understanding
physiology
pathophysiology
control.
These
include
new
molecular
architecture
ENS,
organization
function
motor
circuits,
roles
glia.
explore
transduction
stimuli
by
enteroendocrine
cells,
regulation
intestinal
glia,
local
role
microbiota
regulating
structure
ENS.
Multifunctional
work
together
glial
macrophages,
interstitial
cells
integrating
an
array
signals
initiate
outputs
are
precisely
regulated
space
time
homeostasis.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Янв. 24, 2022
Network
dynamics
have
been
proposed
as
a
mechanistic
substrate
for
the
information
transfer
across
cortical
and
hippocampal
circuits.
However,
little
is
known
about
mechanisms
that
synchronize
coordinate
these
processes
widespread
brain
regions
during
offline
states.
Here
we
address
hypothesis
breathing
acts
an
oscillatory
pacemaker,
persistently
coupling
distributed
circuit
dynamics.
Using
large-scale
recordings
from
number
of
subcortical
in
behaving
mice,
uncover
presence
intracerebral
respiratory
corollary
discharge,
modulates
neural
activity
During
states,
modulation
underlies
sharp-wave
ripples
DOWN/UP
state
transitions,
which
mediates
systems
memory
consolidation.
These
results
highlight
breathing,
perennial
rhythm,
scaffold
functional
coordination
limbic
supports
segregation
integration
flow
neuronal
networks
Cell Reports Medicine,
Год журнала:
2023,
Номер
4(1), С. 100895 - 100895
Опубликована: Янв. 1, 2023
Controlled
breathwork
practices
have
emerged
as
potential
tools
for
stress
management
and
well-being.
Here,
we
report
a
remote,
randomized,
controlled
study
(NCT05304000)
of
three
different
daily
5-min
exercises
compared
with
an
equivalent
period
mindfulness
meditation
over
1
month.
The
breathing
conditions
are
(1)
cyclic
sighing,
which
emphasizes
prolonged
exhalations;
(2)
box
breathing,
is
equal
duration
inhalations,
breath
retentions,
(3)
hyperventilation
retention,
longer
inhalations
shorter
exhalations.
primary
endpoints
improvement
in
mood
anxiety
well
reduced
physiological
arousal
(respiratory
rate,
heart
rate
variability).
Using
mixed-effects
model,
show
that
breathwork,
especially
the
exhale-focused
produces
greater
(p
<
0.05)
reduction
respiratory
meditation.
Daily
sighing
has
promise
effective
exercise.
Annual Review of Neuroscience,
Год журнала:
2022,
Номер
45(1), С. 223 - 247
Опубликована: Март 9, 2022
Breathing
is
a
vital
rhythmic
motor
behavior
with
surprisingly
broad
influence
on
the
brain
and
body.
The
apparent
simplicity
of
breathing
belies
complex
neural
control
system,
central
pattern
generator
(bCPG),
that
exhibits
diverse
operational
modes
to
regulate
gas
exchange
coordinate
an
array
behaviors.
In
this
review,
we
focus
selected
advances
in
our
understanding
bCPG.
At
core
bCPG
preBötzinger
(preBötC),
which
drives
inspiratory
rhythm
via
unexpectedly
sophisticated
emergent
mechanism.
Synchronization
dynamics
underlying
preBötC
rhythmogenesis
imbue
system
robustness
lability.
These
are
modulated
by
inputs
from
throughout
generate
rhythmic,
patterned
activity
widely
distributed.
connectivity
emerging
literature
support
link
between
breathing,
emotion,
cognition
becoming
experimentally
tractable.
bring
great
potential
for
elucidating
function
dysfunction
other
mammalian
circuits.
