Melanopsin phototransduction: beyond canonical cascades DOI Creative Commons
Ely Contreras,

Alexis P. Nobleman,

Phyllis R. Robinson

и другие.

Journal of Experimental Biology, Год журнала: 2021, Номер 224(23)

Опубликована: Ноя. 29, 2021

Melanopsin is a visual pigment that expressed in small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs). It involved regulating non-image forming behaviors, such as circadian photoentrainment and the pupillary light reflex, while also playing role many aspects image-forming vision, contrast sensitivity. was initially discovered melanophores skin frog Xenopus, subsequently found rat, mouse primate retinas. ipRGCs were thought to be single cell population, melanopsin activate single, invertebrate-like Gq/transient receptor potential canonical (TRPC)-based phototransduction cascade within these cells. However, 20 years since discovery melanopsin, our knowledge this has expanded dramatically. Six ipRGC subtypes have now been identified mouse, each with unique morphological, physiological functional properties. Multiple other species, suggesting type diversity general feature system. This led renewed interest may not follow Gq/TRPC or plethora organisms express photopigment. In Review, we discuss recent findings discoveries challenged prevailing view pathway influences solely functions.

Язык: Английский

Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes DOI Creative Commons
Nicholas M. Tran, Karthik Shekhar,

Irene E. Whitney

и другие.

Neuron, Год журнала: 2019, Номер 104(6), С. 1039 - 1055.e12

Опубликована: Ноя. 26, 2019

Язык: Английский

Процитировано

532
Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior DOI Creative Commons
Michael Tri H.

Neuron, Год журнала: 2019, Номер 104(2), С. 205 - 226

Опубликована: Окт. 1, 2019

Язык: Английский

Процитировано

239
A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy DOI Creative Commons
Lu Huang, Yue Xi,

Yanfang Peng

и другие.

Neuron, Год журнала: 2019, Номер 102(1), С. 128 - 142.e8

Опубликована: Фев. 19, 2019

Язык: Английский

Процитировано

237
Spatial distribution and functional integration of displaced retinal ganglion cells DOI Creative Commons

Sabrina Duda,

Christoph T. Block,

Dipti R. Pradhan

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 28, 2025

Abstract The retina contains distinct types of ganglion cells, which form mosaics with cells each type at position the visual field. Displaced retinal (dRGCs) occur cell bodies in inner nuclear layer (INL), and regularly placed RGCs layer. An example mammalian dRGCs are M1-type intrinsically photosensitive (ipRGCs). Little is known, however, about their relationship ipRGCs. We identified mouse ipRGC M1, M2, M4/sONɑ by immunohistochemistry light microscopy. Reconstruction immunolabeled from M1 sONɑ indicated that tiled regular RGC partners. Multi-electrode array recordings revealed conventional receptive fields displaced fit into mosaic counterparts. distribution analysis showed type-specific dRGC patterns followed neither global density all nor local densities corresponding types. displacement INL occurs a type-dependent manner, where positioned to complete Our data suggest serve same functional role within population RGCs.

Язык: Английский

Процитировано

2
Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions DOI
Marcos L. Aranda, Tiffany M. Schmidt

Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 78(3), С. 889 - 907

Опубликована: Сен. 23, 2020

Язык: Английский

Процитировано

133
Circadian Photoentrainment in Mice and Humans DOI Creative Commons
F. Foster, Steven Hughes, Stuart N. Peirson

и другие.

Biology, Год журнала: 2020, Номер 9(7), С. 180 - 180

Опубликована: Июль 21, 2020

Light around twilight provides the primary entrainment signal for circadian rhythms. Here we review mechanisms and responses of mouse human systems to light. Both utilize a network photosensitive retinal ganglion cells (pRGCs) expressing photopigment melanopsin (OPN4). In both species action spectra functional expression OPN4 in vitro show that has λmax close 480 nm. Anatomical findings demonstrate there are multiple pRGC sub-types, with some evidence mice, but little humans, regarding their roles regulating physiology behavior. Studies non-human primates rods cones project can modulate light pRGCs. Such an integration signals enables detect dim light, higher intensities intermittent exposure, whilst measures bright over extended periods time. Although photoreceptor similar, sensitivity thresholds differ markedly between mice humans. Mice entrain at approximately 1 lux few minutes, humans require high irradiance (>100's lux) long duration (>30 min). The basis this difference remains unclear. As our exposure is highly dynamic, because interactions complex difficult model, attempts develop evidence-based lighting enhance very challenging. A way forward will be define artificial natural "real world" where intensity, duration, spectral quality, time day, history age each assessed.

Язык: Английский

Процитировано

121
Functional diversity of human intrinsically photosensitive retinal ganglion cells DOI Open Access
Ludovic S. Mure, Frans Vinberg, Anne Hanneken

и другие.

Science, Год журнала: 2019, Номер 366(6470), С. 1251 - 1255

Опубликована: Дек. 6, 2019

Sensing light without forming images In the rodent retina, intrinsically photosensitive retinal ganglion cells (ipRGCs) entrain circadian rhythms, modulate mood, and signal pupillary accommodation. Such responses are light-driven but not image-based. Working with donated human organ tissues, Mure et al. used electrophysiological approaches to identify ipRGCs in retina. The retina has more cones than retinas of nocturnal mice rats. Differences sensitivity, latency, duration identified three subtypes ipRGCs. Science , this issue p. 1251

Язык: Английский

Процитировано

112
Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep DOI Creative Commons
Alan C. Rupp, Michelle Ren,

Cara M. Altimus

и другие.

eLife, Год журнала: 2019, Номер 8

Опубликована: Июль 23, 2019

The light environment greatly impacts human alertness, mood, and cognition by both acute regulation of physiology indirect alignment circadian rhythms. These processes require the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), but relevant downstream brain areas involved remain elusive. ipRGCs project widely in brain, including to central pacemaker, suprachiasmatic nucleus (SCN). Here we show that body temperature sleep responses exposure are absent after genetic ablation all except a subpopulation projects SCN. Furthermore, chemogenetic activation avoid SCN, these sufficient for changes temperature. Our results challenge idea SCN is major relay effects on non-image forming behaviors identify sensory initiate light's profound sleep.

Язык: Английский

Процитировано

100
Cell-type-specific binocular vision guides predation in mice DOI Creative Commons

Keith P. Johnson,

Michael J. Fitzpatrick, Lei Zhao

и другие.

Neuron, Год журнала: 2021, Номер 109(9), С. 1527 - 1539.e4

Опубликована: Март 29, 2021

Язык: Английский

Процитировано

97
The Lighting Environment, Its Metrology, and Non-visual Responses DOI Creative Commons
Luc J. M. Schlangen, Luke Price

Frontiers in Neurology, Год журнала: 2021, Номер 12

Опубликована: Март 4, 2021

International standard CIE S 026:2018 provides lighting professionals and field researchers in chronobiology with a method to characterize light exposures respect non-visual photoreception responses. This defines five spectral sensitivity functions that describe optical radiation for its ability stimulate each of the α-opic retinal photoreceptor classes contribute effects humans via intrinsically-photosensitive ganglion cells (ipRGCs). The also recently published an open-access toolbox calculates all quantities ratios metrology photometric, radiometric photon systems, based on either measured (user-defined) spectrum or selected illuminants (A, D65, E, FL11, LED-B3) built into toolbox. For wide variety ecologically-valid conditions, melanopsin-based ipRGCs has been shown account responses, from shifting timing nocturnal sleep melatonin secretion regulating steady-state pupil diameter. Recent findings continue confirm photopigment melanopsin plays role visual may have significant influence brightness perception aspects spatial vision. Although knowledge concerning extent which rods cones interact driving is still growing, position statement used melanopic equivalent daylight (D65) illuminance preliminary guidance applying “proper at proper time” manipulate Further this approach awaited participants 2nd Workshop Circadian Neurophysiological Photometry (in Manchester, August 2019). new 026 enables traceable measurements formal, quantitative specification personal exposures, photic interventions designs. Here, we apply everyday sources including natural time series, range LED products and, using toobox, smartphone display screen. collection examples suggests ways variations content over day can be adopted strategies use support human health well-being.

Язык: Английский

Процитировано

88