Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities

Endocrinology, Год журнала: 2022, Номер 163(9)

Опубликована: Июль 21, 2022

Oxytocin and vasopressin are peptide hormones secreted from the pituitary that well known for their peripheral endocrine effects on childbirth/nursing blood pressure/urine concentration, respectively. However, both peptides also released in brain, where they modulate several aspects of social behaviors. promotes maternal nurturing bonding, enhances reward, increases salience stimuli. Vasopressin modulates communication, investigation, territorial behavior, aggression, predominantly males. Both facilitate memory pair bonding behaviors monogamous species. Here we review latest research delineating neural circuitry brain oxytocin systems summarize recent investigations into circuit-based mechanisms modulating We highlight using modern molecular genetic technologies to map, monitor activity of, or manipulate neuropeptide circuits. Species diversity discussed. conclude with a discussion translational implications improving functioning disorders impairments, such as autism spectrum disorder.

Язык: Английский

---

A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens

Frontiers in Neuroendocrinology, Год журнала: 2025, Номер unknown, С. 101175 - 101175

Опубликована: Янв. 1, 2025

Язык: Английский

---

The neural basis of affective empathy: what is known from rodents

Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110347 - 110347

Опубликована: Фев. 1, 2025

Язык: Английский

---

Oxytocin receptor controls promiscuity and development in prairie voles

Опубликована: Фев. 14, 2025

Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including monogamy prairie voles. How Oxtr regulates specific components of attachment and the neural mechanisms mediating them remains unknown. Here, we examine voles lacking demonstrate that pair bonding comprises distinct behavioral modules: preference for a bonded partner, rejection novel potential mates. Our longitudinal study shows sex-specifically early interactions between partners facilitating formation partner preference. Additionally, suppresses promiscuity towards mates following bonding, contributing to rejection. function coordinated patterns gene expression regions implicated oxytocin paraventricular nucleus hypothalamus, principal source oxytocin. Thus, controls genetically separable coordinates development substrates attachment.

Язык: Английский

---

Male, but not female, oxytocin receptor knockout prairie voles (Microtus ochrogaster) show impaired consolation behavior

Hormones and Behavior, Год журнала: 2025, Номер 169, С. 105708 - 105708

Опубликована: Фев. 17, 2025

Язык: Английский

---

Oxytocin, GABA, and dopamine interplay in autism

Endocrine Regulations, Год журнала: 2024, Номер 58(1), С. 105 - 114

Опубликована: Янв. 1, 2024

Oxytocin plays an important role in brain development and is associated with various neurotransmitter systems the brain. Abnormalities production, secretion, distribution of oxytocin brain, at least during some stages development, are critical for pathogenesis neuropsychiatric diseases, particularly autism spectrum disorder. The etiology includes changes local sensory dopaminergic areas which also supplied by hypothalamic sources oxytocin. It very to understand their mutual relationship. In this review, relationship several components system, gamma-aminobutyric acid (GABA) inhibitory neurotransmission alterations disorder discussed. Special attention has been paid results describing a reduced expression GABAergic markers context models autism. presumed that altered neurotransmission, due absence or dysfunction certain developmental stages, disinhibits signaling contributes symptoms.

Язык: Английский

---

Oxytocin receptor controls promiscuity and development in prairie voles

Опубликована: Фев. 14, 2025

Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including monogamy prairie voles. How Oxtr regulates specific components of attachment and the neural mechanisms mediating them remains unknown. Here, we examine voles lacking demonstrate that pair bonding comprises distinct behavioral modules: preference for a bonded partner, rejection novel potential mates. Our longitudinal study shows sex-specifically early interactions between partners facilitating formation partner preference. Additionally, suppresses promiscuity towards mates following bonding, contributing to rejection. function coordinated patterns gene expression regions implicated oxytocin paraventricular nucleus hypothalamus, principal source oxytocin. Thus, controls genetically separable coordinates development substrates attachment.

Язык: Английский

---

Oxytocin and Dopamine Receptor Expression: Cellular Level Implications for Pair Bonding

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Oxytocin ( Oxtr ) and dopamine Drd1 , Drd2 receptors provide a canonical example for how differences in neuromodulatory drive individual species-level behavioral variation. These systems exhibit striking functionally-relevant nucleus accumbens (NAc) expression across monogamous prairie voles Microtus ochrogaster promiscuous meadow pennsylvanicus ). However, their cellular organization remains largely unknown. Using multiplex situ hybridization, we mapped sexually naïve mate-paired voles. Prairie have more Oxtr+ cells than voles, but distribution dopamine-receptor cell class was similar, indicating general upregulation rather bias. enriched that express both Drd1+/Drd2+ suggesting these may be particularly sensitive to oxytocin. We found no species or pairing-induced Drd1+ Drd2+ counts, prior reports of reflect already expressing receptors. Finally, used single-nucleus sequencing the first comprehensive map Drd1-5 molecularly-defined NAc types vole. results critical framework understanding nonapeptide catecholamine recruit distinct shape social behavior.

Язык: Английский

---

Neural connectivity of oxytocin receptor-expressing neurons in the nucleus accumbens and their role in social attachment

Hormones and Behavior, Год журнала: 2025, Номер 171, С. 105726 - 105726

Опубликована: Март 29, 2025

Язык: Английский

---

Towards a Conceptual Framework to Better Understand the Advantages and Limitations of Model Organisms

European Journal of Neuroscience, Год журнала: 2025, Номер 61(7)

Опубликована: Март 31, 2025

ABSTRACT Model organisms (MO) are widely used in neuroscience to study brain processes, behavior, and the biological foundation of human diseases. However, use MO has also been criticized for low reliability insufficient success rate development therapeutic approaches, because led overoptimistic simplistic applications, which sometimes resulted wrong conclusions. Here, we develop a conceptual framework support scientists their practical work foster discussions about power limitations. For this purpose, take advantage concepts developed philosophy science adjust them application by neuroscientists. We suggest that can be best understood as tools gain information group species or phenomenon interest. These learning processes made possible some properties MO, facilitate process acquisition understanding provide advantages, possibility transfer between species. residual uncertainty remains, incorrect generalizations side‐effects epistemic benefits, consider representational risks. This suggests most effectively, should analyze similarity relation involved species, weigh advantages risks certain invest carefully designed validation experiments. Altogether, our analysis illustrates how benefit from philosophical research practice.

Язык: Английский

---