Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110442 - 110442
Опубликована: Апрель 1, 2025
Язык: Английский
British Journal of Pharmacology, Год журнала: 2023, Номер 180(S2)
Опубликована: Окт. 1, 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties approximately 1800 drug targets, and about 6000 interactions with 3900 ligands. There an emphasis on selective pharmacology (where available), plus links open access knowledgebase source targets their ligands ( https://www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes almost 500 pages, material presented substantially reduced compared information website. It a permanent, citable, point‐in‐time record that will survive database updates. full contents section can be found at http://onlinelibrary.wiley.com/doi/bph.16177 . G protein‐coupled receptors are one six major pharmacological into divided, others being: ion channels, nuclear hormone receptors, catalytic enzymes transporters. These nomenclature guidance summary best available tools, alongside references suggestions for further reading. landscape format designed facilitate comparison related from contemporary mid‐2023, supersedes data 2021/22, 2019/20, 2017/18, 2015/16 2013/14 Guides previous Receptors Channels. produced close conjunction Nomenclature Standards Committee International Union Basic Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification human where appropriate.
Язык: Английский
Процитировано
229
Metabolic Brain Disease, Год журнала: 2024, Номер 39(8), С. 1613 - 1636
Опубликована: Июль 31, 2024
Abstract This comprehensive review explores the intricate relationship between hypothalamic-pituitary-adrenal (HPA) axis, hypothalamic-pituitary-gonadal (HPG) and aggression. It provides a detailed overview of physiology functioning these axes, as well implications for aggressive behavior. The HPA responsible stress response, is activated in response to various stressors can influence Glucocorticoids, such cortisol, play crucial role stress-induced activation axis have been implicated tendencies. Chronic dysregulate leading alterations cortisol levels potentially contributing HPG particularly androgen hormone testosterone, also closely linked Animal human studies consistently shown positive association testosterone receptors brain’s neural circuitry critical modulating Interactions axes further contribute regulation Feedback mechanisms crosstalk provide complex system modulation both reproductive functions, which impact Additionally,the on androgens aggression, adds complexity this relationship. discusses future directions clinical interventions. Understanding neurobiological underlying aggression requires integrating molecular, cellular, circuit-level approaches. Translational perspectives, including animal models studies, bridge gap basic research applications. Finally, therapeutic strategies aggression-related disorders are explored, highlighting importance targeted interventions based understanding interactions axes. In conclusion, physiological with specific focus interplay By elucidating stress, hormones, behavior, paves way investigations potential disorders.
Язык: Английский
Процитировано
23
Biology, Год журнала: 2023, Номер 12(6), С. 844 - 844
Опубликована: Июнь 12, 2023
Love is a powerful emotional experience that rooted in ancient neurobiological processes shared with other species pair bond. Considerable insights have been gained into the neural mechanisms driving evolutionary antecedents of love by studies animal models bonding, particularly monogamous such as prairie voles (Microtus ochrogaster). Here, we provide an overview roles oxytocin, dopamine, and vasopressin regulating circuits responsible for generating bonds animals humans alike. We begin origins bonding mother–infant relationships then examine underpinnings each stage bonding. Oxytocin dopamine interact to link representation partner stimuli social reward courtship mating create nurturing bond between individuals. Vasopressin facilitates mate-guarding behaviors, potentially related human jealousy. further discuss psychological physiological stress following separation their adaptive function, well evidence positive health outcomes associated being pair-bonded based on both studies.
Язык: Английский
Процитировано
25
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Фев. 13, 2023
The neuropeptide arginine-vasopressin (AVP) is well known for its peripheral effects on blood pressure and antidiuresis. However, AVP also modulates various social anxiety-related behaviors by actions in the brain, often sex-specifically, with typically being stronger males than females. nervous system originates from several distinct sources which are, turn, regulated different inputs regulatory factors. Based both direct indirect evidence, we can begin to define specific role of cell populations behavior, such as, recognition, affiliation, pair bonding, parental mate competition, aggression, stress. Sex differences function may be apparent sexually-dimorphic structures as ones without prominent structural within hypothalamus. understanding how systems are organized ultimately lead better therapeutic interventions psychiatric disorders characterized deficits.
Язык: Английский
Процитировано
24
Journal of Psychopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Intranasal administration of oxytocin is emerging as a potential pharmacological option for mitigating social difficulties and regulating stress in autism spectrum disorder. However, initial single-dose multiple-dose trials showed mixed results, with some demonstrating improvements repetitive behavior others showing no benefit over placebo. This perspective aims to elucidate factors contributing this variability highlight pitfalls opportunities the field. We identified two major factors: design-related elements individual participant characteristics. Pertaining elements, optimal dosing regimens have yet be established, but appear favor moderate intervention durations (i.e., 4-6 weeks) intermittent intermediate 24-32 IU every other day). Also, context seems crucial, enhanced outcomes are mainly observed when paired socially stimulating supporting environment. In addition, more adequate outcome measures established effectively assess oxytocin's impact, including behavioral scales objective biophysiological markers tapping into neurophysiological regulation. Future research should also account differences biological sex, developmental stage cognitive adaptive functioning, incorporate (epi)genetic screening identify responders. Overall, refining study designs personalizing protocols essential optimizing prosocial anxiolytic effect autism.
Язык: Английский
Процитировано
1
Frontiers in Neuroendocrinology, Год журнала: 2025, Номер unknown, С. 101175 - 101175
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Hormones and Behavior, Год журнала: 2025, Номер 169, С. 105708 - 105708
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
1
Schizophrenia Bulletin, Год журнала: 2023, Номер 49(4), С. 867 - 880
Опубликована: Апрель 6, 2023
Social determinants of health (SDoHs) are nonmedical factors that significantly impact and longevity. We found no published reviews on the biology SDoHs in schizophrenia-spectrum psychotic disorders (SSPD).
Язык: Английский
Процитировано
20
Trends in Biochemical Sciences, Год журнала: 2024, Номер 49(4), С. 361 - 377
Опубликована: Фев. 27, 2024
Neurohypophysial peptides are ancient and evolutionarily highly conserved neuropeptides that regulate many crucial physiological functions in vertebrates invertebrates. The human neurohypophysial oxytocin/vasopressin (OT/VP) signaling system with its four receptors has become an attractive drug target for a variety of diseases, including cancer, pain, cardiovascular indications, neurological disorders. Despite promise, development faces hurdles, complexity, selectivity off-target concerns, translational interspecies differences, inefficient delivery. In this review we dive into the complexity OT/VP health disease, provide overview relevant pharmacological probes, discuss latest trends therapeutic lead discovery development.
Язык: Английский
Процитировано
7
Nature Neuroscience, Год журнала: 2024, Номер 27(8), С. 1565 - 1573
Опубликована: Июль 5, 2024
Язык: Английский
Процитировано
6