Cancers,
Год журнала:
2024,
Номер
16(18), С. 3156 - 3156
Опубликована: Сен. 14, 2024
Oral
cavity
and
lip
cancers
are
the
16th
most
common
cancer
in
world.
It
is
widely
known
that
a
lack
of
public
knowledge
about
precancerous
lesions,
oral
symptoms,
risk
factors
leads
to
diagnostic
delay
therefore
lower
survival
rate.
Risk
factors,
which
include
drinking
alcohol,
smoking,
HPV
infection,
pro-inflammatory
factor-rich
diet,
poor
hygiene,
must
be
avoided
by
general
population.
Regular
clinical
examinations
should
enriched
an
search
protocol
for
summarized
this
review.
Moreover,
new
methods,
some
already
available
(vital
tissue
staining,
optical
imaging,
cytology,
salivary
biomarkers,
artificial
intelligence,
colposcopy,
spectroscopy),
newly
researched
techniques
increase
likelihood
stopping
pathological
process
at
stage.
Well-established
treatments
(surgery,
radiotherapy,
chemotherapy,
immunotherapy)
continuously
being
developed
using
novel
technologies,
increasing
their
success
Additionally,
researched.
This
review
presents
glance
cancer—its
current
classification
epidemiology—and
will
provide
insights
into
development
methods
therapies.
Phytochemicals
have
a
long
and
successful
history
in
drug
discovery.
With
recent
advancements
analytical
techniques
methodologies,
discovering
bioactive
leads
from
natural
compounds
has
become
easier.
Computational
like
molecular
docking,
QSAR
modelling
machine
learning,
network
pharmacology
are
among
the
most
promising
new
tools
that
allow
researchers
to
make
predictions
concerning
products'
potential
targets,
thereby
guiding
experimental
validation
efforts.
Additionally,
approaches
LC-MS
or
LC-NMR
speed
up
compound
identification
by
streamlining
processes.
Integrating
structural
computational
biology
aids
lead
identification,
thus
providing
invaluable
information
understand
how
phytochemicals
interact
with
targets
body.
Emerging
approach
is
learning
involving
deep
neural
networks
interrelate
phytochemical
properties
diverse
physiological
activities
such
as
antimicrobial
anticancer
effects.
Biological and Clinical Sciences Research Journal,
Год журнала:
2020,
Номер
2020(1)
Опубликована: Дек. 12, 2020
Due
to
the
versatile
application
of
plants
utilization
and
their
inferred
substances
builds
up
day
by
for
revelation
new
curative
agents.
Conocarpus
erectus
has
placed
in
family
Combretaceae,
one
two
species
genus
ordinarily
exists
tropical
subtropical
regions
world.
In
some
countries
it
is
used
as
folk
medicine
fever,
anemia,
diabetes,
catarrh,
diarrhea
conjunctivitis.
The
current
study
was
carried
out
investigate
antibacterial
anticancer
properties
plant.
four
defatted
methanol
extracts
C.
different
parts
(leaves,
stems,
fruits
bark)
showed
high
activity
even
with
small
quantity
dose.
Antimicrobial
assay
check
against
6
bacterial
strains
Escherichia
coli,
Staphylococcus
Aureus
Klebstella
Pneumoniae.
results
show
that
gram
positive
bacteria
more
sensitivity
zone
inhibition
compared
negative
bacteria.
For
activity,
MTT
performed
on
HepG2
cells
this
purpose.
Plant
extorts
a
minute
quantity.
phytochemical
screening
extract
subjected
silica
gel
glass
column
go
behind
(RP-HPLC–UV–ESI-MS).
It
contains
phenol
such
tannin
flavinoid
major
component.
contain
Ellagic
acid;
di-hexahydroxy
diphenyl,
Vascalgin
isomer
foremost
Gallic
Acid,
Kaempferol
base
mass
spectra
time
retention.
shoot,
bark
&
fruit)
shows
antibacterial,
antioxidant
hepta-protective
activities
due
phenolic
content.
Tannin
than
other
compound.
C.erectus
notable
its
folkloristic
potential.
More
vivo
vitro
studies
are
needed
use
plant
prevention
treatment
many
diseases.
Increased
proliferation
of
bacterial
resistance
to
antibiotics
is
a
critical
issue
that
has
increased
the
demand
for
novel
antibacterial
compounds.
Antibacterial
activities
have
been
evaluated
in
extracts
from
photosynthetic
green
microalgae,
with
varying
levels
subsequent
potential
development
based
on
strain
algae,
pathogen,
and
solvent
used
extract
metabolites.
Green
microalgae
extreme
environmental
conditions
had
adapt
exclude
many
other
organisms.
The
production
compounds
aids
directly
or
indirectly
survival
these
environments,
as
well
potentially
serve
roles.
This
review
investigates
both
in-situ
induced
laboratory
highlights.
Key
words:
activity;
bioprospecting;
stress;
extracts;
Letters in Applied Microbiology,
Год журнала:
2021,
Номер
75(3), С. 476 - 499
Опубликована: Дек. 25, 2021
There
is
a
need
for
new
effective
antivirals,
particularly
in
response
to
the
development
of
antiviral
drug
resistance
and
emerging
RNA
viruses
such
as
SARS-CoV-2.
Plants
are
significant
source
structurally
diverse
bioactive
compounds
discovery
suggesting
that
plant-derived
natural
products
could
be
developed
agents.
This
article
reviews
activity
against
viruses,
with
focus
on
targeting
specific
stages
viral
life
cycle.
A
range
plant
extracts
have
been
identified
activity,
often
multiple
virus
families
they
may
useful
broad-spectrum
The
mechanism
action
many
these
phytochemicals
not
fully
understood
there
limited
studies
clinical
trials
demonstrating
their
efficacy
toxicity
vivo.
Further
research
needed
evaluate
therapeutic
potential
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Окт. 17, 2022
Natural
products,
those
molecules
derived
from
nature,
have
been
used
by
humans
for
thousands
of
years
to
treat
ailments
and
diseases.
More
recently,
these
compounds
inspired
chemists
use
natural
products
as
structural
templates
in
the
development
new
drug
molecules.
One
such
compound
is
leonurine,
a
molecule
isolated
characterized
tissues
Herb
leonuri
.
This
has
received
attention
scientists
recent
due
its
potent
anti-oxidant,
anti-apoptotic,
anti-inflammatory
properties.
recently
researchers
shown
leonurine
be
useful
treatment
cardiovascular
nervous
system
Like
other
paclitaxel
artemisinin,
historical
therapeutic
very
interesting.
Therefore,
this
review
provided
an
overview
product
discovery,
through
potential
drug.
Content
will
summarize
known
plant
sources,
pathway
synthesis
descriptions
leonurine’s
pharmacological
properties
mammalian
systems.
Medicinal Research Reviews,
Год журнала:
2023,
Номер
43(6), С. 2025 - 2085
Опубликована: Май 4, 2023
Abstract
The
high
incidence
of
oral
cancer
combined
with
excessive
treatment
cost
underscores
the
need
for
novel
preventive
and
therapeutic
options.
value
natural
agents,
including
plant
secondary
metabolites
(phytochemicals),
in
preventing
carcinogenesis
representing
expansive
source
anticancer
drugs
have
been
established.
While
fragmentary
research
data
are
available
on
antioral
effects
phytochemicals,
a
comprehensive
critical
evaluation
potential
these
agents
prevention
intervention
human
malignancies
has
not
conducted
according
to
our
knowledge.
This
study
presents
complete
analysis
current
preclinical
clinical
results
using
phytochemicals.
Our
in‐depth
highlights
various
such
as
phenolics,
terpenoids,
alkaloids,
sulfur‐containing
compounds,
against
numerous
cells
and/or
vivo
models
by
antiproliferative,
proapoptotic,
cell
cycle‐regulatory,
antiinvasive,
antiangiogenic,
antimetastatic
effects.
Bioactive
phytochemicals
exert
their
antineoplastic
modulating
signaling
pathways,
specifically
involving
epidermal
growth
factor
receptor,
cytokine
receptors,
toll‐like
tumor
necrosis
receptor
consequently
alter
expression
downstream
genes
proteins.
Interestingly,
demonstrate
encouraging
trials,
reduction
lesion
size,
growth,
pain
score,
development
new
lesions.
most
displayed
minimal
toxicity,
concerns
bioavailability
may
limit
application.
Future
directions
include
more
mechanistic
studies,
administration
formulations,
investigation
phytocompounds
adjuvants
conventional
treatment,
randomized
trials.
Synthesis,
Год журнала:
2023,
Номер
55(10), С. 1487 - 1496
Опубликована: Фев. 20, 2023
Abstract
The
evolution
of
methods
for
carbonyl
allylation
and
crotylation
alcohol
proelectrophiles
culminating
in
the
design
iodide-bound
ruthenium-JOSIPHOS
catalysts
is
prefaced
by
a
brief
historical
perspective
on
asymmetric
its
relevance
to
polyketide
construction.
Using
gaseous
allene
or
butadiene
as
precursors
allyl-
crotylruthenium
nucleophiles,
respectively,
new
capabilities
have
been
unlocked,
including
stereo-
site-selective
1,3-diols
related
polyols.
1
Introduction
Historical
Perspective
2
Ruthenium-Catalyzed
Conversion
Lower
Alcohols
into
Higher
3
Conclusion
Future
Outlook
Journal of Integrative Plant Biology,
Год журнала:
2023,
Номер
65(6), С. 1442 - 1466
Опубликована: Фев. 21, 2023
Plants
accumulate
a
vast
array
of
secondary
metabolites,
which
constitute
natural
resource
for
pharmaceuticals.
Oldenlandia
corymbosa
belongs
to
the
Rubiaceae
family,
and
has
been
used
in
traditional
medicine
treat
different
diseases,
including
cancer.
However,
active
metabolites
plant,
their
biosynthetic
pathway
mode
action
cancer
are
unknown.
To
fill
these
gaps,
we
exposed
this
plant
eight
stress
conditions
combined
omics
data
capturing
gene
expression,
metabolic
profiles,
anti-cancer
activity.
Our
results
show
that
O.
extracts
against
breast
cell
lines
ursolic
acid
is
responsible
Moreover,
assembled
high-quality
genome
uncovered
two
genes
involved
biosynthesis
acid.
Finally,
also
revealed
causes
mitotic
catastrophe
cells
identified
three
high-confidence
protein
binding
targets
by
Cellular
Thermal
Shift
Assay
(CETSA)
reverse
docking.
Altogether,
valuable
further
characterize
group,
while
will
allow
us
develop
compound.
Natural Product Reports,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
We
describe
the
pipeline
of
anticancer
agents
from
marine
cyanobacteria,
highlighting
critical
steps
discovery
towards
development,
including
identification
molecular
target
and
mechanism
action,
solving
supply
problem.
