Intramolecular direct arylation through mechanochemistry: efficient synthesis of corannulene-based peri-annulated curved nanographenes

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Язык: Английский

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Mechanochemistry of nucleosides, nucleotides and related materials

Beilstein Journal of Organic Chemistry, Год журнала: 2018, Номер 14, С. 955 - 970

Опубликована: Апрель 27, 2018

The application of mechanical force to induce the formation and cleavage covalent bonds is a rapidly developing field within organic chemistry which has particular value in reducing or eliminating solvent usage, enhancing reaction rates also enabling preparation products are otherwise inaccessible under solution-phase conditions. Mechanochemistry found recent attention materials API formulation during rearrangement non-covalent interactions give rise functional products. However, this been known nucleic acids science almost since its inception late nineteenth century when Miescher exploited grinding facilitate disaggregation DNA from tightly bound proteins through selective denaturation latter. Despite wide ball milling amino acid chemistry, there have limited reports mechanochemical transformations involving nucleoside nucleotide substrates on preparative scales. A survey these reactions provided, majority used mixer mill display an universal requirement for liquid be present vessel. charged substrates, particular, provides considerable benefits both terms efficiency (reducing total processing times weeks hours) by minimising exposure aqueous conditions, access previously elusive materials. In absence large quantities heating, side-reactions can reduced eliminated. central contribution mechanochemistry (and specifically, milling) isolation biologically active derived nuclei will outlined. Finally associative processes related using described: solid solutions, cocrystals, polymorph transitions, carbon nanotube dissolution inclusion complex formation.

Язык: Английский

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Mechanochemical Rhodium(III)‐ and Gold(I)‐Catalyzed C−H Bond Alkynylations of Indoles under Solventless Conditions in Mixer Mills

Angewandte Chemie International Edition, Год журнала: 2018, Номер 57(33), С. 10723 - 10727

Опубликована: Июнь 11, 2018

Abstract Mechanochemical activations in Rh III ‐ and Au I ‐catalyzed C−H alkynylations lead selectively to C 2 3 ‐alkynylated indoles. The processes show excellent functional group tolerance, do not require additional heating proceed under solventless conditions. Compared solvent‐based standard protocols, the reaction times are shorter catalyst quantities lower resulting high product yields ambient atmosphere mixer mills.

Язык: Английский

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Mechanochemie gasförmiger Reaktanten

Angewandte Chemie, Год журнала: 2018, Номер 131(11), С. 3320 - 3335

Опубликована: Ноя. 12, 2018

Abstract In den letzten Jahren hat sich die Anwendung von mechanischer Energie auf chemische Systeme wiederholt als vorteilhaft erwiesen, um Umwandlungen in verschiedenen Gebieten der Chemie zu erleichtern. Eine Vielzahl systematischen Studien belegt heute, dass Mechanochemie vielversprechende Möglichkeiten eröffnet, Synthese verändern. Nicht nur allein Fähigkeit, Herstellung Produkten ermöglichen, durch bestehende Methoden, wie reinen thermischen Aktivierung, unzugänglich sind, haben einer Anerkennung geführt. Man auch gemerkt, mechanochemische Reaktionen ihre nasschemischen Gegenstücke oft hinsichtlich Nachhaltigkeit übertreffen. Intuitiv sind meisten mechanochemischen Reaktionen, Kugelmahlen ausgeführt werden, mit Umwandlung Festkörpern und Flüssigkeiten verknüpft. allerdings Anzahl mechanochemischer gasförmigen Reaktanten zugenommen. Das Ziel dieses Kurzaufsatzes ist es daher, einerseits einen Überblick über geben, Gebrauch Proben Kugelmühlen beinhalten, andererseits Fortschritte Technologien Aufbauten aufzuzeigen, sicheren Umgang Reagenzien unter Bedingungen ermöglicht haben. Darüber hinaus werden Beispiele für aufgezeigt, an Grenzfläche Feststoff/Flüssigkeit/Gas–Gas stattfinden signifikanten Verbesserung Reaktivität oder Selektivität geführt Letztendlich hoffen wir zukünftige Arbeiten anzuregen, verbleibende Herausforderungen dem Gebiet anzugehen.

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Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

Molecules, Год журнала: 2020, Номер 25(16), С. 3579 - 3579

Опубликована: Авг. 6, 2020

One central challenge for XXI century chemists is the development of sustainable processes that do not represent a risk either to humanity or environment. In this regard, search more efficient and clean alternatives achieve chemical activation molecules involved in transformations has played prominent role recent years. The use microwave UV-Vis light irradiation, mechanochemical already widespread many laboratories. Nevertheless, an additional condition “green” comes from point view so-called atom economy. removal solvents reactions generally leads cleaner, economical processes. This review presents several illustrative applications protocols synthesis organic compounds under solvent-free reaction conditions.

Язык: Английский

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