Biological Research,
Год журнала:
2023,
Номер
56(1)
Опубликована: Июль 12, 2023
Since
the
discovery,
lipid
droplets
(LDs)
have
been
recognized
to
be
sites
of
cellular
energy
reserves,
providing
when
necessary
sustain
life
activities.
Many
studies
reported
large
numbers
LDs
in
eggs
and
early
embryos
from
insects
mammals.
The
questions
how
are
formed,
what
role
they
play,
their
significance
is
for
embryonic
development
attracting
attention
researchers.
Studies
recent
years
revealed
that
addition
development,
also
function
resist
lipotoxicity,
oxidative
stress,
inhibit
bacterial
infection,
provide
membrane
components
development.
Removal
fertilized
or
artificially
leads
developmental
arrest
defects.
This
paper
reviews
explain
effect
mechanisms
several
species
genes
involved
regulation.
review
contributes
understanding
mechanism
provides
new
insight
diagnosis
treatment
diseases
related
abnormalities.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Окт. 8, 2022
Abstract
Gastric
cancer
(GC)
ranks
fifth
in
global
diagnosis
and
fourth
cancer-related
death.
Despite
tremendous
progress
therapeutic
strategies
significant
improvements
patient
survival,
the
low
malignancy
stage
is
relatively
asymptomatic
many
GC
cases
are
diagnosed
at
advanced
stages,
which
leads
to
unsatisfactory
prognosis
high
recurrence
rates.
With
recent
advances
genome
analysis,
biomarkers
have
been
identified
that
clinical
importance
for
diagnosis,
treatment,
prognosis.
Modern
molecular
classifications
uncovered
vital
roles
signaling
pathways,
including
EGFR/HER2,
p53,
PI3K,
immune
checkpoint
cell
adhesion
molecules,
play
tumorigenesis,
progression,
metastasis,
responsiveness.
These
open
way
more
precise
diagnoses
treatments
patients.
Nevertheless,
relative
significance,
temporal
activation,
interaction
with
risk
factors,
crosstalk
between
these
pathways
not
well
understood.
Here,
we
review
regulatory
of
potential
biomarkers,
targets
an
emphasis
on
discoveries.
Current
therapies,
signaling-based
immunotherapies
exploited
past
decade,
development
treatment
GC,
particularly
challenges
developing
precision
medications,
discussed.
provide
a
direction
integration
clinical,
molecular,
genomic
profiles
improve
treatments.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Фев. 9, 2024
Abstract
Metastasis
accounts
for
90%
of
cancer-related
deaths
among
the
patients.
The
transformation
epithelial
cells
into
mesenchymal
with
molecular
alterations
can
occur
during
epithelial–mesenchymal
transition
(EMT).
EMT
mechanism
accelerates
cancer
metastasis
and
drug
resistance
ability
in
human
cancers.
Among
different
regulators
EMT,
Wnt/β-catenin
axis
has
been
emerged
as
a
versatile
modulator.
Wnt
is
active
form
physiological
condition
due
to
function
GSK-3β
that
destructs
β-catenin,
while
ligand–receptor
interaction
impairs
increase
β-catenin
stability
promote
its
nuclear
transfer.
Regarding
oncogenic
Wnt/β-catenin,
upregulation
occurs
cancers
it
accelerate
EMT-mediated
resistance.
stimulation
by
binding
ligands
Frizzled
receptors
enhance
accumulation
cytoplasm
stimulates
related
genes
upon
translocation.
Wnt/β-catenin/EMT
implicated
augmenting
both
solid
hematological
tumors.
Wnt/EMT-mediated
promotes
malignant
behavior
tumor
cells,
causing
therapy
be
modulated
upstream
mediators
which
non-coding
RNAs
are
main
regulators.
Moreover,
pharmacological
intervention,
mainly
using
phytochemicals,
suppresses
Wnt/EMT
suppression.
Graphical
abstract
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Июнь 18, 2024
Abstract
The
Wnt/β-catenin
signaling
pathway
plays
a
crucial
role
in
various
physiological
processes,
encompassing
development,
tissue
homeostasis,
and
cell
proliferation.
Under
normal
conditions,
the
is
meticulously
regulated.
However,
aberrant
activation
of
this
downstream
target
genes
can
occur
due
to
mutations
key
components
pathway,
epigenetic
modifications,
crosstalk
with
other
pathways.
Consequently,
these
dysregulations
contribute
significantly
tumor
initiation
progression.
Therapies
targeting
transduction
have
exhibited
promising
prospects
potential
for
treatment.
An
increasing
number
medications
are
continuously
being
developed
validated.
This
comprehensive
review
aims
summarize
latest
advances
our
understanding
played
by
carcinogenesis
targeted
therapy,
providing
valuable
insights
into
acknowledging
current
opportunities
challenges
associated
cancer
research
Epigenetics & Chromatin,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 15, 2025
Colorectal
cancer
(CRC)
remains
one
of
the
most
common
causes
cancer-related
mortality
worldwide.
Its
progression
is
influenced
by
complex
interactions
involving
genetic,
epigenetic,
and
environmental
factors.
Non-coding
RNAs
(ncRNAs),
including
microRNAs
(miRNAs),
long
non-coding
(lncRNAs),
circular
(circRNAs),
have
been
identified
as
key
regulators
gene
expression,
affecting
diverse
biological
processes,
notably
programmed
cell
death
(PCD).
This
review
aims
to
explore
relationship
between
ncRNAs
PCD
in
CRC,
focusing
on
how
influence
survival,
proliferation,
treatment
resistance.
A
comprehensive
literature
analysis
was
conducted
examine
recent
findings
role
modulating
various
mechanisms,
apoptosis,
autophagy,
necroptosis,
pyroptosis,
their
impact
CRC
development
therapeutic
response.
were
found
significantly
regulate
pathways,
impacting
tumor
growth,
metastasis,
sensitivity
CRC.
Their
these
pathways
highlights
potential
biomarkers
for
early
detection
targets
innovative
interventions.
Understanding
involvement
regulation
offers
new
insights
into
biology.
The
targeted
modulation
ncRNA-PCD
presents
promising
avenues
personalized
treatment,
which
may
improve
patient
outcomes
enhancing
effectiveness
reducing
Cell Death and Disease,
Год журнала:
2024,
Номер
15(3)
Опубликована: Март 1, 2024
Abstract
Tribbles
pseudokinase
3
(TRIB3)
has
been
identified
recently
as
a
novel
oncogene
in
several
cancers.
Still,
further
extensive
research
is
imperative
to
elucidate
its
function
and
the
molecular
mechanisms
underlying
involvement
progression
of
head
neck
squamous
cell
carcinoma
(HNSCC).
In
our
study,
we
found
that
TRIB3
silencing
significantly
promoted
death
by
inducing
ferroptosis.
The
interaction
with
Transcription
Factor
4
(TCF4)
β-catenin
created
heterotrimeric
complex,
which
directly
interacts
ALOXE3
promoter,
detrimentally
impacting
activation.
consequential
partial
neutralization
ferroptosis
induced
deficiency
observed
through
implementation
knockdown.
Furthermore,
study
demonstrated
inhibitor
hesperidin,
targeting
TRIB3,
not
only
reduced
malignancy
but
also
ferroptosis,
thereby
suppressing
tumor
growth.
Overall,
findings
unequivocally
validate
proposition
precipitates
iron
mechanism,
indicating
strategic
could
emerge
an
innovative
therapeutic
strategy
for
HNSCC.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Янв. 18, 2024
Abstract
One
of
the
key
features
cancer
is
energy
metabolic
reprogramming
which
tightly
related
to
proliferation,
invasion,
metastasis,
and
chemotherapy
resistance.
NcRNAs
are
a
class
RNAs
having
no
protein-coding
potential
mainly
include
microRNAs,
lncRNAs
circRNAs.
Accumulated
evidence
has
suggested
that
ncRNAs
play
an
essential
role
in
regulating
reprogramming,
altered
networks
mediated
by
primarily
drive
carcinogenesis
expression
enzymes
transporter
proteins.
Importantly,
accumulated
research
revealed
dysregulated
mediate
contributing
generation
therapeutic
tolerance.
Elucidating
molecular
mechanism
can
provide
promising
metabolism-related
targets
for
treatment
as
well
overcome
In
conclusion,
this
review
updates
latest
mechanisms
reprogramming.
