A spotlight on the role of copper in the epithelial to mesenchymal transition DOI Creative Commons

Antonio Focaccio,

Luisa Rossi, Anastasia De Luca

и другие.

Life Sciences, Год журнала: 2024, Номер 354, С. 122972 - 122972

Опубликована: Авг. 13, 2024

The complex process known as epithelial to mesenchymal transition (EMT) plays a fundamental role in several biological settings, encompassing embryonic development, wound healing, and pathological conditions such cancer fibrosis. In recent years, bulk of research has brought light the key copper, trace element with essential functions cellular metabolism, initiation progression. Indeed, besides functioning cofactor enzymes required for processes, energy production oxidation reactions, emerged an allosteric regulator kinases whose activity is fulfill dissemination through EMT. this comprehensive review, we try describe intricate relationship between metal copper EMT, spanning from earliest foundational studies latest advancements. Our aim shed on multifaceted roles undertaken by EMT unveil diverse mechanisms which homeostasis exerts its influence over regulators, signaling pathways, cell metabolic reprogramming transcription factors ultimately contributing spread cancer. Therefore, review not only may contribute deeper comprehension copper-mediated but also supports hypothesis that targeting counteract progression EMT-associated pathologies.

Язык: Английский

Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance DOI Creative Commons
Milad Ashrafizadeh,

Jingyuan Dai,

Pedram Torabian

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Май 11, 2024

The non-coding RNAs comprise a large part of human genome lack capacity in encoding functional proteins. Among various members RNAs, the circular (circRNAs) have been importance pathogenesis diseases, especially cancer. circRNAs unique closed loop structure and due to their stability, they are potential diagnostic prognostic factors increasing evidences highlighted role modulation proliferation metastasis cancer cells. On other hand, has responsible for up 90% cancer-related deaths patients, requiring more investigation regarding underlying mechanisms modulating this mechanism. EMT enhances invasion tumor cells, can trigger resistance therapy. cells demonstrate dynamic changes during including transformation from epithelial phenotype into mesenchymal increase N-cadherin vimentin levels. process is reversible its reprogramming disrupt progression aim current review understanding interaction cancers such beyond regulation affect response chemotherapy radiotherapy. onco-suppressor inhibit EMT, while tumor-promoting mediate acceleration carcinogenesis. Moreover, EMT-inducing transcription be controlled by different tumors.

Язык: Английский

Процитировано

60

Versatile function of NF-ĸB in inflammation and cancer DOI Creative Commons
Qiang Ma, Shuai Hao, Weilong Hong

и другие.

Experimental Hematology and Oncology, Год журнала: 2024, Номер 13(1)

Опубликована: Июль 16, 2024

Abstract Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, stemness. The function of NF-ĸB cancer progression response to chemotherapy has gained increasing attention. This review highlights the inflammation control, biological mechanisms, therapeutic implications treatment. is instrumental altering release inflammatory factors TNF-α, IL-6, IL-1β, which are key regulation carcinogenesis. Specifically, conditions including colitis, upregulation can intensify inflammation, potentially leading development colorectal cancer. Its pivotal extends regulating tumor microenvironment, impacting components macrophages, fibroblasts, T cells, natural killer cells. influences tumorigenesis dampen anti-tumor responses. Additionally, modulates death notably by inhibiting apoptosis ferroptosis. It also dual stimulating or suppressing autophagy cancers. Beyond these functions, controlling stem fostering angiogenesis, metastatic potential through EMT induction, reducing sensitivity radiotherapy. Given its oncogenic capabilities, research focused on products small molecule compounds that suppress NF-ĸB, offering promising avenues for therapy.

Язык: Английский

Процитировано

27

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

и другие.

Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Язык: Английский

Процитировано

26

Complex roles of autophagy in cancer development, immune evasion, and drug resistance DOI

Xuegang Niu,

Qi Sheng You, Kejun Hou

и другие.

Drug Resistance Updates, Год журнала: 2024, Номер 78, С. 101170 - 101170

Опубликована: Ноя. 15, 2024

Язык: Английский

Процитировано

24

Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy DOI
Songsong Wu,

Zhumin Cao,

Ruinan Lu

и другие.

Cytokine & Growth Factor Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

4

Oral Cancer Stem Cells: A Comprehensive Review of Key Drivers of Treatment Resistance and Tumor Recurrence DOI

P J Nagarathna,

Santosh Patil, Vishnu Priya Veeraraghavan

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177222 - 177222

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

3

Metastasis and chemoresistance in breast cancer: Crucial function of ZEB1/2 proteins DOI

Seyed Mohammad Doodmani,

Majid Safari, Mohammadarian Akbari

и другие.

Pathology - Research and Practice, Год журнала: 2025, Номер 267, С. 155838 - 155838

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

3

Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis DOI Creative Commons
Xiaohao Wang, Zechao Qu, Song‐Chuan Zhao

и другие.

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Окт. 28, 2024

Abstract Osteoblasts are mainly derived from mesenchymal stem cells in the bone marrow. These can differentiate into osteoblasts, which have functions of secreting matrix, promoting formation, and participating remodeling. The abnormality osteoblasts cause a variety bone-related diseases, including osteoporosis, delayed fracture healing, skeletal deformities. In recent years, with side effects caused by application PTH drugs, biphosphonate calmodulin people carried out more in-depth research on mechanism osteoblast differentiation, actively looking for natural compounds treatment osteoporosis. Wnt/β-catenin signaling pathway is considered to be one important pathways has become an target pathway, whether its activation enhanced or expression weakened, will diseases tumors. This review summarize effect differentiation correlation between related proteins human diseases. At same time, latest progress targeting against osteoporosis summarized.

Язык: Английский

Процитировано

11

Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis DOI Creative Commons
Yu Tian, Meng Zhang, Lixia Liu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related deaths in the world. The development and progression of HCC are closely correlated with abnormal regulation non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long (lncRNAs), circular (circRNAs). Important biological pathways cancer biology, cell proliferation, death, metastasis, impacted by these ncRNAs, which modulate gene expression. expression raises possibility that they could be applied new biomarkers for diagnosis, prognosis, treatment targets. Furthermore, controlling genes, miRNAs can function either tumor suppressors or oncogenes. On other hand, lncRNAs play role advancement interacting molecules within cell, which, turn, affects processes chromatin remodeling, transcription, post-transcriptional processes. importance ncRNA-driven regulatory systems being highlighted current research, sheds light on behavior therapy response. This research highlights great potential ncRNAs improve patient outcomes this difficult disease landscape augmenting present methods care through use precision medicine approaches.

Язык: Английский

Процитировано

10

Tumor Microenvironment Responsive Key Nanomicelles for Effective Against Invasion and Metastasis in Ovarian Cancer Using Mice Model DOI Creative Commons
Yang Liu,

Liang Kong,

Yang Yu

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 215 - 238

Опубликована: Янв. 1, 2025

Background: Ovarian cancer is difficult to detect in its early stages, and it has a high potential for invasion metastasis, along with rate of recurrence. These factors contribute the poor prognosis reduced survival times patients this disease. The effectiveness conventional chemoradiotherapy remains limited. Nano-particles, as novel drug delivery system, have significant improving therapeutic efficacy overcoming these challenges. Methods: According expression level matrix metalloproteinase-2 (MMP-2) tumor microenvironment, MMP-2 responsive nano-particles (PVGLIG-MTX-D/T-NMs) containing docetaxel triptolide were prepared by thin-film dispersion method. synergistic effect between was systematically investigated, ratio two drugs optimized, physicochemical properties their ability inhibit ovarian cell growth metastasis evaluated vitro vivo. Results: PVGLIG-MTX-D/T-NMs enhanced targeting, stability, bioavailability drug, while reducing dose toxicity. In addition, regulating levels E-Cadherin, N-Cadherin, metalloproteinases (MMPs), hypoxia-inducible factor 1-alpha (HIF-1α), vascular endothelial (VEGF), exhibited an inhibitory on epithelial-mesenchymal transformation (EMT) angiogenesis, effectively inhibited cells. Conclusion: achieved passive targeting sites enhancing permeability retention (EPR) effects. Subsequently, uptake cells responsiveness modification methotrexate ligands. By invasion- metastasis-related proteins tissues, affected EMT process, suppressed malignant cancer. findings provided new direction further exploration tumor-targeted therapy. Keywords: nano-drug docetaxel, triptolide, epithelial mesenchymal transition, angiogenesis

Язык: Английский

Процитировано

2