Life Sciences,
Год журнала:
2024,
Номер
354, С. 122972 - 122972
Опубликована: Авг. 13, 2024
The
complex
process
known
as
epithelial
to
mesenchymal
transition
(EMT)
plays
a
fundamental
role
in
several
biological
settings,
encompassing
embryonic
development,
wound
healing,
and
pathological
conditions
such
cancer
fibrosis.
In
recent
years,
bulk
of
research
has
brought
light
the
key
copper,
trace
element
with
essential
functions
cellular
metabolism,
initiation
progression.
Indeed,
besides
functioning
cofactor
enzymes
required
for
processes,
energy
production
oxidation
reactions,
emerged
an
allosteric
regulator
kinases
whose
activity
is
fulfill
dissemination
through
EMT.
this
comprehensive
review,
we
try
describe
intricate
relationship
between
metal
copper
EMT,
spanning
from
earliest
foundational
studies
latest
advancements.
Our
aim
shed
on
multifaceted
roles
undertaken
by
EMT
unveil
diverse
mechanisms
which
homeostasis
exerts
its
influence
over
regulators,
signaling
pathways,
cell
metabolic
reprogramming
transcription
factors
ultimately
contributing
spread
cancer.
Therefore,
review
not
only
may
contribute
deeper
comprehension
copper-mediated
but
also
supports
hypothesis
that
targeting
counteract
progression
EMT-associated
pathologies.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Май 11, 2024
The
non-coding
RNAs
comprise
a
large
part
of
human
genome
lack
capacity
in
encoding
functional
proteins.
Among
various
members
RNAs,
the
circular
(circRNAs)
have
been
importance
pathogenesis
diseases,
especially
cancer.
circRNAs
unique
closed
loop
structure
and
due
to
their
stability,
they
are
potential
diagnostic
prognostic
factors
increasing
evidences
highlighted
role
modulation
proliferation
metastasis
cancer
cells.
On
other
hand,
has
responsible
for
up
90%
cancer-related
deaths
patients,
requiring
more
investigation
regarding
underlying
mechanisms
modulating
this
mechanism.
EMT
enhances
invasion
tumor
cells,
can
trigger
resistance
therapy.
cells
demonstrate
dynamic
changes
during
including
transformation
from
epithelial
phenotype
into
mesenchymal
increase
N-cadherin
vimentin
levels.
process
is
reversible
its
reprogramming
disrupt
progression
aim
current
review
understanding
interaction
cancers
such
beyond
regulation
affect
response
chemotherapy
radiotherapy.
onco-suppressor
inhibit
EMT,
while
tumor-promoting
mediate
acceleration
carcinogenesis.
Moreover,
EMT-inducing
transcription
be
controlled
by
different
tumors.
Experimental Hematology and Oncology,
Год журнала:
2024,
Номер
13(1)
Опубликована: Июль 16, 2024
Abstract
Nuclear
factor-kappaB
(NF-ĸB)
plays
a
crucial
role
in
both
innate
and
adaptive
immune
systems,
significantly
influencing
various
physiological
processes
such
as
cell
proliferation,
migration,
differentiation,
survival,
stemness.
The
function
of
NF-ĸB
cancer
progression
response
to
chemotherapy
has
gained
increasing
attention.
This
review
highlights
the
inflammation
control,
biological
mechanisms,
therapeutic
implications
treatment.
is
instrumental
altering
release
inflammatory
factors
TNF-α,
IL-6,
IL-1β,
which
are
key
regulation
carcinogenesis.
Specifically,
conditions
including
colitis,
upregulation
can
intensify
inflammation,
potentially
leading
development
colorectal
cancer.
Its
pivotal
extends
regulating
tumor
microenvironment,
impacting
components
macrophages,
fibroblasts,
T
cells,
natural
killer
cells.
influences
tumorigenesis
dampen
anti-tumor
responses.
Additionally,
modulates
death
notably
by
inhibiting
apoptosis
ferroptosis.
It
also
dual
stimulating
or
suppressing
autophagy
cancers.
Beyond
these
functions,
controlling
stem
fostering
angiogenesis,
metastatic
potential
through
EMT
induction,
reducing
sensitivity
radiotherapy.
Given
its
oncogenic
capabilities,
research
focused
on
products
small
molecule
compounds
that
suppress
NF-ĸB,
offering
promising
avenues
for
therapy.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 10, 2024
Hepatocellular
carcinoma
(HCC)
is
a
significant
contributor
to
cancer-related
deaths
in
the
world.
The
development
and
progression
of
HCC
are
closely
correlated
with
abnormal
regulation
non-coding
RNAs
(ncRNAs),
such
as
microRNAs
(miRNAs),
long
(lncRNAs),
circular
(circRNAs).
Important
biological
pathways
cancer
biology,
cell
proliferation,
death,
metastasis,
impacted
by
these
ncRNAs,
which
modulate
gene
expression.
expression
raises
possibility
that
they
could
be
applied
new
biomarkers
for
diagnosis,
prognosis,
treatment
targets.
Furthermore,
controlling
genes,
miRNAs
can
function
either
tumor
suppressors
or
oncogenes.
On
other
hand,
lncRNAs
play
role
advancement
interacting
molecules
within
cell,
which,
turn,
affects
processes
chromatin
remodeling,
transcription,
post-transcriptional
processes.
importance
ncRNA-driven
regulatory
systems
being
highlighted
current
research,
sheds
light
on
behavior
therapy
response.
This
research
highlights
great
potential
ncRNAs
improve
patient
outcomes
this
difficult
disease
landscape
augmenting
present
methods
care
through
use
precision
medicine
approaches.
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Окт. 28, 2024
Abstract
Osteoblasts
are
mainly
derived
from
mesenchymal
stem
cells
in
the
bone
marrow.
These
can
differentiate
into
osteoblasts,
which
have
functions
of
secreting
matrix,
promoting
formation,
and
participating
remodeling.
The
abnormality
osteoblasts
cause
a
variety
bone-related
diseases,
including
osteoporosis,
delayed
fracture
healing,
skeletal
deformities.
In
recent
years,
with
side
effects
caused
by
application
PTH
drugs,
biphosphonate
calmodulin
people
carried
out
more
in-depth
research
on
mechanism
osteoblast
differentiation,
actively
looking
for
natural
compounds
treatment
osteoporosis.
Wnt/β-catenin
signaling
pathway
is
considered
to
be
one
important
pathways
has
become
an
target
pathway,
whether
its
activation
enhanced
or
expression
weakened,
will
diseases
tumors.
This
review
summarize
effect
differentiation
correlation
between
related
proteins
human
diseases.
At
same
time,
latest
progress
targeting
against
osteoporosis
summarized.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 215 - 238
Опубликована: Янв. 1, 2025
Background:
Ovarian
cancer
is
difficult
to
detect
in
its
early
stages,
and
it
has
a
high
potential
for
invasion
metastasis,
along
with
rate
of
recurrence.
These
factors
contribute
the
poor
prognosis
reduced
survival
times
patients
this
disease.
The
effectiveness
conventional
chemoradiotherapy
remains
limited.
Nano-particles,
as
novel
drug
delivery
system,
have
significant
improving
therapeutic
efficacy
overcoming
these
challenges.
Methods:
According
expression
level
matrix
metalloproteinase-2
(MMP-2)
tumor
microenvironment,
MMP-2
responsive
nano-particles
(PVGLIG-MTX-D/T-NMs)
containing
docetaxel
triptolide
were
prepared
by
thin-film
dispersion
method.
synergistic
effect
between
was
systematically
investigated,
ratio
two
drugs
optimized,
physicochemical
properties
their
ability
inhibit
ovarian
cell
growth
metastasis
evaluated
vitro
vivo.
Results:
PVGLIG-MTX-D/T-NMs
enhanced
targeting,
stability,
bioavailability
drug,
while
reducing
dose
toxicity.
In
addition,
regulating
levels
E-Cadherin,
N-Cadherin,
metalloproteinases
(MMPs),
hypoxia-inducible
factor
1-alpha
(HIF-1α),
vascular
endothelial
(VEGF),
exhibited
an
inhibitory
on
epithelial-mesenchymal
transformation
(EMT)
angiogenesis,
effectively
inhibited
cells.
Conclusion:
achieved
passive
targeting
sites
enhancing
permeability
retention
(EPR)
effects.
Subsequently,
uptake
cells
responsiveness
modification
methotrexate
ligands.
By
invasion-
metastasis-related
proteins
tissues,
affected
EMT
process,
suppressed
malignant
cancer.
findings
provided
new
direction
further
exploration
tumor-targeted
therapy.
Keywords:
nano-drug
docetaxel,
triptolide,
epithelial
mesenchymal
transition,
angiogenesis
Cancers,
Год журнала:
2025,
Номер
17(2), С. 228 - 228
Опубликована: Янв. 12, 2025
Triple-negative
breast
cancer
(TNBC)
is
one
of
the
most
difficult
subtypes
to
treat
due
its
distinct
clinical
and
molecular
characteristics.
Patients
with
TNBC
face
a
high
recurrence
rate,
an
increased
risk
metastasis,
lower
overall
survival
compared
other
subtypes.
Despite
advancements
in
targeted
therapies,
traditional
chemotherapy
(primarily
using
platinum
compounds
taxanes)
continues
be
standard
treatment
for
TNBC,
often
limited
long-term
efficacy.
tumors
are
heterogeneous,
displaying
diverse
mutation
profile
considerable
chromosomal
instability,
which
complicates
therapeutic
interventions.
The
development
chemoresistance
frequently
associated
process
epithelial–mesenchymal
transition
(EMT),
during
epithelial
tumor
cells
acquire
mesenchymal-like
phenotype.
This
shift
enhances
metastatic
potential,
while
simultaneously
reducing
effectiveness
chemotherapeutics.
It
has
also
been
suggested
that
EMT
plays
central
role
stem
cells.
Hence,
there
growing
interest
exploring
small-molecule
inhibitors
target
as
future
strategy
overcoming
resistance
improving
outcomes
patients
TNBC.
review
focuses
on
progression
drug
emphasis
these
processes.
We
present
TNBC-specific
EMT-related
features,
key
protein
markers,
various
signaling
pathways
involved.
discuss
important
mechanisms
factors
related
within
context
EMT,
highlighting
improve
patients’
outcomes.
