Cancer Letters, Год журнала: 2024, Номер unknown, С. 217388 - 217388
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Июнь 6, 2024
Abstract Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic pathway in 2012, ferroptosis has emerged crucial mechanism numerous physiological pathological contexts, leading to significant therapeutic advancements across wide range diseases. This review summarizes the fundamental mechanisms regulatory pathways underlying ferroptosis, including both GPX4-dependent -independent antioxidant mechanisms. Additionally, we examine involvement various conditions, cancer, neurodegenerative diseases, sepsis, ischemia–reperfusion injury, autoimmune disorders, metabolic disorders. Specifically, explore role response chemotherapy, radiotherapy, immunotherapy, nanotherapy, targeted therapy. Furthermore, discuss pharmacological strategies for modulating potential biomarkers monitoring this process. Lastly, elucidate interplay between other forms regulated death. Such insights hold promise advancing our understanding context human health disease.
Язык: Английский
Процитировано
45
Archives of Toxicology, Год журнала: 2024, Номер 98(4), С. 1025 - 1041
Опубликована: Фев. 21, 2024
Язык: Английский
Процитировано
26
Free Radical Biology and Medicine, Год журнала: 2024, Номер 213, С. 150 - 163
Опубликована: Янв. 6, 2024
Язык: Английский
Процитировано
25
Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11
Опубликована: Авг. 4, 2023
Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various exist, including surgery, radiotherapy, chemotherapy, immunotherapy combination therapies, there remains need develop therapies that target regulated cell death pathways eliminate cancer cells while preserving normal cells. Alkaliptosis, pH-dependent process triggered by small molecular compound JTC801, has been identified as novel approach malignant tumor treatment, particularly in pancreatic cancer. Two signaling pathways, NF-κB-CA9 pathway ATP6V0D1-STAT3 pathway, contribute induction of alkaliptosis. This review summarizes recent developments our understanding alkaliptosis signals, mechanisms, modulation, explores its context-dependent effects on drug resistance, inflammation, immunity. By providing deeper heterogeneity plasticity this information holds promise informing design more anti-tumor therapies.
Язык: Английский
Процитировано
28
Cancer Gene Therapy, Год журнала: 2024, Номер 31(3), С. 349 - 363
Опубликована: Янв. 4, 2024
Язык: Английский
Процитировано
12
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(4), С. 2238 - 2263
Опубликована: Фев. 2, 2024
Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation iron metabolism and accumulation lipid peroxides. This nonapoptotic mode implicated in various physiological pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. article focuses on ferroptosis-based therapeutic strategies precision covering molecular mechanisms ferroptosis, four major types ferroptosis inducers their inhibitory effects diverse carcinomas, detection fluorescent probes, implementation image-guided therapy. These state-of-the-art tactics manifested enhanced selectivity efficacy malignant carcinomas. Given administration therapy still at burgeoning stage, some challenges future perspectives discussed clinical translation into treatment.
Язык: Английский
Процитировано
12
Cancer Letters, Год журнала: 2024, Номер 590, С. 216826 - 216826
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
11
Cancer Research, Год журнала: 2024, Номер 84(6), С. 796 - 797
Опубликована: Янв. 26, 2024
Abstract Colorectal cancer is a prevalent type in the United States, affecting both genders and influenced by genetics environmental factors. The role of gut microbiome colorectal development therapy response burgeoning field study. A recent study uncovered that trans-3-indoleacrylic acid (IDA), microbial metabolite from P. anaerobius, promotes inhibiting ferroptosis, nonapoptotic cell death driven unrestricted lipid peroxidation subsequent membrane damage. IDA activates aryl hydrocarbon receptor (AHR), nuclear transcription factor, leading to expression aldehyde dehydrogenase 1 family member A3 (ALDH1A3). ALDH1A3, known for detoxification, also contributes ferroptosis resistance generating reduced nicotinamide adenine dinucleotide (NADH), critical synthesis coenzyme Q10 (COQH10), apoptosis-inducing factor mitochondria-associated 2 (AIFM2, as FSP1). Knocking out AHR, AIFM2, or ALDH1A3 reverses inhibitory effect on IDA-mediated tumor growth. Significantly, anaerobius enriched patients with cancer, supplementing accelerates progression spontaneous orthotopic mouse models. Taken together, these findings suggest targeting anaerobius–mediated emerges promising strategy combat development.
Язык: Английский
Процитировано
8
Molecular Carcinogenesis, Год журнала: 2024, Номер 63(8), С. 1515 - 1527
Опубликована: Май 15, 2024
Abstract Paclitaxel serves as the cornerstone chemotherapy for ovarian cancer, yet its prolonged administration frequently culminates in drug resistance, presenting a substantial challenge. Here we reported that inducing alkaliptosis, rather than apoptosis or ferroptosis, effectively overcomes paclitaxel resistance. Mechanistically, ATPase H + transporting V0 subunit D1 (ATP6V0D1), key regulator of plays pivotal role by mediating downregulation ATP‐binding cassette subfamily B member 1 (ABCB1), multidrug resistance protein. Both ATP6V0D1 overexpression through gene transfection and pharmacological enhancement protein stability using JTC801 inhibit ABCB1 upregulation, resulting growth inhibition drug‐resistant cells. Additionally, increasing intracellular pH to alkaline (pH 8.5) via sodium hydroxide application suppresses expression, whereas reducing acidic conditions 6.5) with hydrochloric acid amplifies expression Collectively, these results indicate potentially effective therapeutic strategy targeting paclitaxel‐resistant cancer ATP6V0D1‐dependent alkaliptosis.
Язык: Английский
Процитировано
8
Free Radical Biology and Medicine, Год журнала: 2023, Номер 208, С. 530 - 544
Опубликована: Сен. 17, 2023
Язык: Английский
Процитировано
20