Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 150, С. 105210 - 105210

Опубликована: Май 3, 2023

Язык: Английский

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Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 17, 2025

Although childhood maltreatment (CM) is widely recognized as a transdiagnostic risk factor for various internalizing and externalizing psychological disorders, the neural basis underlying this association remain unclear. The potential reasons inconsistent findings may be attributed to involvement of both common specific pathways that mediate influence on emergence psychopathological conditions. This study aimed delineate distinct linking depression aggression. First, we employed Network-Based Statistics (NBS) resting-state functional magnetic resonance imaging (fMRI) data identify connectivity (FC) patterns associated with Mediation analyses were then conducted assess role these FC in relationship between each outcome. results demonstrated within default mode network (DMN) cingulo-opercular (CON) dorsal attention (DAN) mediated aggression, whereas reward system CON link depression. We speculate control serve accounting sequela maltreatment, act respectively.

Язык: Английский

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The environment as an important component of neurorehabilitation: introducing the BEEhive - brain and enriched environment (BEE) lab (hive)

Disability and Rehabilitation, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Фев. 12, 2025

Contemporary healthcare design often overlooks the environment as a resource for supporting patient well-being and rehabilitation, particularly in neurotrauma care. The prioritisation of safety efficiency has created stressful spaces that negatively impact needs. This paper explores whether environmental enrichment can enhance rehabilitation outcomes individuals recovering from neurotrauma. It also introduces BEEhive laboratory, multidisciplinary initiative integrating principles into healthcare. reviews literature on role synthesising empirical evidence its benefits, highlighting potential to improve various aspects neurorehabilitation. findings are applied laboratory's objectives. Environmental is shown stimulate neurogenesis, increase engagement, reduce disruptive behaviours depressive symptoms, facilitate social relationships, cognitive functioning, stress, alleviate boredom. Despite these application remains underexplored. laboratory aims address this gap through collaboration, implementing strategies outcomes. To optimise outcomes, environments must holistically support well-being. Environmentally focused, sustainable interventions care, exemplified by initiative, crucial bridging between research practice, fostering innovative approaches rehabilitation.

Язык: Английский

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Suicidal risk is associated with hyper-connections in the frontal-parietal network in patients with depression

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 12, 2025

Suicide is a complex behavior strongly associated with depression. Despite extensive research, an objective biomarker for evaluating suicide risk precisely and timely still lacking. Using the precision resting-state fMRI method, we studied 61 depressive patients ideation (SI) or attempt (SA), 35 without SI to explore functional biomarkers of risk. Among them, 21 participants also completed electroconvulsive therapy (ECT) treatment, allowing examination changes across different states within same individual. Functional networks were localized in each subject using then individualized connectome was constructed represent subject's brain organization. We identified set connections that track (r = 0.41, p 0.001) found these risk-associated hyper-connected frontoparietal network (FPN, 0.008, Cohen's d 0.58) compared those without. Moreover, ECT treatment significantly reduced (p 0.001, 0.56) normalized FPN hyper-connections. These findings suggest involving may constitute important provide potential targets interventions such as non-invasive stimulation.

Язык: Английский

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Amygdala Allostasis and Early Life Adversity: Considering Excitotoxicity and Inescapability in the Sequelae of Stress

Frontiers in Human Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Июнь 1, 2021

Early life adversity (ELA), such as child maltreatment or poverty, engenders problems with emotional and behavioral regulation. In the quest to understand neurobiological sequelae mechanisms of risk, amygdala has been major focus. While basic functions this region make it a strong candidate for understanding multiple mental health issues common after ELA, extant literature is marked by profound inconsistencies, reports larger, smaller, no differences in regional volumes area. We believe integrative models stress neurodevelopment, grounded “ allostatic load ,” will help resolve inconsistencies impact ELA on amygdala. review, we attempt connect past research studies new findings animal cellular neurotransmitter mediators buffering extreme fear generalization onto testable clinical concepts. Drawing greater inescapability over unpredictability models, propose mechanism which aggravates an exhaustive cycle expansion subsequent toxic-metabolic damage. sequela psychosocial mal/adaptation bridging attachment, emotion processing, social functioning. Lastly, conclude review proposing multitude future directions preclinical work humans that suffered ELA.

Язык: Английский

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Childhood abuse influences clinical features of major depressive disorder by modulating the functional network of the right amygdala subregions

Asian Journal of Psychiatry, Год журнала: 2024, Номер 93, С. 103946 - 103946

Опубликована: Фев. 2, 2024

Язык: Английский

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Alterations in the white matter structure of major depressive disorder patients and their link to childhood trauma

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Март 4, 2024

Objectives Major Depressive Disorder (MDD) is significantly influenced by childhood trauma (CT), affecting brain anatomy and functionality. Despite the unique disease trajectory in MDD patients with CT, underlying neurobiological mechanisms remain unclear. Our objective to investigate CT’s impact on white matter structure of MDD. Methods This research employed tract-based spatial statistics (TBSS) detect variations between groups Fractional Anisotropy (FA) throughout whole 71 medication-free 97 HCs. Participants filled out Childhood Trauma Questionnaire (CTQ) assessments for depression anxiety symptoms. The relationship FA CTQ scores was explored partial correlation analysis, adjusting factors such as age, gender, educational background, length illness. Results Compared HCs, group showed decreased values right posterior limb internal capsule (PLIC), inferior fronto-occipital fasciculus (IFOF), bilateral superior longitudinal (SLF). Simple effects analysis revealed that compared HC-CT, MDD-CT demonstrated PLIC, IFOF, SLF. MDD-nCT PLIC IFOF HC-nCT. total subscale were negatively correlated Conclusion SLF may potentially be CT during development individuals These results enhance our knowledge role pathophysiology which influences

Язык: Английский

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The microbiota-gut-brain axis in pathogenesis of depression: A narrative review

Physiology & Behavior, Год журнала: 2022, Номер 260, С. 114056 - 114056

Опубликована: Дек. 14, 2022

Язык: Английский

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Childhood trauma and internalizing and externalizing behavior problems among adolescents: Role of executive function and life events stress

Journal of Adolescence, Год журнала: 2023, Номер 95(4), С. 740 - 750

Опубликована: Фев. 7, 2023

Язык: Английский

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Childhood adversity severity modulates the associations between adaptive psychological changes and amygdala volumetric changes in response to behavioral interventions

Journal of Affective Disorders Reports, Год журнала: 2023, Номер 15, С. 100714 - 100714

Опубликована: Дек. 30, 2023

Adverse Childhood Experience (ACE) has been shown to have detrimental impact on amygdala structure. Prior research found that adaptive psychological changes after Mindfulness-Based Interventions (MBI) were associated with volumetric changes. The present study aims further investigate whether such effects also occur among ACE survivors and the are unique MBI. A total of 64 young adult childhood adversity randomized an eight-week MBI or Stress Management Education (SME) as active control condition. Anatomical MRI questionnaires mindfulness, stress health collected at baseline post-intervention. Due subject dropout, final sample included 39 subjects (MBI:20, SME:19). Both groups showed increased mindfulness levels, reduced stress, improved symptoms (depression, anxiety, somatization), no significant group by time interaction effect. There was difference Within group, maltreatment severity a mediator between levels right Across pooled both groups, moderator for effect trait anxiety level left Modest size, relatively low retention rates, suboptimal monitoring home practice. did not demonstrate overall better clinical than SME. Psychological-change-dependent change specific modulated relationships

Язык: Английский

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