Whole grain benefit: synergistic effect of oat phenolic compounds and β-glucan on hyperlipidemiaviagut microbiota in high-fat-diet mice

Food & Function, Год журнала: 2022, Номер 13(24), С. 12686 - 12696

Опубликована: Янв. 1, 2022

Increasing evidence has confirmed that whole grain oats are effective in regulating hyperlipidemia. However, which specific ingredient is crucial remains unclear. This study focused on components, oat phenolic compounds (OPC) or β-glucan (OBG), can regulate lipid metabolism and gut microbiota. The experiment unveiled OPC and/or OBG not only reduced the body weight fasting blood glucose (FBG) but also regulated serum hepatic levels high-fat-diet (HFD) fed mice. There was no significant difference regulatory effects of (p > 0.05). combination (OPC + OBG) significantly decreased < 0.01) profile 0.01). real-time quantitative PCR (RT-qPCR) revealed altered mRNA expression related to metabolism. Histopathological analysis showed improved liver deposition as well oxidative stress In addition, microbiota community phenotype increased probiotics. abundance Bacteroidetes Firmicutes 0.05) compared with conclusion, a synergistic effect alleviating hyperlipidemia via composition. finding provided potential justification for advantages grains preventing

Язык: Английский

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Dendrobium as a new natural source of bioactive for the prevention and treatment of digestive tract diseases: A comprehensive review with future perspectives

Phytomedicine, Год журнала: 2023, Номер 114, С. 154784 - 154784

Опубликована: Март 22, 2023

Язык: Английский

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Biochemical Conversion of Passion Fruit Waste Into Highly Bioaccessible, Stable, and Selectively Functional Products

Waste and Biomass Valorization, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Язык: Английский

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A comprehensive review of the classification, sources, biosynthesis, and biological properties of hydroxybenzoic and hydroxycinnamic acids

Phytochemistry Reviews, Год журнала: 2023, Номер unknown

Опубликована: Сен. 17, 2023

Язык: Английский

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Wheat Bran Polyphenols Ameliorate DSS-Induced Ulcerative Colitis in Mice by Suppressing MAPK/NF-κB Inflammasome Pathways and Regulating Intestinal Microbiota

Foods, Год журнала: 2024, Номер 13(2), С. 225 - 225

Опубликована: Янв. 10, 2024

Wheat bran (WB) is the primary by-product of wheat processing and contains a high concentration bioactive substances such as polyphenols. This study analyzed qualitative quantitative components polyphenols in their effects on ulcerative colitis (UC) using dextran sulfate sodium (DSS)-induced model mice. The potential mechanism (WBP) was also examined. Our findings indicate that main polyphenol constituents WBP were phenolic acids, including vanillic acid, ferulic caffeic gallic protocatechuic acid. Furthermore, exerted remarkable protective against experimental colitis. achieved by reducing severity improving colon morphology. Additionally, suppressed colonic inflammation via upregulation anti-inflammatory cytokine IL-10 downregulation pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) tissues. Mechanistically, ameliorated DSS-induced mice inhibiting activation MAPK/NF-κB pathway. In addition, microbiome analysis results suggested modulated alteration gut microbiota caused DSS, with an enhancement ratio Firmicutes/Bacteroidetes adjustments number Helicobacter, Escherichia-Shigella, Akkermansia, Lactobacillus, Lachnospiraceae_NK4A136_group at genus level. To conclude, showed has excellent prospects UC

Язык: Английский

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Ultrasound-assisted glycosylation of ovalbumin and dextran conjugate carrier for anthocyanins and their stability evaluation

Ultrasonics Sonochemistry, Год журнала: 2024, Номер 109, С. 107024 - 107024

Опубликована: Авг. 10, 2024

Anthocyanins (AC) are vulnerable to degradation when affected by external factors. The present study employed ultrasound-assisted glycosylation of ovalbumin (OVA) and dextran (Dex) generate conjugate carrier for AC improve its stability. results showed that sonication significantly improved the progression Maillard reaction OVA. Compared traditional glycosylation, ultrasound treatment a higher degree grafting, lower number free-SH, smaller particle size uniform distribution. SDS-PAGE indicated covalent interaction. Intrinsic fluorescence (INF), Fourier transform infrared spectroscopy (FTIR), Circular dichroism (CD) analysis suggested altered OVA structure. scanning electron microscope (SEM) X-ray diffractometer (XRD) observed complex had more compact smoother structure protein unfolding were better. solubility increased after glycosylation. Thermal gravimetric (TGA) Differential calorimetry (DSC) glycosylated conjugates can thermal stability In addition, an processing storage conjugated with carrier. protein-anthocyanins may help provide new ideas scientific basis development naturally sourced anthocyanins-relevant products in pharmaceutical food industry applications.

Язык: Английский

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Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation

Ultrasonics Sonochemistry, Год журнала: 2022, Номер 92, С. 106242 - 106242

Опубликована: Ноя. 26, 2022

A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into composite with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties film. The optimized significantly increases elongation at break, tensile strength, improves film's UV/water/oxygen barrier properties. Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, good intermolecular compatibility. Besides, TP@Pul/Tre has proven have antibacterial performance against Escherichia coli Staphylococcus aureus, approximately 100 % lethality 4 h 8 h, respectively. Moreover, effectively delayed moisture loss, oxidative browning, decay, deterioration in fresh-cut apples pears, thereby extending their shelf life. Thus, ultrasound proved be an effective tool improving quality films, wide range applications.

Язык: Английский

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Therapeutic potential of cranberry for kidney health and diseases

eFood, Год журнала: 2022, Номер 3(5)

Опубликована: Сен. 20, 2022

Abstract A higher risk of cardiovascular mortality in persons with chronic renal failure (CRF) is linked to inflammation, oxidative stress, cellular aging, and gut dysbiosis, name a few contributing factors. According growing body evidence, some dietary choices may reduce the severity certain adverse effects. Specialized databases such as PubMed/Medline, Embase, Google Scholar, UpToDate were searched find published studies that focus on pharmacological effects mechanisms cranberries’ bioactive compounds CRF human health. Cranberry supplementation has been demonstrated clinical research offer health advantages for humans, reducing urinary tract infections. Recently, it reported cranberry polyphenols possess anti‐inflammatory antioxidant are also known have capacity affect flora. Scientific beneficial cranberries provide an understanding traditional therapy kidney disease other conditions. However, translational needed determine exact dose can be administered humans well validation nutritional supplements contain extract.

Язык: Английский

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Health-Promoting Properties and Potential Application in the Food Industry of Citrus medica L. and Citrus × clementina Hort. Ex Tan. Essential Oils and Their Main Constituents

Plants, Год журнала: 2023, Номер 12(5), С. 991 - 991

Опубликована: Фев. 21, 2023

is an important genus in the Rutaceae family, with high medicinal and economic value, includes crops such as lemons, orange, grapefruits, limes, etc. The

Язык: Английский

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Prospects for the application of traditional Chinese medicine network pharmacology in food science research

Journal of the Science of Food and Agriculture, Год журнала: 2023, Номер 103(11), С. 5183 - 5200

Опубликована: Март 8, 2023

There has always been a particular difficulty with in-depth research on the mechanisms of food nutrition and bioactivity. The main function is to meet nutritional needs human body, rather than exert therapeutic effect. Its relatively modest biological activity makes it difficult study from perspective general pharmacological models. With popularity functional foods concept dietary therapy, development information multi-omics technology in research, into these moving towards more microscopic future. Network pharmacology accumulated nearly 20 years experience traditional Chinese medicine (TCM), there no shortage work this medicinal functions food. Given similarity between 'multi-component-multi-target' properties TCM, we think that network applicable complex Here review pharmacology, summarize its application 'medicine homology', propose methodology based characteristics for first time, demonstrating feasibility research. © 2023 Society Chemical Industry.

Язык: Английский

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