Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

ChemSusChem, Год журнала: 2021, Номер 14(10), С. 2145 - 2162

Опубликована: Апрель 9, 2021

In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. addition to their efficiency and practicality, mechanochemical reactions are also recognized sustainability. The association between Green Chemistry often originates from the solvent-free nature of most protocols, which can reduce waste production. However, satisfies more than one Principles Chemistry. this Review we will present series examples that clearly illustrate how significantly contribute fulfillment in holistic manner.

Язык: Английский

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Outstanding Advantages, Current Drawbacks, and Significant Recent Developments in Mechanochemistry: A Perspective View

Crystals, Год журнала: 2023, Номер 13(1), С. 124 - 124

Опубликована: Янв. 10, 2023

Although known since antiquity, mechanochemistry has remained dormant for centuries. Nowadays, is a flourishing research field at the simultaneous stages of gathering data and (often astonishing) observations, scientific argumentation toward their analysis, which combination interdisciplinary expertise necessary. Mechanochemistry’s implementation as synthetic method constantly increasing, although it remains far from being fully exploited, or understood on basis fundamental principles. This review starts by describing many remarkable advantages mechanochemical reactions, simplifying “greening” chemistry in solutions. description followed an overview current main weaknesses to be addressed near future systematic study its energetics chemical mechanisms. finishes recent breakthrough experimental advances, such situ kinetics monitoring using synchrotron X-ray powder diffraction Raman spectroscopy, plus equally significant computational approaches, quantum mechanochemistry, used understanding covalent hydrogen bond ruptures biomolecules mechanophores polymers single-molecule level. Combined with new technologies control temperature pressure ball mills, these appealing methods are promising tools establishing knowledge necessary reactivity

Язык: Английский

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Copper-Catalyzed Construction of Benzo[4,5]imidazo[2,1-a]isoquinolines Using Calcium Carbide as a Solid Alkyne Source

Organic Letters, Год журнала: 2021, Номер 23(21), С. 8407 - 8412

Опубликована: Окт. 11, 2021

A method for the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines through Sonogashira cross-coupling/nucleophilic addition tandem reactions using calcium carbide as a solid alkyne source, 2-(2-bromophenyl)benzimidazoles starting materials, and copper catalyst is described. The target products can also be synthesized one-pot three-component o-phenylenediamines, o-bromobenzaldehydes, carbide. Both reaction routes scaled up to gram scale.

Язык: Английский

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Copper-catalyzed direct synthesis of 3-methylene-2-arylisoindolin-1-ones with calcium carbide as a surrogate of gaseous acetylene

Green Chemistry, Год журнала: 2023, Номер 25(9), С. 3425 - 3430

Опубликована: Янв. 1, 2023

A novel strategy for the synthesis of 3-methyleneisoindolin-1-ones through Sonogashira reactions using calcium carbide was reported. This is a green and sustainable development method.

Язык: Английский

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One-Pot Synthesis of 1,2,3-Triarylindoles through Cascade Reactions Using Calcium Carbide, Iodoarenes, and Aromatic Amines

Organic Letters, Год журнала: 2023, Номер 25(31), С. 5812 - 5816

Опубликована: Июль 31, 2023

An efficient method for the construction of 1,2,3-triarylindoles through one-pot multicomponent reactions using calcium carbide, 3 mol iodoarenes, and aromatic amines as starting materials was described. A series target products were obtained by simultaneous formation five bonds in one step. The main advantages this protocol are use a convenient alkyne source, wide scope substrates, simple workup procedure. can be extended to gram scale.

Язык: Английский

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Calcium carbide: Highly potent solid reagent for the construction of heterocycles

Tetrahedron, Год журнала: 2023, Номер 149, С. 133720 - 133720

Опубликована: Ноя. 1, 2023

Язык: Английский

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Three-Component One-Pot Construction of 2-Aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines Using Solid Calcium Carbide as a Surrogate of Gaseous Acetylene

Organic Letters, Год журнала: 2022, Номер 24(29), С. 5491 - 5496

Опубликована: Июль 17, 2022

A concise method for the construction of 2-aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines using solid calcium carbide instead gaseous acetylene as an alkyne source and 2-aminobenzothiazoles aromatic aldehydes substrates through one-pot three-component cascade reactions is described. The salient features this protocol are use inexpensive easy-to-handle source, noble-metal-free condition, wide substrate scope functional tolerance, satisfactory yield, simple workup procedure.

Язык: Английский

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Switchable Synthesis of 2-Methylene-3-aminoindolines and 2-Methyl-3-aminoindoles Using Calcium Carbide as a Solid Alkyne Source

Organic Letters, Год журнала: 2022, Номер 24(43), С. 8067 - 8071

Опубликована: Окт. 26, 2022

The one-pot three-component method for the switchable synthesis of 2-methylene-3-aminoindolines and 2-methyl-3-aminoindoles by reactions N-(2-formylaryl)sulfonamides, secondary amines, calcium carbide is described. This protocol has salient features use an inexpensive, abundant, easy-to-handle solid alkyne source, avoiding flammable explosive gaseous acetylene as original source. In addition, a wide scope substrates, satisfactory yield, simple workup procedure are also advantages this method.

Язык: Английский

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Metal-catalyzed chemical activation of calcium carbide: New way to hierarchical metal/alloy-on-carbon catalysts

Journal of Catalysis, Год журнала: 2022, Номер 407, С. 281 - 289

Опубликована: Фев. 4, 2022

Язык: Английский

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Atom-economical synthesis of 1,2-bis(phosphine oxide)ethanes from calcium carbide with straightforward access to deuterium- and¹³C-labeled bidentate phosphorus ligands and metal complexes

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(4), С. 1022 - 1033

Опубликована: Янв. 1, 2023

Straightforward access to bidentate phosphorus ligands and bis(phosphineoxide)ethanes is described based on atom-economic addition reaction. A practical approach was developed incorporate 2 H 13 C labels using easily available reagents.

Язык: Английский

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