Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

ChemSusChem, Journal Year: 2021, Volume and Issue: 14(10), P. 2145 - 2162

Published: April 9, 2021

In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. addition to their efficiency and practicality, mechanochemical reactions are also recognized sustainability. The association between Green Chemistry often originates from the solvent-free nature of most protocols, which can reduce waste production. However, satisfies more than one Principles Chemistry. this Review we will present series examples that clearly illustrate how significantly contribute fulfillment in holistic manner.

Language: Английский

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Outstanding Advantages, Current Drawbacks, and Significant Recent Developments in Mechanochemistry: A Perspective View

Crystals, Journal Year: 2023, Volume and Issue: 13(1), P. 124 - 124

Published: Jan. 10, 2023

Although known since antiquity, mechanochemistry has remained dormant for centuries. Nowadays, is a flourishing research field at the simultaneous stages of gathering data and (often astonishing) observations, scientific argumentation toward their analysis, which combination interdisciplinary expertise necessary. Mechanochemistry’s implementation as synthetic method constantly increasing, although it remains far from being fully exploited, or understood on basis fundamental principles. This review starts by describing many remarkable advantages mechanochemical reactions, simplifying “greening” chemistry in solutions. description followed an overview current main weaknesses to be addressed near future systematic study its energetics chemical mechanisms. finishes recent breakthrough experimental advances, such situ kinetics monitoring using synchrotron X-ray powder diffraction Raman spectroscopy, plus equally significant computational approaches, quantum mechanochemistry, used understanding covalent hydrogen bond ruptures biomolecules mechanophores polymers single-molecule level. Combined with new technologies control temperature pressure ball mills, these appealing methods are promising tools establishing knowledge necessary reactivity

Language: Английский

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Copper-Catalyzed Construction of Benzo[4,5]imidazo[2,1-a]isoquinolines Using Calcium Carbide as a Solid Alkyne Source

Organic Letters, Journal Year: 2021, Volume and Issue: 23(21), P. 8407 - 8412

Published: Oct. 11, 2021

A method for the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines through Sonogashira cross-coupling/nucleophilic addition tandem reactions using calcium carbide as a solid alkyne source, 2-(2-bromophenyl)benzimidazoles starting materials, and copper catalyst is described. The target products can also be synthesized one-pot three-component o-phenylenediamines, o-bromobenzaldehydes, carbide. Both reaction routes scaled up to gram scale.

Language: Английский

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Copper-catalyzed direct synthesis of 3-methylene-2-arylisoindolin-1-ones with calcium carbide as a surrogate of gaseous acetylene

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(9), P. 3425 - 3430

Published: Jan. 1, 2023

A novel strategy for the synthesis of 3-methyleneisoindolin-1-ones through Sonogashira reactions using calcium carbide was reported. This is a green and sustainable development method.

Language: Английский

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One-Pot Synthesis of 1,2,3-Triarylindoles through Cascade Reactions Using Calcium Carbide, Iodoarenes, and Aromatic Amines

Organic Letters, Journal Year: 2023, Volume and Issue: 25(31), P. 5812 - 5816

Published: July 31, 2023

An efficient method for the construction of 1,2,3-triarylindoles through one-pot multicomponent reactions using calcium carbide, 3 mol iodoarenes, and aromatic amines as starting materials was described. A series target products were obtained by simultaneous formation five bonds in one step. The main advantages this protocol are use a convenient alkyne source, wide scope substrates, simple workup procedure. can be extended to gram scale.

Language: Английский

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Calcium carbide: Highly potent solid reagent for the construction of heterocycles

Tetrahedron, Journal Year: 2023, Volume and Issue: 149, P. 133720 - 133720

Published: Nov. 1, 2023

Language: Английский

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Three-Component One-Pot Construction of 2-Aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines Using Solid Calcium Carbide as a Surrogate of Gaseous Acetylene

Organic Letters, Journal Year: 2022, Volume and Issue: 24(29), P. 5491 - 5496

Published: July 17, 2022

A concise method for the construction of 2-aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines using solid calcium carbide instead gaseous acetylene as an alkyne source and 2-aminobenzothiazoles aromatic aldehydes substrates through one-pot three-component cascade reactions is described. The salient features this protocol are use inexpensive easy-to-handle source, noble-metal-free condition, wide substrate scope functional tolerance, satisfactory yield, simple workup procedure.

Language: Английский

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Switchable Synthesis of 2-Methylene-3-aminoindolines and 2-Methyl-3-aminoindoles Using Calcium Carbide as a Solid Alkyne Source

Organic Letters, Journal Year: 2022, Volume and Issue: 24(43), P. 8067 - 8071

Published: Oct. 26, 2022

The one-pot three-component method for the switchable synthesis of 2-methylene-3-aminoindolines and 2-methyl-3-aminoindoles by reactions N-(2-formylaryl)sulfonamides, secondary amines, calcium carbide is described. This protocol has salient features use an inexpensive, abundant, easy-to-handle solid alkyne source, avoiding flammable explosive gaseous acetylene as original source. In addition, a wide scope substrates, satisfactory yield, simple workup procedure are also advantages this method.

Language: Английский

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Metal-catalyzed chemical activation of calcium carbide: New way to hierarchical metal/alloy-on-carbon catalysts

Journal of Catalysis, Journal Year: 2022, Volume and Issue: 407, P. 281 - 289

Published: Feb. 4, 2022

Language: Английский

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Atom-economical synthesis of 1,2-bis(phosphine oxide)ethanes from calcium carbide with straightforward access to deuterium- and¹³C-labeled bidentate phosphorus ligands and metal complexes

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(4), P. 1022 - 1033

Published: Jan. 1, 2023

Straightforward access to bidentate phosphorus ligands and bis(phosphineoxide)ethanes is described based on atom-economic addition reaction. A practical approach was developed incorporate 2 H 13 C labels using easily available reagents.

Language: Английский

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