Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(16), С. 2815 - 2821
Опубликована: Июль 11, 2022
Abstract
The
α‐alkylation
of
ketones
utilizing
a
secondary
alcohol
has
been
accomplished
by
an
isolable,
bench‐stable,
inexpensive
nickel
catalyst
affording
high
yields
β,β‐disubstituted
products.
This
report
contributes
in
the
pool
few
scarce
examples
base
metal
discovered
for
this
purpose.
substrate
scope
can
span
wide
range
including
aliphatic,
alicyclic,
and
cyclic
alcohols.
Functionalization
cholesterol
molecule
is
also
possible
following
methodology.
interconvert
between
azo
hydrazo
form
reversible
fashion
to
enable
chemical
transformation.
magnified
image
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(39), С. 7713 - 7745
Опубликована: Янв. 1, 2022
Recent
advances
in
C/N
alkylation
using
alcohols
as
alkylating
reagents
via
hydrogen-shuttle
methodologies:
Borrowing
Hydrogen,
Acceptorless
Dehydrogenative
Coupling,
and
Base-mediated
Hydride
Transfer.
Organometallics,
Год журнала:
2023,
Номер
42(14), С. 1803 - 1809
Опубликована: Апрель 11, 2023
A
new
family
of
air-stable
Mn
and
Re
complexes
bearing
bidentate
bis(1,2,3-triazol-5-ylidene)
ligands
with
the
general
formula
[M(bis-triazolylidene)(CO)3X]
(M
=
or
Re;
X
Cl
Br),
containing
a
methylene
linker
direct
link
between
two
triazolylidene
ligands,
is
presented.
All
have
been
applied
as
catalysts
for
N-alkylation
anilines
benzylic
alcohols.
The
complex
bis-triazolylidene
bridge
fragments
was
shown
to
be
highly
efficient
catalyst,
affording
corresponding
amine
in
92%
yield
presence
low
base
loading
(t-BuOK,
0.1
equiv).
Comparison
imidazolium-
triazolium-derived
N-heterocyclic
carbene
showed
that
triazolylidenes
displayed
higher
catalytic
activity
when
used.
The
application
of
enzymes
in
synthetic
organic
chemistry
has
emerged
as
a
powerful
means
to
generate
molecular
complexity
highly
selective,
efficient,
and
sustainable
manner.
While
have
increasingly
been
incorporated
into
sequences
for
numerous
academic
industrial
applications
on
their
own
sequential
processes,
utility
cooperative
catalysis
with
small
molecule
catalytic
platforms
recently
drawn
increased
attention
across
the
field
synthesis.
In
this
review,
we
present
selection
notable
accomplishments
chemoenzymatic
provide
perspective
its
future
directions.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2142 - 2164
Опубликована: Янв. 17, 2024
Abstract
N‐Heterocyclic
compounds,
in
particular,
quinolines
and
quinazolines
are
frequently
used
medicinal
chemistry.
Therefore,
the
direct
clean
synthesis
of
these
valuable
scaffolds
has
been
a
great
interest
for
many
years.
2‐Aminobenzyl
alcohols
as
an
alternative
reactant
instead
unstable
expensive
2‐aminobenzaldehydes
can
be
construction
N‐fused
heterocycles
including
quinolines,
quinazolines,
oxazines,
thiazines,
selenazines,
imidazoles,
diazepines,
etc.
In
this
review
article,
we
have
discussed
recent
developments
use
2‐aminobenzyl
diverse
heterocycles.
Catalysis Science & Technology,
Год журнала:
2022,
Номер
12(10), С. 3202 - 3208
Опубликована: Янв. 1, 2022
The
synthesis
of
N-heterocycles
has
been
considered
an
emerging
topic
chemical
research
due
to
its
widespread
usage
in
medicinal
chemistry,
materials
science,
and
natural
product
synthesis.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(9), С. 1945 - 1951
Опубликована: Янв. 1, 2022
Ru
II
-Complexes
of
a
heteroditopic
NHC
ligand,
featuring
ImNHC
and
tzNHC
donors,
were
noted
to
be
very
efficient
catalysts
(up
0.001
mol%)
for
β-alkylation
secondary
alcohols
one
pot
synthesis
diverse
2-alkylaminoquinoline
derivatives.
Abstract
Green
chemistry
is
the
basis
for
fast‐growing,
eco‐friendly,
alternative
sustainable
technologies
development
of
chemical
products
without
use
or
generation
hazardous
catalysts.
The
role
naturally
occurring
fruit
juice
as
a
catalyst
solvent
in
organic
synthesis
has
gained
focused
interest
across
globe.
Lemon
juice‐mediated
been
widely
explored
recently
highly
significant,
selective
and
biocatalyst
synthesis.
This
review
presents
recent
developments
on
lemon‐juice
mediated
transformations
their
application
to
synthesize
molecules
building
blocks
pharmaceutical
interest.
We
believe
this
article
will
be
researchers
both
academic
industrial
settings
developing
novel
pharmacophores
from
green
principles
perspective.
