Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(13), С. 2620 - 2629
Опубликована: Янв. 1, 2024
Mechanochemical
reactions
achieved
by
processes
such
as
milling
and
grinding
are
promising
alternatives
to
traditional
solution-based
chemistry.
This
approach
not
only
eliminates
the
need
for
large
amounts
of
solvents,
thereby
reducing
waste
generation,
but
also
finds
applications
in
chemical
materials
synthesis.
The
focus
this
study
is
on
synthesis
quinazolinone
derivatives
ball
milling,
particular
evodiamine
rutaecarpine
analogues.
These
compounds
interest
due
their
diverse
bioactivities,
including
potential
anticancer
properties.
examines
carried
out
under
conditions,
emphasizing
efficiency
terms
shorter
reaction
times
reduced
environmental
impact
compared
conventional
methods.
analogues
resulted
yields
63-78%
22-61%,
respectively.
In
addition,
these
were
tested
cytotoxic
activity,
exhibited
an
IC
RSC Mechanochemistry,
Год журнала:
2024,
Номер
1(2), С. 189 - 195
Опубликована: Янв. 1, 2024
The
mechanochemical
protecting-group-free
amidation
of
hydroxycarboxylic
acids
is
presented.
transformation
applied
to
the
synthesis
imatinib
via
a
two-fold
C–N
bond
construction
sequence
that
bypasses
chlorinated
genotoxic
intermediate.
Green Chemistry,
Год журнала:
2024,
Номер
26(14), С. 8341 - 8347
Опубликована: Янв. 1, 2024
Resonant
Acoustic
Mixing
(RAM)
allows
High
Throughput
Experimentation
(HTE)
using
commercially
available
96-well
plates
as
exemplified
by
the
nickel
catalyzed
C–N
cross
coupling
of
aryl
halides
with
different
amine
and
anilines.
Organic Letters,
Год журнала:
2022,
Номер
24(12), С. 2338 - 2343
Опубликована: Март 17, 2022
The
direct
synthesis
of
ketones
via
acyl
Suzuki-Miyaura
cross-coupling
widely
available
chlorides
is
a
central
transformation
in
organic
synthesis.
Herein,
we
report
the
first
mechanochemical
solvent-free
method
for
highly
chemoselective
from
and
boronic
acids.
This
acylation
reaction
conducted
solid
state,
absence
potentially
harmful
solvents,
short
time
shows
excellent
selectivity
C(acyl)-Cl
bond
cleavage.
Green Chemistry,
Год журнала:
2022,
Номер
24(11), С. 4557 - 4565
Опубликована: Янв. 1, 2022
The
need
for
an
operationally
straightforward
application
of
radical
chemistry
has
led
researchers
to
explore
practical
strategies
obtain
and
trap
radicals.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2023,
Номер
11(45), С. 16156 - 16164
Опубликована: Окт. 27, 2023
A
solid-state
approach
was
used
to
synthesize
compound
PZ-1190,
a
multitarget
ligand
for
serotonin
and
dopamine
receptors
with
potential
antipsychotic
activity
in
rodents.
Compared
the
classical
batch
synthesis
approach,
developed
multistep
mechanochemical
protocol
improved
overall
yield
(from
32%
56%),
reduced
reaction
time
42
4
h),
decreased
use
of
toxic
reagents
organic
solvents.
All
synthesized
intermediates
PZ-1190
were
isolated
high
purity
by
extraction
without
requirement
chromatographic
purification.
obtained
enantiomeric
(≥99%
ee)
no
impact
grinding
processes
on
integrity
stereocenter.
The
described
procedures
represent
rare
examples
reduction
carboxylic
function,
which
might
open
up
possibility
obtaining
crucial
β-
γ-amino
alcohols
sustainable
manner.
oxidation
an
aliphatic
alcohol
into
aldehyde
using
mechanochemistry
has
also
been
reported
first
time.
results
confirmed
suitability
as
efficient
method
synthesizing
candidates
preclinical
development.
Green Chemistry,
Год журнала:
2024,
Номер
26(8), С. 4871 - 4879
Опубликована: Янв. 1, 2024
Aiming
at
the
development
of
low-impact
synthetic
pathways,
we
herein
report
simultaneous
employment
different
tools
to
improve
overall
sustainability
Suzuki–Miyaura
(SM)
cross-coupling
with
a
circular
economy
approach.
Molecules,
Год журнала:
2025,
Номер
30(2), С. 236 - 236
Опубликована: Янв. 9, 2025
Orthopalladated
derivatives
from
substituted
phenylglycines
[Pd(μ-Cl)(C6H3R1C(R2)(R3)N(R4)2]2
(1)
react
with
halogenating
reagents
(PhICl2,
Br2,
I2)
(2)
to
give
the
corresponding
o-halogenated
amino
acids
C6H3(X)R1C(R2)(R3)N(R4)2
(3).
The
reaction
is
general
and
tolerates
a
variety
of
functional
groups
(R1
R4)
at
aryl
ring,
Cα,
N
atom.
On
other
hand,
PhI(OAc)2
in
presence
alcohols
R5OH
(4)
gives
o-alkoxylated
C6H3(OR5)R1C(R2)(R3)N(R4)2
(5),
also
as
process.
A
partial
loss
enantiomeric
excess
observed
when
starting
phenylglycine
enantiomerically
pure,
this
arising
formation
bridging
azavinylidene
(6)
imine
intermediate
species
(7),
which
were
characterized
by
X-ray
diffraction
methods.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
23(19), С. 4636 - 4640
Опубликована: Янв. 1, 2025
The
solvent-free
mechanochemical
method
enables
efficient
synthesis
of
diverse
organothianthrenium
salts
via
ball-milling
technique,
eliminating
the
need
for
hazardous
reactants,
inert
atmosphere,
and
complex
reaction
setups.
