Chemistry - Methods,
Journal Year:
2022,
Volume and Issue:
2(12)
Published: July 12, 2022
Abstract
Catalyzed
reactions
of
organic
substrates
that
operate
continuously
by
extrusion
techniques
are
rare.
In
this
study,
we
developed
a
mechanochemical
bromination
unactivated
naphthalene
(
1
)
with
1,3‐dibromo‐5,5‐dimethylhydantoin
DBDMH
),
catalyzed
zeolites
in
ball
mill.
The
use
enabled
the
atom
economy
reaction
to
be
superior
compared
other
brominating
agents
evaluated.
Among
tested,
FAU‐type
zeolite
demonstrated
high
catalytic
activity
and
recyclability.
success
route
on
small
scale
development
continuous
twin‐screw
extrusion.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(8), P. 4871 - 4879
Published: Jan. 1, 2024
Aiming
at
the
development
of
low-impact
synthetic
pathways,
we
herein
report
simultaneous
employment
different
tools
to
improve
overall
sustainability
Suzuki–Miyaura
(SM)
cross-coupling
with
a
circular
economy
approach.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(14), P. 8341 - 8347
Published: Jan. 1, 2024
Resonant
Acoustic
Mixing
(RAM)
allows
High
Throughput
Experimentation
(HTE)
using
commercially
available
96-well
plates
as
exemplified
by
the
nickel
catalyzed
C–N
cross
coupling
of
aryl
halides
with
different
amine
and
anilines.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(12), P. 2338 - 2343
Published: March 17, 2022
The
direct
synthesis
of
ketones
via
acyl
Suzuki-Miyaura
cross-coupling
widely
available
chlorides
is
a
central
transformation
in
organic
synthesis.
Herein,
we
report
the
first
mechanochemical
solvent-free
method
for
highly
chemoselective
from
and
boronic
acids.
This
acylation
reaction
conducted
solid
state,
absence
potentially
harmful
solvents,
short
time
shows
excellent
selectivity
C(acyl)-Cl
bond
cleavage.
Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(11), P. 4557 - 4565
Published: Jan. 1, 2022
The
need
for
an
operationally
straightforward
application
of
radical
chemistry
has
led
researchers
to
explore
practical
strategies
obtain
and
trap
radicals.
Organic Process Research & Development,
Journal Year:
2023,
Volume and Issue:
27(2), P. 269 - 275
Published: Feb. 3, 2023
Chemical
reactions
that
take
place
in
a
ball
mill
and
the
absence
of
bulk
reaction
solvent
present
different
safety
profiles
to
stirred
solution
reactions.
Herein,
we
describe
steps
researcher
may
better
ensure
they
have
considered
some
hazards
measures
emerge
minimize
risk
themselves
their
colleagues.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2023,
Volume and Issue:
11(45), P. 16156 - 16164
Published: Oct. 27, 2023
A
solid-state
approach
was
used
to
synthesize
compound
PZ-1190,
a
multitarget
ligand
for
serotonin
and
dopamine
receptors
with
potential
antipsychotic
activity
in
rodents.
Compared
the
classical
batch
synthesis
approach,
developed
multistep
mechanochemical
protocol
improved
overall
yield
(from
32%
56%),
reduced
reaction
time
42
4
h),
decreased
use
of
toxic
reagents
organic
solvents.
All
synthesized
intermediates
PZ-1190
were
isolated
high
purity
by
extraction
without
requirement
chromatographic
purification.
obtained
enantiomeric
(≥99%
ee)
no
impact
grinding
processes
on
integrity
stereocenter.
The
described
procedures
represent
rare
examples
reduction
carboxylic
function,
which
might
open
up
possibility
obtaining
crucial
β-
γ-amino
alcohols
sustainable
manner.
oxidation
an
aliphatic
alcohol
into
aldehyde
using
mechanochemistry
has
also
been
reported
first
time.
results
confirmed
suitability
as
efficient
method
synthesizing
candidates
preclinical
development.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 236 - 236
Published: Jan. 9, 2025
Orthopalladated
derivatives
from
substituted
phenylglycines
[Pd(μ-Cl)(C6H3R1C(R2)(R3)N(R4)2]2
(1)
react
with
halogenating
reagents
(PhICl2,
Br2,
I2)
(2)
to
give
the
corresponding
o-halogenated
amino
acids
C6H3(X)R1C(R2)(R3)N(R4)2
(3).
The
reaction
is
general
and
tolerates
a
variety
of
functional
groups
(R1
R4)
at
aryl
ring,
Cα,
N
atom.
On
other
hand,
PhI(OAc)2
in
presence
alcohols
R5OH
(4)
gives
o-alkoxylated
C6H3(OR5)R1C(R2)(R3)N(R4)2
(5),
also
as
process.
A
partial
loss
enantiomeric
excess
observed
when
starting
phenylglycine
enantiomerically
pure,
this
arising
formation
bridging
azavinylidene
(6)
imine
intermediate
species
(7),
which
were
characterized
by
X-ray
diffraction
methods.
