H₂O₂ Self‐Producing Single‐Atom Nanozyme Hydrogels as Light‐Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming “Cold” Tumors

Advanced Functional Materials, Год журнала: 2022, Номер 32(16)

Опубликована: Янв. 4, 2022

Abstract Single‐atom nanozyme (SAzyme) with peroxidase‐like activity can alter cellular redox balance and shows promising potential for tumor therapy. However, the “cold” immune microenvironment limited amount of hydrogen peroxide (H 2 O ) in solid tumors severely restrict its efficacy. Herein, a light‐controlled oxidative stress amplifier system is designed by co‐encapsulating Pd‐C SAzymes camptothecin agarose hydrogel, which exhibits enhanced synergistic antitumor self‐producing H transforming tumors. In this hydrogel system, SAzyme converts near‐infrared laser into heat, resulting degradation consequent release. The increases level activating nicotinamide adenine dinucleotide phosphate oxidase, improving catalytic performance activity. Moreover, combination photothermal therapy, chemotherapy, nanozyme‐based therapy further facilitates immunogenic death immunity. results reveal novel SAzyme/chemotherapeutics‐based system.

Язык: Английский

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Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication

Coordination Chemistry Reviews, Год журнала: 2022, Номер 475, С. 214896 - 214896

Опубликована: Окт. 27, 2022

Язык: Английский

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Carbon dots supported single Fe atom nanozyme for drug-resistant glioblastoma therapy by activating autophagy-lysosome pathway

Nano Today, Год журнала: 2022, Номер 45, С. 101530 - 101530

Опубликована: Июнь 22, 2022

Язык: Английский

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Nanozyme Catalytic Turnover and Self-Limited Reactions

ACS Nano, Год журнала: 2021, Номер 15(10), С. 15645 - 15655

Опубликована: Окт. 8, 2021

Enzymes have catalytic turnovers. The field of nanozyme endeavors to engineer nanomaterials as enzyme mimics. However, a discrepancy in the definition "nanozyme concentration" has led an unrealistic calculation To date, most reported works considered either atomic concentration or nanoparticle (NP) concentration. These assumptions can lead significant under- overestimation activity nanozymes. In this article, we review some classic nanozymes including Fe3O4, CeO2, and gold nanoparticles (AuNPs) with focus on activities. We argue that only surface atoms should be active sites, then turnover numbers rates were recalculated based atoms. According calculations, peroxidase Fe3O4 NPs is validated. AuNPs are self-limited when performing glucose-oxidase like activity, but they also true catalysts. For CeO2 NPs, behavior observed for both oxidase- phosphatase-like activities due adsorption reaction products. Moreover, single-atom discussed. Finally, few suggestions future research proposed.

Язык: Английский

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Exploration of nanozymes in viral diagnosis and therapy

Exploration, Год журнала: 2022, Номер 2(1)

Опубликована: Янв. 25, 2022

Abstract Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, synthesis of nanozymes their mechanisms advanced beyond simple replacement allowing fascinating applications in various fields such as biosensing disease treatment. particular, exploration powerful toolkits diagnostic viral testing antiviral therapy has attracted growing attention. It can address great challenges faced by current enzyme‐based technologies, high cost storage difficulties. Therefore, nanozyme provide a novel nanozyme‐based therapeutic regime broader availability generalizability that keys fighting pandemic COVID‐19. Herein, we timely review state‐of‐the‐art regarding activities, well focused discussion on recent research into use therapy. The remaining future perspectives will also be outlined. Ultimately, this inform readers knowledge inspire more innovative studies push forward frontier field.

Язык: Английский

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Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects

Med, Год журнала: 2022, Номер 4(3), С. 147 - 167

Опубликована: Дек. 21, 2022

Язык: Английский

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Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria‐Killing

Advanced Functional Materials, Год журнала: 2022, Номер 32(20)

Опубликована: Фев. 9, 2022

Abstract Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal effects, resulting dramatically increased peroxidase‐like activity when exposed 808 nm light. Both experimental results theoretical calculations show that remarkable catalytic performance CuS@GDY due unique hierarchical structure, narrow bandgap GDY nanowalls, effect CuS nanocages, fast interfacial electron transfer dynamics, carbon vacancies CuS@GDY. plasmonic exhibits rapid, efficient, broad‐spectrum antibacterial ( > 99.999%) against diverse pathogens (methicillin‐resistant Staphylococcus aureus , Escherichia coli ). study not only sheds light mechanism nanozyme‐/photocatalysis coupling process, also opens up new avenue for engineering NIR driven nanozymes rapid synergistic photo‐enhanced therapy.

Язык: Английский

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Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Апрель 22, 2023

Nanozymes have great potential to be used as an alternative natural enzymes in a variety of fields. However, low catalytic activity compared with limits their practical use. It is still challenging design nanozymes comparable counterparts terms the specific activity. In this study, surface engineering strategy employed improve Ru using charge-transferrable ligands such polystyrene sulfonate (PSS). PSS-modified nanozyme exhibits peroxidase-like up 2820 U mg

Язык: Английский

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Nanozyme-based pollutant sensing and environmental treatment: Trends, challenges, and perspectives

The Science of The Total Environment, Год журнала: 2022, Номер 854, С. 158771 - 158771

Опубликована: Сен. 13, 2022

Язык: Английский

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Living Macrophage-Delivered Tetrapod PdH Nanoenzyme for Targeted Atherosclerosis Management by ROS Scavenging, Hydrogen Anti-inflammation, and Autophagy Activation

ACS Nano, Год журнала: 2022, Номер 16(10), С. 15959 - 15976

Опубликована: Окт. 11, 2022

Atherosclerosis, driven by chronic inflammation in the artery walls, underlies several severe cardiovascular diseases. However, currently available anti-inflammatory-based strategies for atherosclerosis treatment suffer from compromised therapeutic efficacy and undesirable outcome. Herein, a distinct tetrapod needle-like PdH nanozyme was designed engineered efficient combinatorial reactive oxygen species (ROS) scavenging, hydrogen anti-inflammation, autophagy activation. After loading into macrophages targeted delivery to arterial plaques, these multifunctional nanozymes efficiently decreased ROS levels significantly suppressed inflammation-related pathological process, exerting antioxidation anti-inflammatory performance alleviating development. Especially importantly, specific spiky morphology of nanoenzyme further triggered strong response macrophages, synergistically maintaining cellular homeostasis Both vitro vivo results confirmed synergy among antioxidation, anti-inflammatory, activation, suggesting that engineering nanomedicines with intrinsic multiple functions topology-induced biological effects is highly preferable effective achieving high desirable outcome on management therapy.

Язык: Английский

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