Advanced Functional Materials,
Год журнала:
2023,
Номер
34(2)
Опубликована: Сен. 12, 2023
Abstract
Neurological
function
recovery
after
peripheral
nerve
injury
(PNI)
is
exceptionally
challenging,
chiefly
because
neurons
cannot
efficiently
proliferate,
differentiate,
and
form
regenerated
axons
to
pass
through
the
defect
region
expeditiously
transmit
neurological
signals.
In
this
study,
a
four‐dimensional
(4D)
oriented
dynamic
scaffold
constructed
based
on
shape
memory
polymer
(SMP),
which
can
regulate
spatiotemporally
controllable
neuronal
early
adequate
proliferation,
subsequently
effective
differentiation
axon
formation
by
synergizing
on‐demand
microtopography
deformation
force‐based
mechanical
stimuli
(DFMS).
This
accelerate
restoration
of
large
segmental
defects,
elevate
neural
signaling
efficiency
60%
compared
with
static
scaffold,
finally
functionalized
robust
regenerating
fascicles
comparable
therapeutic
effects
autologous
transplantation.
Furthermore,
crucial
role
Piezo1/Camk2b
modulated
extension
also
revealed
deep
transcriptomic
analysis.
summary,
4D
precisely
remotely
behavior
fate
in
non‐invasive
way,
has
excellent
potential
for
clinical
application
restoration.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(2)
Опубликована: Сен. 12, 2023
Abstract
Neurological
function
recovery
after
peripheral
nerve
injury
(PNI)
is
exceptionally
challenging,
chiefly
because
neurons
cannot
efficiently
proliferate,
differentiate,
and
form
regenerated
axons
to
pass
through
the
defect
region
expeditiously
transmit
neurological
signals.
In
this
study,
a
four‐dimensional
(4D)
oriented
dynamic
scaffold
constructed
based
on
shape
memory
polymer
(SMP),
which
can
regulate
spatiotemporally
controllable
neuronal
early
adequate
proliferation,
subsequently
effective
differentiation
axon
formation
by
synergizing
on‐demand
microtopography
deformation
force‐based
mechanical
stimuli
(DFMS).
This
accelerate
restoration
of
large
segmental
defects,
elevate
neural
signaling
efficiency
60%
compared
with
static
scaffold,
finally
functionalized
robust
regenerating
fascicles
comparable
therapeutic
effects
autologous
transplantation.
Furthermore,
crucial
role
Piezo1/Camk2b
modulated
extension
also
revealed
deep
transcriptomic
analysis.
summary,
4D
precisely
remotely
behavior
fate
in
non‐invasive
way,
has
excellent
potential
for
clinical
application
restoration.
