Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Human
cells,
such
as
fibroblasts
and
particularly
human
mesenchymal
stem
cells
(hMSCs),
represent
a
promising
effective
therapeutic
tool
for
range
of
cell-based
therapies
used
to
treat
various
diseases.
The
delivery
remains
challenge
due
limitations
in
targeting,
invasiveness,
cell
viability.
To
address
these
challenges,
we
developed
microneedle
(MN)
system
minimally
invasive
with
high
cellular
stability.
MN
comprises
core
gelatin
methacryloyl
(GelMA)
hydrogel
embedded
fibroblasts,
encased
polylactic-co-glycolic
acid
(PLGA)
shell
that
enhances
structural
integrity
efficient
skin
penetration.
fabrication
process
involves
UV-crosslinking
the
GelMA
optimizing
both
encapsulation
strength.
This
achieves
over
80%
viability
after
seven
days
vitro,
conventional
formulation
providing
superior
stability
outcomes.
platform's
ability
ensure
sustained
presents
implications
future
applications
regenerative
medicine,
wound
healing,
localized
treatments
conditions.
opens
new
avenues
therapies,
offering
versatile
scalable
solution
delivery.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
Acta Biomaterialia,
Год журнала:
2024,
Номер
184, С. 171 - 185
Опубликована: Июнь 12, 2024
Avoiding
ischemic
necrosis
after
flap
transplantation
remains
a
significant
clinical
challenge.
Developing
an
effective
pretreatment
method
to
promote
survival
postoperatively
is
crucial.
Cobalt
chloride
(CoCl
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Abstract
Live‐cell
therapy
has
emerged
as
a
revolutionary
treatment
modality,
providing
novel
therapeutic
avenue
for
intractable
diseases.
However,
major
challenge
in
live‐cell
is
to
maintain
viability
and
efficacy
during
the
treatment.
Microcarriers
are
crucial
enhancing
cell
retention,
viability,
functions
by
protective
scaffold
creating
supportive
environment
proliferation
metabolism.
For
microcarrier
construction,
microfluidic
technology
demonstrates
excellent
characteristics
terms
of
controllability
over
size
morphology
well
potential
high‐throughput
production.
To
date,
multiple
delivery
types
(e.g.,
microspheres,
microfibers,
microneedles)
prepared
via
liquid
templates
meet
different
needs.
In
this
review,
recent
developments
microfluidics‐based
microcarriers
presented.
It
focused
on
categorizing
structural
design
microfluidic‐derived
cell‐laden
microcarriers,
summarizing
various
applications.
Finally,
an
outlook
provided
future
challenges
opportunities
field.
