Microneedle-based cell delivery and cell sampling for biomedical applications DOI

Bricard Mbituyimana,

Manjila Adhikari,

Fuyu Qi

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 692 - 714

Published: Sept. 19, 2023

Language: Английский

Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing DOI
Chenguang Liu,

Ronger Ai,

Bi-zhi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140797 - 140797

Published: Feb. 7, 2025

Language: Английский

Citations

1
A Spatially Distributed Microneedle System for Bioorthogonal T Cell‐Guided Cancer Therapy DOI Creative Commons

Lanya Li,

Fei Wang, Shushan Mo

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Chimeric antigen receptor (CAR)-T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and poor infiltration CAR-T cells significantly hinder efficacy therapies against tumors. Here, spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate guide endogenous T tumors effective destruction. The SDMNS consists two dissolving microneedles, each loaded with complementary groups applied separately lymph nodes sites. One dibenzocyclooctyne (DBCO)-modified antibodies activates labels them in nodes. other microneedle, containing N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) glycometabolic labeling cells, chemotactic factor IP10, directly site. vivo studies demonstrate effectively directs migration activated into Through click reaction, DBCO-modified conjugate azide (N3)-modified eliciting robust antitumor immune responses durable memory. offers novel overcomes heterogeneity by facilitating directed cells.

Language: Английский

Citations

1
4D Oriented Dynamic Scaffold for Promoting Peripheral Nerve Regeneration and Functional Recovery DOI
Mouyuan Sun,

Dongqi You,

Ning Zhan

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(2)

Published: Sept. 12, 2023

Abstract Neurological function recovery after peripheral nerve injury (PNI) is exceptionally challenging, chiefly because neurons cannot efficiently proliferate, differentiate, and form regenerated axons to pass through the defect region expeditiously transmit neurological signals. In this study, a four‐dimensional (4D) oriented dynamic scaffold constructed based on shape memory polymer (SMP), which can regulate spatiotemporally controllable neuronal early adequate proliferation, subsequently effective differentiation axon formation by synergizing on‐demand microtopography deformation force‐based mechanical stimuli (DFMS). This accelerate restoration of large segmental defects, elevate neural signaling efficiency 60% compared with static scaffold, finally functionalized robust regenerating fascicles comparable therapeutic effects autologous transplantation. Furthermore, crucial role Piezo1/Camk2b modulated extension also revealed deep transcriptomic analysis. summary, 4D precisely remotely behavior fate in non‐invasive way, has excellent potential for clinical application restoration.

Language: Английский

Citations

20
Novel microneedle platforms for the treatment of wounds by drug delivery: A review DOI
Heng An, Zhen Gu, Zhe Huang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 233, P. 113636 - 113636

Published: Nov. 11, 2023

Language: Английский

Citations

20
Microneedle-based cell delivery and cell sampling for biomedical applications DOI

Bricard Mbituyimana,

Manjila Adhikari,

Fuyu Qi

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 692 - 714

Published: Sept. 19, 2023

Language: Английский

Citations

19