Acta Biomaterialia, Год журнала: 2023, Номер 162, С. 44 - 56
Опубликована: Март 17, 2023
Язык: Английский
Exploration, Год журнала: 2022, Номер 2(2)
Опубликована: Март 7, 2022
Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H
Язык: Английский
Процитировано
196
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Ноя. 24, 2023
Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.
Язык: Английский
Процитировано
119
Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 190, С. 114536 - 114536
Опубликована: Сен. 13, 2022
Язык: Английский
Процитировано
108
Advanced Materials, Год журнала: 2022, Номер 36(10)
Опубликована: Окт. 10, 2022
Multienzyme-mimicking redox nanozymes, curated by defect engineering, in synergy with immunotherapy offer promising prospects for safe and efficient cancer therapy. However, the spatiotemporally precise immune response often gets challenged off-target adverse effects insufficient therapeutic response. Herein, a tumor cell membrane coated nanozyme (CMO-R@4T1) is reported combinational second near-infrared window (NIR-II) photothermal immunotherapy. CMO-R@4T1 consists of Cu-doped MoO
Язык: Английский
Процитировано
88
Pharmaceuticals, Год журнала: 2023, Номер 16(2), С. 234 - 234
Опубликована: Фев. 3, 2023
Inducing cancer cell death has always been a research hotspot in life sciences. With the continuous deepening and diversification of related research, potential value metal elements inducing explored. Taking iron as an example, ferroptosis, mainly characterized by increasing load driving production large amounts lipid peroxides eventually leading to death, recently attracted great interest community. After iron, copper, trace element, received extensive attention especially tumor death. Copper its complexes can induce autophagy or apoptosis cells through variety different mechanisms action (activation stress pathways, arrest cycle, inhibition angiogenesis, cuproptosis, paraptosis), which are promising therapy have become new hotspots treatment research. This article reviews main applications novel copper compound-induced focusing on compounds their anticancer applications.
Язык: Английский
Процитировано
85
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 197, С. 114821 - 114821
Опубликована: Апрель 9, 2023
Язык: Английский
Процитировано
85
Chemical Engineering Journal, Год журнала: 2022, Номер 452, С. 138422 - 138422
Опубликована: Авг. 2, 2022
Язык: Английский
Процитировано
77
Advanced Materials, Год журнала: 2023, Номер 35(45)
Опубликована: Сен. 17, 2023
To improve the magnetic resonance imaging (MRI) efficiency and ferroptosis therapy efficacy of exceedingly small iron oxide nanoparticles (IO, <5 nm) for tumors via enhancing sensitivity tumor microenvironment (TME) responsiveness, inspired by molecular logic gates, a self-assembled IO with an AND gate function is designed constructed. Typically, cystamine (CA) conjugated onto end poly(2-methylthio-ethanol methacrylate) (PMEMA) to generate PMEMA-CA. The PMEMA-CA grafted surface brequinar (BQR)-loaded form IO-BQR@PMEMA. IO-BQR@PMEMA (SA-IO-BQR@PMEMA) obtained due hydrophobicity PMEMA. carbon-sulfur single bond can be oxidized reactive oxygen species (ROS) in TME thio-oxygen double bond, resulting conversion from being hydrophobic hydrophilic. disulfide broken glutathione (GSH) TME, leading shedding PMEMA surface. Under dual actions ROS GSH (i.e., gate), SA-IO-BQR@PMEMA disassembled release IO, Fe2+/3+ , BQR. In vitro vivo results demonstrate mechanism, high T1 MRI performance exceptional tumors, excellent biosafety SA-IO-BQR@PMEMA.
Язык: Английский
Процитировано
57
BMEMat, Год журнала: 2023, Номер 1(1)
Опубликована: Фев. 16, 2023
Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high specificity by responding TME (overexpressed hydrogen peroxide (H 2 O ) glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated can further enhance catalytic activity controllability treatment. In addition, other photo‐induced therapies, including photodynamic photothermal (PDT, PTT), may synergize with obtain boosting treatment efficacy avoid multidrug resistance. this minireview, we summarize recent advances photo‐assisted CDT, PTT‐facilitated PDT‐facilitated CDT. More importantly, challenges encountered process are discussed potential development directions suggested facilitate clinical translation future.
Язык: Английский
Процитировано
55
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(20)
Опубликована: Март 10, 2023
The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. However, such COFs are generally constructed using small-molecule photosensitizers. Herein, we report that the reticular chemistry-based synthesis from two inert monomers yields a COF-based sonosensitizer (TPE-NN) inherent activity. Subsequently, nanoscale COF TPE-NN fabricated and embedded copper (Cu)-coordinated sites to obtain TPE-NN-Cu. Results show Cu coordination can enhance effect TPE-NN, whereas ultrasound (US) irradiation for therapy augment chemodynamic efficacy Consequently, TPE-NN-Cu upon US shows high-performance anticancer based on mutually reinforced sono-/chemo-nanodynamic therapy. This study reveals backbone-originated activity proposes paradigm nanodynamic
Язык: Английский
Процитировано
55