Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(6), С. 449 - 467

Опубликована: Май 1, 2024

Язык: Английский

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J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

Advanced Materials, Год журнала: 2023, Номер 36(1)

Опубликована: Авг. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Язык: Английский

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Electrospun medicated gelatin/polycaprolactone Janus fibers for photothermal-chem combined therapy of liver cancer

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132113 - 132113

Опубликована: Май 6, 2024

Язык: Английский

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Coordination Chemistry Reviews, Год журнала: 2024, Номер 514, С. 215907 - 215907

Опубликована: Май 12, 2024

Язык: Английский

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Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Март 5, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher fidelity monitoring physiological and pathological processes than clinical visible/the fluorescence imaging. Notably, heavily dependent on agents. So far, indocyanine green, one polymethine dyes, with good biocompatibility renal clearance only dye approved by Food Drug Administration, but it shows relatively low NIR-II brightness. Importantly, tremendous efforts are devoted to synthesizing dyes for preclinically clinically. They have shown feasibility customization structure properties fulfill various needs therapy. Herein, a timely update special focus molecular design strategies fluorescent, photoacoustic, multimodal imaging, offered. Furthermore, progress sensing biomarkers even reporting drug release illustrated. Moreover, imaging-guided therapies summarized regarding chemo-, photothermal, photodynamic, approaches. In addition, artificial intelligence pointed out potential expedite development. This comprehensive review will inspire interest among wide audience offer handbook people an dyes.

Язык: Английский

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Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics

Coordination Chemistry Reviews, Год журнала: 2024, Номер 504, С. 215654 - 215654

Опубликована: Янв. 20, 2024

Язык: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122

Опубликована: Авг. 6, 2024

Язык: Английский

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Carrier-free nanoparticles for cancer theranostics with dual-mode magnetic resonance imaging/fluorescence imaging and combination photothermal and chemodynamic therapy

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125285 - 125285

Опубликована: Янв. 1, 2025

Язык: Английский

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An NIR Fluorescence Turn‐on and MRl Bimodal Probe for Concurrent Real‐time in vivo Sensing and Labeling of β‐Galactosidase

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(46)

Опубликована: Сен. 28, 2023

Abstract To realize sensing and labeling biomarkers is quite challenging in terms of designing multimodal imaging probes. In this study, we developed a novel β ‐galactosidase ( ‐gal) activated bimodal probe that combines near‐infrared (NIR) fluorescence magnetic resonance (MRI) to enable real‐time visualization activity living organisms. Upon ‐gal activation, Gal‐Cy‐Gd‐1 exhibits remarkable 42‐fold increase NIR intensity at 717 nm, allowing covalent adjacent target enzymes or proteins avoiding molecular escape promote accumulation the tumor site. This reaction enhances longitudinal relaxivity by approximately 1.9 times, facilitating high‐resolution MRI. The unique features precise live cells mice. probe's utilization aids identifying situ ovarian tumors, offering valuable assistance removal tissue during surgical procedures fusion MRI activation through self‐immobilizing provides robust approach for visualizing activity. Moreover, sets groundwork developing other activatable probes, vivo enzyme localization.

Язык: Английский

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