Small,
Journal Year:
2022,
Volume and Issue:
18(35)
Published: Aug. 3, 2022
Abstract
Because
of
the
insufficiency
hydrogen
peroxide,
relatively
low
rate
Fenton
reaction,
and
active
glutathione
(GSH)
peroxidase
4
(GPX4)
in
tumor
cells,
it
is
difficult
to
achieve
a
desirable
efficacy
ferroptosis
therapy
(FT)
for
tumors
based
on
nanomaterials.
Inspired
by
concept
“cyclotron”
physics,
this
study,
new
cycloacceleration
reactive
oxygen
species
(ROS)
generation
cells
realize
high‐performance
FT
proposed.
Typically,
magnetic
resonance
imaging
(MRI)
contrast
agent
dotted
core–shell
Fe
3
O
/Gd
2
hybrid
nanoparticles
(FGNPs)
prepared
exceedingly
small
iron
oxide
(ES‐MIONs).
Sorafenib
(SFN)
loaded
poly(ethylene
glycol)
methyl
ether‐poly(propylene
sulfide)‐NH
(mPEG‐PPS‐NH
)
grafted
surface
FGNP
generate
SA‐SFN‐FGNP
via
self‐assembly.
The
results
vitro
vivo
demonstrate
can
work
with
acidic
microenvironment
endosomal
conditions,
reaction
system
X
C
−
,
cyclic
reactions
resulting
specific
ROS
tumors.
very
high
longitudinal
relaxivity
(
r
1
33.43
mM
−1
s
3.0
T)
makes
sure
that
be
used
MRI‐guided
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 7, 2022
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Nov. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(2), P. 234 - 234
Published: Feb. 3, 2023
Inducing
cancer
cell
death
has
always
been
a
research
hotspot
in
life
sciences.
With
the
continuous
deepening
and
diversification
of
related
research,
potential
value
metal
elements
inducing
explored.
Taking
iron
as
an
example,
ferroptosis,
mainly
characterized
by
increasing
load
driving
production
large
amounts
lipid
peroxides
eventually
leading
to
death,
recently
attracted
great
interest
community.
After
iron,
copper,
trace
element,
received
extensive
attention
especially
tumor
death.
Copper
its
complexes
can
induce
autophagy
or
apoptosis
cells
through
variety
different
mechanisms
action
(activation
stress
pathways,
arrest
cycle,
inhibition
angiogenesis,
cuproptosis,
paraptosis),
which
are
promising
therapy
have
become
new
hotspots
treatment
research.
This
article
reviews
main
applications
novel
copper
compound-induced
focusing
on
compounds
their
anticancer
applications.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
36(10)
Published: Oct. 10, 2022
Multienzyme-mimicking
redox
nanozymes,
curated
by
defect
engineering,
in
synergy
with
immunotherapy
offer
promising
prospects
for
safe
and
efficient
cancer
therapy.
However,
the
spatiotemporally
precise
immune
response
often
gets
challenged
off-target
adverse
effects
insufficient
therapeutic
response.
Herein,
a
tumor
cell
membrane
coated
nanozyme
(CMO-R@4T1)
is
reported
combinational
second
near-infrared
window
(NIR-II)
photothermal
immunotherapy.
CMO-R@4T1
consists
of
Cu-doped
MoO
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(45)
Published: Sept. 17, 2023
To
improve
the
magnetic
resonance
imaging
(MRI)
efficiency
and
ferroptosis
therapy
efficacy
of
exceedingly
small
iron
oxide
nanoparticles
(IO,
<5
nm)
for
tumors
via
enhancing
sensitivity
tumor
microenvironment
(TME)
responsiveness,
inspired
by
molecular
logic
gates,
a
self-assembled
IO
with
an
AND
gate
function
is
designed
constructed.
Typically,
cystamine
(CA)
conjugated
onto
end
poly(2-methylthio-ethanol
methacrylate)
(PMEMA)
to
generate
PMEMA-CA.
The
PMEMA-CA
grafted
surface
brequinar
(BQR)-loaded
form
IO-BQR@PMEMA.
IO-BQR@PMEMA
(SA-IO-BQR@PMEMA)
obtained
due
hydrophobicity
PMEMA.
carbon-sulfur
single
bond
can
be
oxidized
reactive
oxygen
species
(ROS)
in
TME
thio-oxygen
double
bond,
resulting
conversion
from
being
hydrophobic
hydrophilic.
disulfide
broken
glutathione
(GSH)
TME,
leading
shedding
PMEMA
surface.
Under
dual
actions
ROS
GSH
(i.e.,
gate),
SA-IO-BQR@PMEMA
disassembled
release
IO,
Fe2+/3+
,
BQR.
In
vitro
vivo
results
demonstrate
mechanism,
high
T1
MRI
performance
exceptional
tumors,
excellent
biosafety
SA-IO-BQR@PMEMA.
Exploration,
Journal Year:
2023,
Volume and Issue:
4(2)
Published: Oct. 17, 2023
Abstract
The
emergence
of
drug‐resistant
bacteria
poses
a
significant
threat
to
people's
lives
and
health
as
bacterial
infections
continue
persist.
Currently,
antibiotic
therapy
remains
the
primary
approach
for
tackling
infections.
However,
escalating
rates
drug
resistance
coupled
with
lag
in
development
novel
drugs
have
led
diminishing
effectiveness
conventional
treatments.
Therefore,
nonantibiotic‐dependent
therapeutic
strategies
has
become
imperative
impede
rise
resistance.
chemodynamic
(CDT)
opened
up
new
possibility
due
CDT
can
convert
H
2
O
into
•OH
via
Fenton/Fenton‐like
reaction
treatment.
efficacy
is
limited
by
variety
practical
factors.
To
overcome
this
limitation,
sterilization
efficiency
be
enhanced
introducing
therapeutics
inherent
antimicrobial
capability.
In
addition,
researchers
explored
CDT‐based
combined
therapies
augment
its
effects
mitigate
potential
toxic
side
toward
normal
tissues.
This
review
examines
research
progress
field,
explores
various
enhance
presents
synergistic
combination
other
modalities.
And
last,
current
challenges
faced
future
directions
are
discussed.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 10, 2023
The
development
of
covalent
organic
framework
(COF)
sonosensitizers
with
intrinsic
sonodynamic
effects
is
highly
desirable.
However,
such
COFs
are
generally
constructed
using
small-molecule
photosensitizers.
Herein,
we
report
that
the
reticular
chemistry-based
synthesis
from
two
inert
monomers
yields
a
COF-based
sonosensitizer
(TPE-NN)
inherent
activity.
Subsequently,
nanoscale
COF
TPE-NN
fabricated
and
embedded
copper
(Cu)-coordinated
sites
to
obtain
TPE-NN-Cu.
Results
show
Cu
coordination
can
enhance
effect
TPE-NN,
whereas
ultrasound
(US)
irradiation
for
therapy
augment
chemodynamic
efficacy
Consequently,
TPE-NN-Cu
upon
US
shows
high-performance
anticancer
based
on
mutually
reinforced
sono-/chemo-nanodynamic
therapy.
This
study
reveals
backbone-originated
activity
proposes
paradigm
nanodynamic
