Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

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Aggregation‐Induced Emission‐Based Macrophage‐Like Nanoparticles for Targeted Photothermal Therapy and Virus Transmission Blockage in Monkeypox

Advanced Materials, Год журнала: 2023, Номер 36(9)

Опубликована: Ноя. 6, 2023

The recent prevalence of monkeypox has led to the declaration a Public Health Emergency International Concern. Monkeypox lesions are typically ulcers or pustules (containing high titers replication-competent virus) in skin and mucous membranes, which allow virus transmit predominantly through intimate contact. Currently, effective clinical treatments for lacking, strategies blocking transmission fraught with drawbacks. Herein, this work constructs biomimetic nanotemplate (termed TBD@M NPs) macrophage membranes as coat polymeric nanoparticles loading versatile aggregation-induced emission featured photothermal molecule TPE-BT-DPTQ core. In surrogate mouse model (vaccinia-virus-infected tail scarification model), intravenously injected NPs show precise tracking near-infrared region II fluorescence imaging lesions. Upon 808 nm laser irradiation, is eliminated by effect infected wound heals rapidly. More importantly, inoculation treated lesion tissue suspensions does not trigger infection inflammatory activation healthy mice, indicating successful blockage transmission. This study demonstrates first time theranostics using nanomedicine, may bring new insight into development viable strategy management trials.

Язык: Английский

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Biomimetic and bioinspired nano‐platforms for cancer vaccine development

Exploration, Год журнала: 2023, Номер 3(3)

Опубликована: Апрель 25, 2023

The advent of immunotherapy has revolutionized the treating modalities cancer. Cancer vaccine, aiming to harness host immune system induce a tumor-specific killing effect, holds great promises for its broad patient coverage, high safety, and combination potentials. Despite promising, clinical translation cancer vaccines faces obstacles including lack potency, limited options tumor antigens adjuvants, immunosuppressive microenvironment. Biomimetic bioinspired nanotechnology provides new impetus designing concepts vaccines. Through mimicking stealth coating, pathogen recognition pattern, tissue tropism pathogen, other irreplaceable properties from nature, biomimetic could gain functions such as longstanding, targeting, self-adjuvanting, on-demand cargo release. specific behavior endogenous molecules each type living entity (cell or microorganism) offer unique features address needs immunotherapy. In this review, strategies inspired by eukaryotic cells, bacteria, viruses will be overviewed advancing vaccine development. Our insights into future development shared at end expediting translation.

Язык: Английский

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Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 3, 2024

Abstract Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed a lipid bilayer membrane containing various biologically active cargoes such as proteins, lipids, nucleic acids. Engineered exosomes generated through genetic modification of parent show promise drug delivery vehicles, they have been demonstrated to great therapeutic potential for treating cancer, cardiovascular, neurological, immune diseases, but systematic knowledge is lacking regarding optimization loading assessment efficacy. This review summarizes current approaches engineering evaluating their effects, techniques assessing exosome release kinetics, cell targeting, biodistribution, pharmacokinetics, outcomes critically examined. Additionally, this synthesizes the latest applications in clinical translation. The compiled provides framework rational design rigorous therapeutics. Continued advancement robust characterization methods reporting standards will accelerate development technologies pave way studies. Graphical

Язык: Английский

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Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 22, 2025

Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared mono-treatment regimens. However, its use is associated drawbacks, such as insufficient reactive oxygen species (ROS) production and uneven photosensitizer distribution. To address these issues, we developed a controllable, targeted nanosystem that enhances oxidative stress through multiple pathways, achieving synergistic photothermal, photodynamic, immunotherapy for tumor treatment. These nanoparticles (D/I@HST NPs) accurately target overexpressed transferrin receptors (TfRs) on the surface of cells surface-modified (Tf). After endocytosis, D/I@HST NPs generate ROS under 808-nm laser irradiation, breaking ROS-responsive crosslinking agent increasing drug release utilization. Tf also carries Fe3+, reduced to Fe2+ by iron reductase in acidic microenvironment (TME). Consequently, endoperoxide bridge structure dihydroartemisinin cleaved, causing additional generation. Furthermore, released IR-780 exerts both photodynamic photothermal effects, enhancing cell death. This multi-pathway amplification effect can trigger immunogenic death tumors, promoting relevant antigens damage-associated molecular patterns, thereby dendritic maturation sensitivity immunotherapy. Mature transmit signals T cells, infiltration activation, facilitating growth inhibition suppression lung metastasis. myeloid-derived suppressor decreases after In summary, this stress-amplified effectively inhibits reverses immunosuppressive microenvironment, provides new insights into combined phototherapy.

Язык: Английский

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Oral Nanomedicine: Challenges and Opportunities

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Сен. 19, 2023

Abstract Compared to injection administration, oral administration is free of discomfort, wound infection, and complications has a higher compliance rate for patients with diverse diseases. However, reduces the bioavailability medicines, especially biologics (e.g., peptides, proteins, antibodies), due harsh gastrointestinal biological barriers. In this context, development prosperity nanotechnology have helped improve bioactivity availability medicines. On basis, first, barriers are discussed, then nanomedicine based on organic inorganic nanomaterials their biomedical applications in diseases reviewed. Finally, challenges potential opportunities future nanomedicine, which may provide vital reference eventual clinical transformation standardized production put forward.

Язык: Английский

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Nano-bio interactions in mRNA nanomedicine: Challenges and opportunities for targeted mRNA delivery

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115116 - 115116

Опубликована: Окт. 21, 2023

Язык: Английский

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EISA in Tandem with ICD to Form In Situ Nanofiber Vaccine for Enhanced Tumor Radioimmunotherapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(27)

Опубликована: Июнь 10, 2023

Radiotherapy (RT) can produce a vaccine effect and remodel tumor microenvironment (TME) by inducing immunogenic cell death (ICD) inflammation in tumors. However, RT alone is insufficient to elicit systemic antitumor immune response owing limited antigen presentation, immunosuppressive microenvironment, chronic within the tumor. Here, novel strategy reported for generation of situ peptide-based nanovaccines via enzyme-induced self-assembly (EISA) tandem with ICD. As ICD progresses, peptide Fbp-GD FD pY (Fbp-pY), dephosphorylated alkaline phosphatase (ALP) forms fibrous nanostructure around cells, resulting capture encapsulation autologous antigens produced radiation. Utilizing adjuvant controlled-release advantages self-assembling peptides, this nanofiber effectively increases accumulation lymph nodes cross-presentation antigen-presenting cells (APCs). In addition, inhibition cyclooxygenase 2 (COX-2) expression nanofibers promotes repolarization M2-macrophages into M1 reduces number regulatory T (Tregs) myeloid-derived suppressor (MDSCs) required TME remodeling. result, combination significantly enhances therapeutic on 4T1 tumors compared alone, suggesting promising treatment radioimmunotherapy.

Язык: Английский

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Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation

Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(8)

Опубликована: Май 31, 2024

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.

Язык: Английский

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A Mn²⁺‐Assisted Nanofiber‐Hydrogel Adjuvant for Simultaneous Enhancement of Humoral and Cellular Immune Responses

Advanced Functional Materials, Год журнала: 2024, Номер 34(30)

Опубликована: Апрель 9, 2024

Abstract Limited ability to elicit cellular immune responses has restricted the effectiveness of conventional adjuvants in context cancers. Recent advancements innate activation mechanism investigations have paved way for implementation a “bottom‐up” approach development novel adjuvants. Herein, simple hydrogel adjuvant with uniformly organized nanoscale microstructure, termed MnP gel is devised, by employing self‐assembling peptides incorporated manganese ions (Mn 2+ ). exhibits Mn sustained‐release properties vivo and effectively promotes germinal center formation, thereby facilitating generation antibodies at levels comparable aluminum‐based Moreover, transcends scope humoral immunity, demonstrating robustly trigger positioning it as promising candidate cancer prevention treatments. In conclusion, work introduced well‐defined proof‐of‐concept, simplifying vaccine design opening up new avenues “on‐demand” immunomodulation strategies.

Язык: Английский

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