Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216557 - 216557
Опубликована: Фев. 26, 2025
Язык: Английский
Acta Biomaterialia, Год журнала: 2024, Номер 177, С. 400 - 413
Опубликована: Фев. 8, 2024
Язык: Английский
Процитировано
15
Advanced Science, Год журнала: 2024, Номер 11(33)
Опубликована: Июль 1, 2024
In recent years, cancer immunotherapy has undergone a transformative shift toward personalized and targeted therapeutic strategies. Bacteria-derived outer membrane vesicles (OMVs) have emerged as promising adaptable platform for due to their unique properties, including natural immunogenicity the ability be engineered specific purposes. this review, comprehensive overview is provided of state-of-the-art techniques methodologies employed in engineering versatile OMVs immunotherapy. Beginning by exploring biogenesis composition OMVs, unveiling intrinsic immunogenic properties appeal. Subsequently, innovative approaches engineer are delved into, ranging from genetic parent bacteria incorporation functional molecules. The importance rational design strategies highlighted enhance specificity allowing tailoring diverse types. Furthermore, insights into clinical studies potential challenges utilizing vaccines or adjuvants also provided, offering assessment current landscape future prospects. Overall, review provides valuable researchers involved rapidly evolving field immunotherapy, roadmap harnessing full treatment.
Язык: Английский
Процитировано
13
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 16, 2024
Abstract Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer‐related death because immunosuppressive tumor microenvironment (TME) limits its therapeutic efficacy. Gasdermin (GSDM)‐mediated pyroptosis a new programmed cell that can boost antitumor immune responses. However, inducing efficient reverse TME challenging. Herein, layered double hydroxide‐coated magnesium (Zn‐LDH@Mg) implants are designed and constructed as alternating magnetic field (AMF)‐activated inducers induce highly effective in cancer cells. The powerful eddy‐thermal effects Zn‐LDH@Mg markedly amplify malignant cells through Caspase‐1/GSDMD‐dependent canonical pathway. Moreover, Mg 2+ synergistically activate T (especially CD8 + cells) enhance infiltration immune‐supportive This innovative strategy not only significantly suppresses proliferation primary but also stimulates response further efficacy checkpoint inhibitors impede progression distant tumors. work emphasizes importance surface engineering strategies for preparation novel highlights effectiveness reversing immunotherapy, providing approach rational design bioactive materials increase immunotherapy.
Язык: Английский
Процитировано
12
Materials Horizons, Год журнала: 2024, Номер 11(18), С. 4275 - 4310
Опубликована: Янв. 1, 2024
This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.
Язык: Английский
Процитировано
11
Nano TransMed, Год журнала: 2024, Номер 3, С. 100045 - 100045
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
11
Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216109 - 216109
Опубликована: Авг. 1, 2024
Immunotherapy is a promising strategy to inhibit the progression of solid tumors. However, current vaccine adjuvants represented by aluminum adjuvant (Alum) fail tumor antigens initiate effective T cell immunity. Despite efforts have been made optimize physical characteristics Alum, lack specific immunostimulatory functions still results in their inability effectively induce cytotoxic immune responses. Encouragingly, an iterative layered double hydroxide (LDH) nano‑aluminum (NanoAlum) re-engineered from clinical AlOOH Alum and Mg(OH)2 antacid has shown efficacy evoking both potent humoral cellular Notably, it can also serve as microenvironmental immunomodulator reshape aberrant physicochemical attributes microenvironment. Interestingly, highly flexible crystal structure chemical composition offer variety LDH-based candidates (NanoMAlum) doping with body essential nutritional metal ions (M), which show great potential amplify immunotherapy. In this review, we summarize development progress LDH NanoAlum its variants NanoMAlum for cancer By rethinking challenges that hindered preclinical/clinical application, charted research pathway based on engineered organoids accelerate applications these NanoMAlums review.
Язык: Английский
Процитировано
10
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Abstract Nanotheranostics, which integrate diagnostic and therapeutic functionalities, offer significant potential for tumor treatment. However, current nanotheranostic systems typically involve multiple molecules, each providing a singular or function, leading to challenges such as complex structural composition, poor targeting efficiency, lack of spatiotemporal control, dependence on single modality. This study introduces NP RBOXA , nanoparticle functionalized with surface‐bound cRGD targeted delivery α v β 3 /α 5 receptors cells, achieving theranostic integration by sequentially switching its irradiation modes. Under 808 nm laser irradiation, emits NIR‐II fluorescence, aids in identifying the nanoparticle's location fluorescence intensity, thereby determining optimal treatment window. Following this, mode switches ultrasound at Ultrasound induces generate reactive oxygen species, promoting reduction OXA‐IV OXA‐II, turn triggers immunogenic cell death. mechanism enables combination sonodynamic therapy, chemotherapy, immunotherapy The versatile design holds promise advancing precision oncology through enhanced efficacy real‐time imaging guidance.
Язык: Английский
Процитировано
10
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159226 - 159226
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Violet phosphorus (VP) is a allotrope first discovered by Hittorf in 1865, which has aroused more attention the biomedical field recent years attributed to its gradually unique properties. VP can be further categorized into bulk VP, nanosheets (VPNs), and quantum dots (VPQDs), chemical vapor transport (CVT), liquid‐phase/mechanical/laser exfoliation, solvothermal synthesis are common preparation approaches of VPNs, VPQDs, respectively. Compared with another (black phosphorus, BP) that once highly regarded applications, nanomaterial (namely VPNs VPQDs) not only exhibits tunable bandgap, moderate on/off current ratio, good biodegradability, but shows enhanced stability biosafety as well, allowing it promising candidate for variety applications like antibacterial therapy, anticancer biosensing disease diagnosis. In this review, classification relevant routes initially summarized, properties momentous subsequently expounded. The latest research advances emerging then introduced detail, both existing challenges future prospects also discussed.
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Enhancing the efficacy of glioma treatment poses a significant challenge. Ferroelectric nanomaterials, renowned for their remarkable piezoelectric properties, generate reactive oxygen species (ROS) when exposed to external stimuli or specific environmental conditions. This characteristic positions them as promising platforms highly effective cancer therapies. In this study, two‐dimensional (2D) black Bi 4 Ti 3 O 12 ferroelectric perovskite nanocatalysts with engineered vacancies are designed potent sources ROS efficient therapy. The band bending due polarization and narrowed bandgap induced by vacancy defects effectively enhance carrier separation, suppress recombination rates, markedly increase production. Moreover, mitochondrial dysfunction activation mitogen‐activated protein kinase (MAPK) pathways contribute favorable anti‐tumor effects. vitro cellular‐level assessments in vivo antineoplastic evaluations unequivocally demonstrate enhanced cytotoxicity tumor suppression enabled piezo‐catalytic strategy. research underscores role defect engineering optimizing effectiveness semiconductors catalytically inducing apoptosis cells.
Язык: Английский
Процитировано
2