Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Март 8, 2024
Pediatric
high-grade
gliomas
(pHGG)
are
a
rare
yet
devastating
malignancy
of
the
central
nervous
system’s
glial
support
cells,
affecting
children,
adolescents,
and
young
adults.
Tumors
system
account
for
leading
cause
pediatric
mortality
which
present
significantly
grim
prognosis.
While
past
few
decades
have
seen
many
cancers
experiencing
significant
improvements
in
overall
survival,
prospect
survival
patients
diagnosed
with
pHGGs
has
conversely
remained
unchanged.
This
can
be
attributed
part
to
tumor
heterogeneity
existence
blood-brain
barrier.
Advances
discovery
research
substantiated
unique
subgroups
displaying
alternate
responses
different
therapeutics
varying
degrees
survival.
highlights
necessity
approach
clinical
management
disease
an
alternative
subtype-dependent
manner.
review
covers
traditional
approaches
therapeutic
pHGGs,
limitations
such
methods
emerging
alternatives.
Novel
mutations
predominate
pHGG
landscape
highlighted
potential
targeting
them
subtype
specific
manner
discussed.
Collectively,
this
provides
insight
into
issues
need
transformative
progress
arise
during
pHGGs.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(14), С. 4672 - 4724
Опубликована: Янв. 1, 2023
This
review
discusses
the
strengths
and
shortcomings
of
different
strategies
to
facilitate
NP
transport
across
barriers
organs
highlights
key
findings
that
can
stimulate
further
advances
in
this
field.
Materials Today Bio,
Год журнала:
2023,
Номер
20, С. 100671 - 100671
Опубликована: Май 19, 2023
Gliomas
are
the
most
common
type
of
brain
cancer,
and
among
them,
glioblastoma
multiforme
(GBM)
is
prevalent
(about
60%
cases)
aggressive
primary
tumor.
The
treatment
GBM
a
major
challenge
due
to
pathophysiological
characteristics
disease,
such
as
presence
blood-brain
barrier
(BBB),
which
prevents
regulates
passage
substances
from
bloodstream
parenchyma,
making
many
chemotherapeutics
currently
available
not
able
reach
in
therapeutic
concentrations,
accumulating
non-target
organs,
causing
considerable
adverse
effects
for
patient.
In
this
scenario,
nanocarriers
emerge
tools
capable
improving
bioavailability
chemotherapeutics,
addition
their
biodistribution
enhancing
uptake
cells.
This
possible
its
nanometric
size
surface
modification
strategies,
can
actively
target
elements
overexpressed
by
cells
(such
transmembrane
receptors)
related
development,
drug
resistance,
poor
prognosis.
review,
an
overview
frequently
receptors
approaches
chemotherapeutic
delivery
active
targeting
using
will
be
presented.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Июль 5, 2023
At
present,
extracellular
vesicles
(EVs)
are
considered
key
candidates
for
cell-free
therapies,
including
treatment
of
allergic
and
autoimmune
diseases.
However,
their
therapeutic
effectiveness,
dependent
on
proper
targeting
to
the
desired
cells,
is
significantly
limited
due
reduced
bioavailability
resulting
from
rapid
clearance
by
cells
mononuclear
phagocyte
system
(MPS).
Thus,
developing
strategies
avoid
EV
elimination
essential
when
applying
them
in
clinical
practice.
On
other
hand,
malfunctioning
MPS
contributes
various
immune-related
pathologies.
Therapeutic
reversal
these
effects
with
EVs
would
be
beneficial
could
achieved,
example,
modulating
macrophage
phenotype
or
regulating
antigen
presentation
dendritic
cells.
Additionally,
intended
macrophages
replication
repackaging
molecules
into
new
vesicle
subtype
can
allow
specific
appropriate
populations
acceptor
Herein,
we
briefly
discuss
under-explored
aspects
MPS-EV
interactions
that
undoubtedly
require
further
research
order
accelerate
use
EVs.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(47)
Опубликована: Сен. 4, 2023
Abstract
Oxygen
as
one
of
the
most
critical
substances
in
living
organisms
has
attracted
ever‐increasing
attention
disease
treatment,
which
is
important
regulating
metabolic
activities.
However,
hypoxia
arising
from
a
prevalent
problem,
leading
to
observably
reduced
therapeutic
effectiveness
photodynamic
therapy,
radiotherapy,
sonodynamic
etc.
Therefore,
reversion
becomes
basis
for
enhancing
treatment.
Thanks
development
nanotechnology,
various
nanomaterials
with
oxygen‐production
capacity
are
explored
recover
function
oxygen
tissue,
but
there
still
some
limitations.
The
photosynthetic
microorganisms
(PSMs)
extensively
applied
improving
diseases
due
their
highly
efficient
photocatalytic
production
efficacy
and
desirable
biocompatibility.
In
this
review,
up‐to‐date
research
progress
on
modalities
microbial‐based
oxygenation
(e.g.,
cancer
wound
healing,
tissue
engineering)
summarized
highlighted.
addition,
key
issue
biocompatibility/biosafety
treatment
that
fundamental
apply
vivo
further
emphasized
clarified.
Finally,
present
issues
discussed
future
evolution
based
predicted,
promoting
clinical
applications.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Март 8, 2024
Pediatric
high-grade
gliomas
(pHGG)
are
a
rare
yet
devastating
malignancy
of
the
central
nervous
system’s
glial
support
cells,
affecting
children,
adolescents,
and
young
adults.
Tumors
system
account
for
leading
cause
pediatric
mortality
which
present
significantly
grim
prognosis.
While
past
few
decades
have
seen
many
cancers
experiencing
significant
improvements
in
overall
survival,
prospect
survival
patients
diagnosed
with
pHGGs
has
conversely
remained
unchanged.
This
can
be
attributed
part
to
tumor
heterogeneity
existence
blood-brain
barrier.
Advances
discovery
research
substantiated
unique
subgroups
displaying
alternate
responses
different
therapeutics
varying
degrees
survival.
highlights
necessity
approach
clinical
management
disease
an
alternative
subtype-dependent
manner.
review
covers
traditional
approaches
therapeutic
pHGGs,
limitations
such
methods
emerging
alternatives.
Novel
mutations
predominate
pHGG
landscape
highlighted
potential
targeting
them
subtype
specific
manner
discussed.
Collectively,
this
provides
insight
into
issues
need
transformative
progress
arise
during
pHGGs.
