Abstract
Oxidative
stress
results
from
an
imbalance
between
the
production
and
neutralization
of
reactive
oxygen
species.
It
induces
oxidative
damage
to
cellular
components
including
proteins,
lipids,
nucleic
acids,
membranes,
therefore
intrinsically
linking
aging‐related
diseases
such
as
cancer,
cardiovascular
disease,
neurological
disorders.
Emerging
evidence
suggests
that
may
promote
tumor
development
by
influencing
various
aspects
senescence,
its
onset,
pro‐inflammatory
secretion,
alteration
function
structure.
Modulating
target
senescence
offers
a
novel
strategy
for
cancer
prevention
treatment.
However,
thorough
grasp
specific
mechanisms
at
play
is
lacking.
This
review
will
present
association
their
regulatory
role
in
progression
treatment,
with
emphasis
on
senescence‐associated
secretory
phenotype,
immunosenescence
therapy‐induced
senescence.
Current
agents
strategies
remove
side
effects
via
killing
senescent
cells
or
modulating
improve
antitumor
efficacy
be
summarized.
help
readers
better
understand
complex
relationship
also
provide
basis
further
research
this
area.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 705 - 721
Опубликована: Янв. 1, 2025
The
metabolic
activity
of
tumor
cells
leads
to
the
acidification
surrounding
microenvironment,
which
provides
new
strategies
for
application
nanotechnology
in
cancer
therapy.Researchers
have
developed
various
types
pH-responsive
nanomaterials
based
on
acidic
microenvironment.This
review
an
in-depth
discussion
design
mechanisms,
drug-loading
strategies,
and
pathways
microenvironment-responsive
nanodrug
delivery
systems.These
materials
trigger
drug
release
upon
reaching
enhancing
therapeutic
targeting
reducing
toxicity
healthy
cells.pH-responsive
include
organic
nanomaterials,
inorganic
composite
nanomaterials.Additionally,
this
outlines
prospects,
challenges
aiming
promote
development
clinical
translation
field.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 17, 2024
Abstract
Bacteria
have
garnered
significant
attention
in
tumor
immunotherapy
recently
years,
owing
to
their
immune‐activating
properties,
ease
of
genetic
manipulation,
and
colonization
abilities.
In
order
further
enhance
the
safety,
efficacy,
clinical
translation
potential
bacterial
therapy,
endow
bacteria
with
additional
functions,
modifications
or
engineering
surfaces
emerged
as
a
current
research
hotspot.
This
review
systematically
summarizes
primary
methods
strategies
for
surface
modification
engineering,
including
chemical
alteration,
physical
modification,
bio‐modification.
Subsequently,
it
is
delve
into
roles
these
techniques
enhancing
immunotherapy,
such
improving
immunotherapeutic
efficacy
reducing
toxic
side
effects,
elucidate
underlying
mechanisms.
Finally,
challenges
faced
this
field
are
deeply
explored,
solutions
future
presented.
work
offers
comprehensive
overview
advancements
new
generation
implications
bacterial‐based
immunotherapy.
Abstract
Nanozyme‐mediated
chemodynamic
therapy
has
emerged
as
a
promising
strategy
due
to
its
tumor
specificity
and
controlled
catalytic
activity.
However,
the
poor
efficacy
caused
by
low
hydrogen
peroxide
(H
2
O
)
levels
in
microenvironment
(TME)
poses
challenges.
Herein,
an
H
self‐supplying
nanozyme
is
constructed
through
loading
peroxide‐like
active
platinum
nanoparticles
(Pt
NPs)
on
zinc
(ZnO
(denoted
ZnO
@Pt).
releases
response
acidic
TME.
Pt
NPs
catalyze
hydroxyl
radical
generation
from
while
reducing
mitigation
of
oxidative
stress
glutathione,
serving
reactive
oxygen
(ROS)
amplifier
self‐cascade
catalysis.
In
addition,
Zn
2+
released
interferes
with
cell
energy
supply
metabolism,
enabling
ion
interference
synergize
therapy.
vitro
studies
demonstrate
that
@Pt
induces
cellular
injury
enhanced
ROS
release,
downregulating
ATP
NAD
+
levels.
vivo
assessment
anticancer
effects
showed
could
generate
at
sites
induce
apoptosis
downregulate
pathways
associated
glycolysis,
resulting
89.7%
reduction
growth.
This
study
presents
TME‐responsive
capable
self‐supply
therapy,
providing
paradigm
for
tumor‐specific
design.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 27, 2024
Abstract
Engineered
Salmonella
has
emerged
as
a
promising
microbial
immunotherapy
against
tumors;
however,
its
clinical
effectiveness
encountered
limitations.
In
our
investigation,
we
unveil
non-dose-dependent
type
of
behavior
regarding
’s
therapeutic
impact
and
reveal
the
regulatory
role
neutrophils
in
diminishing
efficacy
this.
While
colonization
within
tumors
recruits
substantial
neutrophil
population,
these
predominantly
polarize
into
pro-tumor
N2
phenotype,
elevating
PD-L1
expression
fostering
an
immunosuppressive
milieu
tumor
microenvironment.
order
to
bypass
this
challenge,
introduce
MnO
2
nanoparticles
engineered
activate
STING
pathway.
Harnessing
pathway
stimulate
IFN-β
secretion
prompts
shift
polarization
from
N1
phenotype.
This
strategic
repolarization
remodels
immune
microenvironment,
making
infiltration
activation
CD8
+
T
cells
possible.
Through
orchestrated
mechanisms,
combined
employment
attains
synergistic
enhancement
anti-tumor
efficacy,
achieving
complete
inhibition
growth
20
days
impressive
80%
survival
rate
40
days,
with
no
discernible
signs
significant
adverse
effects.
Our
study
not
only
unveils
crucial
vivo
constraints
obstructing
therapy
but
also
sets
out
innovative
strategy
augment
efficacy.
These
findings
pave
way
for
advancements
cell-based
centered
on
leveraging
potential
neutrophils.
Graphical
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Tumor
vaccines
stand
at
the
vanguard
of
tumor
immunotherapy,
demonstrating
significant
potential
and
promise
in
recent
years.
While
have
achieved
breakthroughs
treatment
cancer,
they
still
encounter
numerous
challenges,
including
improving
immunogenicity
expanding
scope
vaccine
application.
As
natural
immune
activators,
bacterial
components
offer
inherent
advantages
vaccines.
Bacterial
membrane
components,
with
their
safer
profile,
easy
extraction,
purification,
engineering,
along
diverse
array
activate
system
improve
efficacy.
This
review
systematically
summarizes
mechanism
action
therapeutic
effects
membranes
its
derivatives
(including
vesicles
hybrid
biomaterials)
Subsequently,
authors
delve
into
preparation
based
on
biomaterials.
Following
this,
outer
are
elucidated,
mechanisms
explained.
Moreover,
combination
therapy
analyzed.
Last,
challenges
trends
this
field
discussed.
comprehensive
analysis
aims
to
a
more
informed
reference
scientific
foundation
for
design
implementation
membrane-based
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 14, 2024
Abstract
Tirapazamine
(TPZ),
an
antitumor
prodrug,
can
be
activated
in
hypoxic
environment.
It
specifically
targets
the
microenvironment
of
tumors
and
produces
toxic
free
radicals.
However,
due
to
tumor
is
not
completely
hypoxic,
TPZ
often
fails
effectively
treat
entire
tissue,
resulting
suboptimal
therapeutic
outcomes.
Herein,
a
low
pathogenic
Escherichia
coli
TOP10
utilized
selectively
colonize
tissues,
disrupt
blood
vessels,
induce
thrombus
formation,
leading
expansion
region
improving
effect
TPZ.
Additionally,
thermosensitive
hydrogel
constructed
by
Pluronic
F‐127
(F127),
which
undergoes
gelation
situ
at
site,
sustained
release
To
monitor
process,
it
genetically
modified
integrating
bioluminescent
system
luxCDABE
(TOP10‐Lux).
The
signal
associated
with
hypoxia
enhancement
beneficial
for
monitoring
bioluminescence
imaging.
In
murine
colon
cancer
model,
TOP10‐Lux
combined
TPZ‐loaded
F127
suppressed
growth,
treatment
process
efficiently
monitored.
Together,
this
work
employs
enhance
efficacy
providing
effective
strategy
bacteria‐based
tumor‐targeted
chemotherapy
monitoring.
With
the
comprehensive
understanding
of
microorganisms
and
rapid
advances
physiochemical
engineering
bioengineering
technologies,
scientists
are
advancing
rationally-engineered
bacteria
as
emerging
drugs
for
treating
various
diseases
in
clinical
disease
management.
Engineered
specifically
refer
to
advanced
or
genetic
technologies
combination
with
cutting
edge
nanotechnology
physical
which
have
been
validated
play
significant
roles
lysing
tumors,
regulating
immunity,
influencing
metabolic
pathways,
etc.
However,
there
has
no
specific
reviews
that
concurrently
cover
physiochemically-
genetically-engineered
their
derivatives
yet,
let
alone
distinctive
design
principles
functions
applications.
Herein,
applications
physiochemically
bacteria,
classify
discuss
breakthroughs
an
emphasis
on
methods
objective
different
uses
beyond
cancer
is
described.
The
combined
strategies
developing
vivo
biotherapeutic
agents
based
these
bacterial
derivatives,
elucidated
how
they
repress
other
also
underlined.
Additionally,
challenges
faced
by
translation
future
development
directions
discussed.
This
review
expected
provide
overall
impression
enlighten
more
researchers.
ACS Nano,
Год журнала:
2024,
Номер
18(46), С. 32103 - 32117
Опубликована: Ноя. 9, 2024
Pulmonary
delivery
of
anticancer
therapeutics
has
shown
encouraging
performance
in
treating
nonsmall
cell
lung
cancer
(NSCLC),
which
is
characterized
by
high
aggressiveness
and
poor
prognosis.
Cisplatin,
a
key
member
the
family
DNA
alkylating
agents,
extensively
employed
during
NSCLC
therapy.
However,
development
chemoresistance
occurrence
side
effects
severely
impede
long-term
application
cisplatin-based
chemotherapies.
Herein,
we
propose
meaningful
strategy
to
precisely
treat
cisplatin-resistant
based
on
combination
bioorthogonal
chemistry
with
an
inhalation
approach.
Ethacraplatin
(EA-Pt),
platinum
prodrug
(IV),
was
synthesized
encapsulated
nitric
oxide
(NO)-containing
micelles
overcome
cisplatin
chemoresistance.
By
further
modifying
molecules
this
nanoplatform
(EA-Pt@M
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 5, 2025
Purslane
(Portulaca
oleracea
L.)
with
heat-clearing
and
detoxicating,
anti-inflammatory
resolving
swelling,
relieving
itching
astringing
function,
has
remarkable
efficacy
for
acute
eczema.
However,
most
of
the
clinical
applications
purslane
are
freshly
prepared
decoction,
not
as
easy
to
apply
cream,
because
decoction
is
breed
bacteria
oxidize.
Here,
based
on
theory
Chinese
medicines
compatibility,
we
made
a
purslane-tannic
acid
hydrogel
(PL-HATA)
by
simple
methods
under
mild
conditions
solve
drawbacks
oxidation
inconvenience
use
Purslane.
The
antimicrobial
activity
PL-HATA
can
exert
an
excellent
effect,
reducing
flora
skin
eczema
further
symptoms
At
same
time,
it
creates
normal
reactive
oxygen
species
(ROS)
microenvironment
promotes
recovery
from
It
also
improves
promoting
cell
proliferation
migration.
Importantly,
resulted
in
improved
lesion
scores,
scratching
behavior,
eosinophil
infiltration,
swelling
inflammation
levels,
immune
homeostasis,
histopathological
changes
rats
Besides,
HATA
only
suitable
Purslane's
decocted
metabolites
but
squeezed
metabolites.
This
application
protocol
solved
its
storage
stability
convenience
use,
which
key
issue
promote
application.
