In Situ Forming, Enzyme-Responsive Peptoid-Peptide Hydrogels: An Advanced Long-Acting Injectable Drug Delivery System
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(31), С. 21401 - 21416
Опубликована: Июнь 26, 2024
Long-acting
drug
delivery
systems
are
promising
platforms
to
improve
patient
adherence
medication
by
delivering
drugs
over
sustained
periods
and
removing
the
need
for
patients
comply
with
oral
regimens.
This
research
paper
provides
a
proof-of-concept
development
of
new
optimized
in
situ
forming
injectable
depot
based
on
tetrabenzylamine-tetraglycine-d-lysine-O-phospho-d-tyrosine
peptoid-D-peptide
formulation
((NPhe)4GGGGk(AZT)y(p)-OH).
The
chemical
versatility
peptoid-peptide
motif
allows
low-molecular-weight
be
precisely
covalently
conjugated.
After
subcutaneous
injection,
hydrogel
forms
from
solubilized
peptoid-peptide-drug
response
phosphatase
enzymes
present
within
skin
space.
system
is
able
deliver
clinically
relevant
concentrations
model
drug,
antiretroviral
zidovudine
(AZT),
35
days
Sprague–Dawley
rats.
Oscillatory
rheology
demonstrated
that
formation
began
∼30
s,
an
important
characteristic
reducing
initial
bursts.
Gel
continued
up
∼90
min.
Small-angle
neutron
scattering
data
reveal
narrow-radius
fibers
(∼0.78–1.8
nm)
closely
fit
via
flexible
cylinder
elliptical
model.
inclusion
non-native
peptoid
monomers
D-variant
amino
acids
confers
protease
resistance,
enabling
enhanced
biostability
vitro.
Drug
release
proceeds
hydrolysis
ester
linkage
under
physiological
conditions,
releasing
unmodified
form
further
burst.
Subcutaneous
administration
(NPhe)4GGGGk(AZT)y(p)-OH
rats
resulted
blood
plasma
90%
maximal
inhibitory
concentration
(IC90)
range
(30–130
ng
mL–1)
days.
Язык: Английский
Peptide-based fluorescent Probes for the Diagnosis of Tumor and Image-Guided Surgery
M. S. Cai,
Zhuan Wen,
Hao-ze Li
и другие.
Biosensors and Bioelectronics,
Год журнала:
2025,
Номер
276, С. 117255 - 117255
Опубликована: Фев. 12, 2025
Язык: Английский
LA-peptide Hydrogel—Regulation of macrophage and fibroblast fates and their crosstalk via attenuating TGF-β to promote scarless wound healing
Bioactive Materials,
Год журнала:
2025,
Номер
47, С. 417 - 431
Опубликована: Фев. 12, 2025
Язык: Английский
Protein-induced silica coated PVDF membrane with long-term acid resistance and outstanding anti-oil-fouling performance for highly efficient separation of strongly acidic emulsion
Separation and Purification Technology,
Год журнала:
2025,
Номер
unknown, С. 131466 - 131466
Опубликована: Янв. 1, 2025
Язык: Английский
In situ self-assembled peptide nanoparticles improves anti-hepatic fibrosis effect
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Antagonistic
peptide
Leu-Ser-Lys-Leu
(LSKL)
is
capable
of
blocking
the
transforming
growth
factor-β1
(TGF-β1)
signaling
pathway
and
exhibits
anti-fibrotic
effects.
Herein,
we
constructed
LSKL
nanoparticles
(NPs)
in
situ
based
on
an
alkaline
phosphatase
(ALP)-instructed
self-assembly
strategy
for
improving
its
specific
therapeutic
effect
against
liver
fibrosis.
Язык: Английский
Skin-Adaptive Hydrogel Patch with Antitumor Activity for Tumor Elimination
ACS Applied Polymer Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Язык: Английский
Self-Assembly Regulated Photocatalysis of Porphyrin-TiO2 Nanocomposites
Molecules,
Год журнала:
2024,
Номер
29(16), С. 3872 - 3872
Опубликована: Авг. 15, 2024
Photoactive
artificial
nanocatalysts
that
mimic
natural
photoenergy
systems
can
yield
clean
and
renewable
energy.
However,
their
poor
photoabsorption
capability
disfavored
photogenic
electron-hole
recombination
hinder
production.
Herein,
we
designed
two
with
various
microstructures
by
combining
the
tailored
self-assembly
of
meso-tetra(p-hydroxyphenyl)
porphine
photosensitizer
growth
titanium
dioxide
(TiO
Язык: Английский
Injectable polypeptide-polysaccharide depot for preventing postoperative tumor recurrence by concurrent in situ chemotherapy and brachytherapy
Materials Today Bio,
Год журнала:
2024,
Номер
28, С. 101219 - 101219
Опубликована: Авг. 27, 2024
Chemotherapy
and
radiotherapy
in
combination
with
sequence
regimens
are
recognized
as
the
current
major
strategy
for
suppressing
postoperative
tumor
recurrence.
However,
systemic
side
effects
poor
in-field
cooperation
of
two
therapies
seriously
impair
therapeutic
efficacy
patients.
The
brachytherapy
chemotherapy
through
innovative
biomaterials
has
proven
to
be
an
important
achieve
synergistic
in-time
in-field.
chemoradiotherapy,
far
we
know,
there
few
relevant
reports.
Herein,
injectable
pH-responsive
polypeptide-polysaccharide
depot
concurrent
Язык: Английский