Injectable polypeptide-polysaccharide depot for preventing postoperative tumor recurrence by concurrent in situ chemotherapy and brachytherapy DOI Creative Commons
Jiaming Fan,

Xiaoyao Cai,

Han Gui

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101219 - 101219

Published: Aug. 27, 2024

Chemotherapy and radiotherapy in combination with sequence regimens are recognized as the current major strategy for suppressing postoperative tumor recurrence. However, systemic side effects poor in-field cooperation of two therapies seriously impair therapeutic efficacy patients. The brachytherapy chemotherapy through innovative biomaterials has proven to be an important achieve synergistic in-time in-field. chemoradiotherapy, far we know, there few relevant reports. Herein, injectable pH-responsive polypeptide-polysaccharide depot concurrent

Language: Английский

In Situ Forming, Enzyme-Responsive Peptoid-Peptide Hydrogels: An Advanced Long-Acting Injectable Drug Delivery System DOI Creative Commons

Sophie Coulter,

Sreekanth Pentlavalli,

Yuming An

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21401 - 21416

Published: June 26, 2024

Long-acting drug delivery systems are promising platforms to improve patient adherence medication by delivering drugs over sustained periods and removing the need for patients comply with oral regimens. This research paper provides a proof-of-concept development of new optimized in situ forming injectable depot based on tetrabenzylamine-tetraglycine-d-lysine-O-phospho-d-tyrosine peptoid-D-peptide formulation ((NPhe)4GGGGk(AZT)y(p)-OH). The chemical versatility peptoid-peptide motif allows low-molecular-weight be precisely covalently conjugated. After subcutaneous injection, hydrogel forms from solubilized peptoid-peptide-drug response phosphatase enzymes present within skin space. system is able deliver clinically relevant concentrations model drug, antiretroviral zidovudine (AZT), 35 days Sprague–Dawley rats. Oscillatory rheology demonstrated that formation began ∼30 s, an important characteristic reducing initial bursts. Gel continued up ∼90 min. Small-angle neutron scattering data reveal narrow-radius fibers (∼0.78–1.8 nm) closely fit via flexible cylinder elliptical model. inclusion non-native peptoid monomers D-variant amino acids confers protease resistance, enabling enhanced biostability vitro. Drug release proceeds hydrolysis ester linkage under physiological conditions, releasing unmodified form further burst. Subcutaneous administration (NPhe)4GGGGk(AZT)y(p)-OH rats resulted blood plasma 90% maximal inhibitory concentration (IC90) range (30–130 ng mL–1) days.

Language: Английский

Citations

17
Protein-induced silica coated PVDF membrane with long-term acid resistance and outstanding anti-oil-fouling performance for highly efficient separation of strongly acidic emulsion DOI
Feiyan Huang, Zhiwei Zhao, Zhiqin Yang

et al.

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 131466 - 131466

Published: Jan. 1, 2025

Language: Английский

Citations

0
Peptide-based fluorescent Probes for the Diagnosis of Tumor and Image-Guided Surgery DOI

M. S. Cai,

Zhuan Wen,

Hao-Ze Li

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 276, P. 117255 - 117255

Published: Feb. 12, 2025

Language: Английский

Citations

0
LA-peptide Hydrogel—Regulation of macrophage and fibroblast fates and their crosstalk via attenuating TGF-β to promote scarless wound healing DOI
Zichao Li, Leyang Zhang,

Yang Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 417 - 431

Published: Feb. 12, 2025

Language: Английский

Citations

0
In situ self-assembled peptide nanoparticles improves anti-hepatic fibrosis effect DOI

Wenbin Liu,

Beibei Wang,

Mengxing Wei

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Antagonistic peptide Leu-Ser-Lys-Leu (LSKL) is capable of blocking the transforming growth factor-β1 (TGF-β1) signaling pathway and exhibits anti-fibrotic effects. Herein, we constructed LSKL nanoparticles (NPs) in situ based on an alkaline phosphatase (ALP)-instructed self-assembly strategy for improving its specific therapeutic effect against liver fibrosis.

Language: Английский

Citations

0
Skin-Adaptive Hydrogel Patch with Antitumor Activity for Tumor Elimination DOI
Danting Li, Junxian Zhang, Jialin Zhang

et al.

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

Citations

0
Tumor-Specific Activated Polymeric Nanotuners Disrupt Positive Feedback Cycle of Hypoxia and Apoptosis Evasion for Potent Cancer Radiotherapy DOI

Xiaoxue Hou,

Chun Wang, Yu Zhao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123361 - 123361

Published: April 1, 2025

Language: Английский

Citations

0
Self-Assembly Regulated Photocatalysis of Porphyrin-TiO2 Nanocomposites DOI Creative Commons
Yi‐Sheng Liu,

Xinpeng Lv,

Yong Zhong

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3872 - 3872

Published: Aug. 15, 2024

Photoactive artificial nanocatalysts that mimic natural photoenergy systems can yield clean and renewable energy. However, their poor photoabsorption capability disfavored photogenic electron-hole recombination hinder production. Herein, we designed two with various microstructures by combining the tailored self-assembly of meso-tetra(p-hydroxyphenyl) porphine photosensitizer growth titanium dioxide (TiO

Language: Английский

Citations

1
Injectable polypeptide-polysaccharide depot for preventing postoperative tumor recurrence by concurrent in situ chemotherapy and brachytherapy DOI Creative Commons
Jiaming Fan,

Xiaoyao Cai,

Han Gui

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101219 - 101219

Published: Aug. 27, 2024

Chemotherapy and radiotherapy in combination with sequence regimens are recognized as the current major strategy for suppressing postoperative tumor recurrence. However, systemic side effects poor in-field cooperation of two therapies seriously impair therapeutic efficacy patients. The brachytherapy chemotherapy through innovative biomaterials has proven to be an important achieve synergistic in-time in-field. chemoradiotherapy, far we know, there few relevant reports. Herein, injectable pH-responsive polypeptide-polysaccharide depot concurrent

Language: Английский

Citations

1