Platinum–Iron Nanoparticles for Oxygen-Enhanced Sonodynamic Tumor Cell Suppression

Inorganics, Год журнала: 2024, Номер 12(12), С. 331 - 331

Опубликована: Дек. 18, 2024

A type of nanoparticle has been developed to simultaneously alleviate tumor hypoxia and enhance the effectiveness sonodynamic therapy aimed at improving cancer treatment outcomes. Small-sized iron–platinum nanoparticles were prepared using a thermal reduction method, their particle size crystal structure characterized. The ability these decompose hydrogen peroxide produce oxygen generate singlet under ultrasound irradiation was further tested. effect on inhibition proliferation MCF-7 cells hypoxic conditions also evaluated. effectively decomposed oxygen, reversing environment tumors. Additionally, they generated irradiation, which killed inhibited proliferation. This study successfully small-sized that can by decomposing excess in oxygen. Under inhibiting growth. demonstrated good safety are potentially valuable enhancing oxygen-enhanced therapy.

Язык: Английский

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Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.

Язык: Английский

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Metal‐Doping Strategy for Carbon‐Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 10, 2024

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) an innovative therapeutic approach that shows promise in elimination by activating sonosensitizers with low-intensity ultrasound. In this study, a novel sonosensitizer synthesized using Cu-doped carbon dots (Cu-CDs) sonodynamic treatment of GBM. Doping copper transforms into p-n type semiconductor having bandgap 1.58 eV, prolonged lifespan 10.7 µs, improved electron- hole-separation efficiency. The effect efficiency enhanced. Western blot analysis reveals Cu-CDs induces biological response leading to cell death, termed as cuproptosis. Specifically, upregulate dihydrosulfanyl transacetylase expression, thereby establishing synergistic against death when combined SDT. Furthermore, exhibit excellent permeability through blood-brain barrier potent anti-tumor activity. Importantly, effectively impede growth glioblastoma tumors prolong survival mice bearing these tumors. This study provides support application carbon-based nanomaterials therapy.

Язык: Английский

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Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Март 2, 2024

Abstract Surgical resection of bone tumors is the primary approach employed in treatment cancer. Simultaneously, perioperative interventions, particularly postoperative adjuvant anticancer strategies, play a crucial role achieving satisfactory therapeutic outcomes. However, occurrence tumor recurrence, metastasis, extensive defects, and infection are significant risks that can result unfavorable prognoses or even failure. In recent years, there has been progress development biomaterials, leading to emergence new options for therapy regeneration. This report aims comprehensively analyze strategic unique biomaterials with inherent healing properties bioactive capabilities tissue These composite classified into metallic, inorganic non‐metallic, organic types, thoroughly investigated their responses external stimuli such as light magnetic fields, internal interventions including chemotherapy catalytic therapy, combination well Additionally, an overview self‐healing materials osteogenesis provided potential applications combating osteosarcoma promoting formation explored. Furthermore, safety concerns integrated current limitations addressed, while also discussing challenges future prospects.

Язык: Английский

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Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition

Advanced Materials, Год журнала: 2024, Номер 36(45)

Опубликована: Сен. 3, 2024

Abstract Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form inflammatory programmed cell death, presents dependable strategy combating cancer by engaging multiple death pathways (apoptosis, pyroptosis, necroptosis). In this study, ultrasmall Bi 2 Sn O 7 nanozyme with ultrasound‐magnified multienzyme‐mimicking properties designed engineered as PANoptosis inducer through destroying mitochondrial function tumor cells enhancing intracellular accumulation toxic reactive oxygen species, finally triggering activation process. The role has been verified expression related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, 1, p‐MLKL, RIPK3. inclusion external ultrasonic irradiation significantly augments enzyodynamic efficiency. vitro in vivo antineoplastic efficacy, along inhibition lung metastasis, validate benefits ‐mediated pathway. This study not only elucidates intricate mechanisms underlying inducer, but also offers novel perspective treatment carcinoma.

Язык: Английский

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Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101495 - 101495

Опубликована: Янв. 15, 2025

Язык: Английский

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Facile synthesis of a hydrazone-based zinc(ii) complex for ferroptosis-augmented sonodynamic therapy

Chemical Science, Год журнала: 2024, Номер 15(26), С. 10027 - 10035

Опубликована: Янв. 1, 2024

This work reports a facilely synthesized zinc( ii ) complex based on hydrazone ligand for ferroptosis-augmented sonodynamic therapy.

Язык: Английский

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Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(25), С. 6091 - 6101

Опубликована: Янв. 1, 2024

Due to the rapid progression and aggressive metastasis of breast cancer, its diagnosis treatment remain a great challenge. The simultaneous inhibition tumor growth is necessary for cancer obtain ideal therapeutic outcomes. We herein report development radioactive hybrid semiconducting polymer nanoparticles (SPNH) imaging-guided tri-modal therapy cancer. Two polymers are used form SPNH with diameter around 60 nm via nano-coprecipitation they also labeled iodine-131 (131I) enhance imaging functions. formed show good radiolabeling stability excellent photodynamic photothermal effects under 808 laser irradiation produce singlet oxygen (1O2) heat. Moreover, can generate 1O2 ultrasound their sonodynamic properties. After intravenous tail vein injection, effectively accumulate in subcutaneous 4T1 tumors living mice as verified fluorescence single photon emission computed tomography (SPECT) imaging. With using an US, mediate (PDT), (PTT) (SDT) kill cells. Such leads improved efficacy inhibiting suppressing compared sole SDT combinational PDT-PTT. This study thus demonstrates applications diagnose combine different therapies effective treatment.

Язык: Английский

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Modulating the Electronic Structure of MnNi₂S₃ Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen‐Immunotherapy

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Hydrogen (H 2 ) therapy has demonstrated antitumor effect, but the therapeutic efficacy is restricted by low solubility and nontarget delivery of H . Electrolysis O electrocatalysts sustainably releases enormous amounts inspires precise for tumor therapy. Herein, manganese‐doped Ni S 3 nanoelectrodes (MnNi NEs) are designed electrocatalytic activation immunity to effectively potentiate ‐immunotherapy. atoms featuring empty 3d orbitals reduce initial energy barrier hydrogen evolution reaction (HER) promoting adsorption O. Moreover, Mn with different electronegativity modulate electronic structure facilitate desorption generated , thus enhancing HER activity MnNi NEs. Based on high activity, controllable (EHT) achieved in a voltage‐dependent manner. Mechanistically, NE‐mediated EHT induces mitochondrial dysfunction oxidative stress, which subsequently activates pyroptosis through typical ROS/caspase‐1/GSDMD signaling pathway. Furthermore, enhances infiltration CD8 + T lymphocytes into tumors reverses immunosuppressive microenvironment. This work demonstrates an electrocatalyst synergistic gas‐immunotherapy, may spark electrocatalyst‐based strategies.

Язык: Английский

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2D Black Ferroelectric Perovskite Nanocatalysts Enable Defect Modulation‐Augmented Piezocatalytic Glioma Therapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Enhancing the efficacy of glioma treatment poses a significant challenge. Ferroelectric nanomaterials, renowned for their remarkable piezoelectric properties, generate reactive oxygen species (ROS) when exposed to external stimuli or specific environmental conditions. This characteristic positions them as promising platforms highly effective cancer therapies. In this study, two‐dimensional (2D) black Bi 4 Ti 3 O 12 ferroelectric perovskite nanocatalysts with engineered vacancies are designed potent sources ROS efficient therapy. The band bending due polarization and narrowed bandgap induced by vacancy defects effectively enhance carrier separation, suppress recombination rates, markedly increase production. Moreover, mitochondrial dysfunction activation mitogen‐activated protein kinase (MAPK) pathways contribute favorable anti‐tumor effects. vitro cellular‐level assessments in vivo antineoplastic evaluations unequivocally demonstrate enhanced cytotoxicity tumor suppression enabled piezo‐catalytic strategy. research underscores role defect engineering optimizing effectiveness semiconductors catalytically inducing apoptosis cells.

Язык: Английский

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