Burns, Год журнала: 2025, Номер unknown, С. 107562 - 107562
Опубликована: Май 1, 2025
Язык: Английский
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Дек. 2, 2024
ABSTRACT Contagious diseases caused by different types of highly contagious pathogens, such as SARS‐CoV‐2, monkeypox virus, Mycobacterium tuberculosis , and human immunodeficiency could trigger global outbreaks bring a huge public health burden. Advanced diagnostic, therapeutic, preventive strategies are urgently needed to deal with the epidemic diseases. Aggregation‐induced emission (AIE) has emerged one promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, distinguishing aggregation‐enhanced fluorescence. As result, they offer effective for diagnosis, treatment, prevention This review systematically outlined latest research progress AIE‐based biomaterials mechanisms in The versatility AIE molecules, well efficient fluorescence potential innovative combat these challenges. Thanks recent advances materials science better understanding aggregation‐induced luminogens (AIEgens), AIEgens have great provide solutions detection, By reviewing state‐of‐the‐art methods killing, agents highlighting technological developments, this outlook aims promote development new means control emerging, re‐emerging, major further activities critical area research.
Язык: Английский
Процитировано
13
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140934 - 140934
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
2
International Journal of Pharmaceutics, Год журнала: 2025, Номер 672, С. 125336 - 125336
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 9, 2024
Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.
Язык: Английский
Процитировано
9
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 678 - 695
Опубликована: Янв. 24, 2025
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 106064 - 106064
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
6
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(20), С. 25856 - 25868
Опубликована: Май 10, 2024
Artificial peroxisomes (AP) with enzyme-mimetic catalytic activity and recruitment ability have drawn a great deal of attention in fabricating protocell systems for scavenging reactive oxygen species (ROS), modulating the inflammatory microenvironment, reprogramming macrophages, which is potential treating diseases such as rheumatoid arthritis (RA). Herein, macrophage membrane-cloaked Cu-coordinated polyphthalocyanine-based AP (CuAP) prepared macrocyclic conjugated polymerized network embedded Cu-single atomic active center, mimics coordination environment natural superoxide dismutase catalase, possesses performs photoacoustic imaging (PAI)-guided treatment. The results both vitro cellular vivo animal experiments demonstrated that CuAP under ultrasound microbubbles could efficiently scavenge excess ROS cells tissues, modulate microenvironmental cytokines interleukin-1β, tumor necrosis factor-α, arginase-1, reprogram macrophages by polarization M1 (proinflammatory phenotype) to M2 (anti-inflammatory phenotype). We believe this study offers proof concept engineering multifaceted promising approach PAI-guided treatment platform RA.
Язык: Английский
Процитировано
5
Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 653 - 676
Опубликована: Май 15, 2024
Язык: Английский
Процитировано
5
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 677, С. 632 - 644
Опубликована: Июль 27, 2024
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1228 - 1228
Опубликована: Сен. 20, 2024
Chimeric antigen receptor (CAR) T cell therapy has emerged as a groundbreaking treatment for hematological cancers, yet it faces significant hurdles, particularly regarding its efficacy in solid tumors and concerning associated adverse effects. This review provides comprehensive analysis of the advancements ongoing challenges CAR-T therapy. We highlight transformative potential nanotechnology enhancing by improving targeting precision, modulating immune-suppressive tumor microenvironment, overcoming physical barriers. Nanotechnology facilitates efficient CAR gene delivery into cells, boosting transfection efficiency potentially reducing costs. Moreover, offers innovative solutions to mitigate cytokine release syndrome (CRS) immune effector cell-associated neurotoxicity (ICANS). Cutting-edge platforms real-time monitoring activity are also discussed. By integrating these advancements, we aim provide valuable insights pave way next generation therapies overcome current limitations enhance therapeutic outcomes.
Язык: Английский
Процитировано
3