Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(31), С. 17572 - 17587
Опубликована: Июль 29, 2024
Contamination
of
crop
seeds
and
feed
with
Aspergillus
flavus
its
associated
aflatoxins
presents
a
significant
threat
to
human
animal
health
due
their
hepatotoxic
carcinogenic
properties.
To
address
this
challenge,
researchers
have
screened
for
potential
biological
control
agents
in
peanut
soil
pods.
This
study
identified
promising
candidate,
strain
the
nonpigmented
bacterium,
Achromobacter
xylosoxidans
ZJS2-1,
isolated
from
rhizosphere
Zhejiang
Province,
China,
exhibiting
notable
antifungal
antiaflatoxin
activities.
Further
investigations
demonstrated
that
ZJS2-1
active
substances
(ZAS)
effectively
inhibited
growth
at
MIC
60
μL/mL
nearly
suppressed
AFB1
production
by
99%.
Metabolomic
analysis
revealed
ZAS
significantly
affected
metabolites
involved
cell
wall
membrane
biosynthesis,
leading
compromised
cellular
integrity
induced
apoptosis
A.
through
release
cytochrome
c.
Notably,
targeted
SrbA,
key
transcription
factor
ergosterol
biosynthesis
integrity,
highlighting
crucial
role
ZJS2-1's
biocontrol
mechanism.
Moreover,
infection
plant
wilt
caused
can
be
efficiently
alleviated
ZAS.
Additionally,
inhibitory
effects
on
various
species,
inhibition
rates
ranging
80
These
findings
highlight
as
agent
against
offering
solution
enhance
food
safety
protect
health.
Plant Physiology and Biochemistry,
Год журнала:
2023,
Номер
196, С. 841 - 849
Опубликована: Фев. 27, 2023
The
mycotoxin
fusaric
acid
(FA)
induces
rapid
oxidative
burst
leading
to
cell
death
in
plants.
At
the
same
time,
plant
defence
reactions
are
mediated
by
several
phytohormones
for
instance
ethylene
(ET).
However,
previously
conducted
studies
leave
research
gaps
on
how
ET
plays
a
regulatory
role
under
exposure.
Therefore,
this
study
aims
time-dependent
effects
of
two
FA
concentrations
(0.1
mM
and
1
mM)
were
explored
regulation
reactive
oxygen
species
(ROS)
leaves
wild-type
(WT)
receptor
mutant
Never
ripe
(Nr)
tomatoes.
induced
superoxide
H2O2
accumulation
both
genotypes
dose-
exposure
pattern.
activated
NADPH
oxidase
(+34%
compared
control)
RBOH1
transcript
levels
WT
leaves.
production
was
significantly
higher
Nr
with
62%
which
could
contribute
lipid
peroxidation
genotype.
In
parallel,
antioxidative
mechanisms
also
activated.
Both
peroxidase
dismutase
activities
lower
but
ascorbate
showed
one-fold
activity
stress
than
Interestingly,
catalase
(CAT)
decreased
upon
time-
concentration-dependent
manner
encoding
CAT
genes
downregulated,
especially
at
20%.
Ascorbate
level
glutathione
remained
plants
Conclusively,
genotype
more
sensitivity
FA-induced
ROS
suggesting
that
serves
activating
enzymatic
non-enzymatic
antioxidants
detoxify
excess
accumulation.
Chronic
kidney
disease
(CKD)
is
a
growing
global
health
issue,
marked
by
high
mortality
rate
and
significant
cardiovascular
risks.
Despite
advancements
in
treatment,
definitive
cure
remains
out
of
reach,
as
current
approaches
mainly
focus
on
managing
underlying
conditions.
The
progression
CKD
largely
influenced
oxidative
stress,
fibrosis,
inflammation,
which
present
the
key
areas
for
therapeutic
intervention.
Natural
therapies
encompassing
plant
extracts
bioactive
molecules
have
been
promising
nephroprotective
action
due
to
their
anti-inflammatory,
diuretic,
antioxidative,
anti-fibrotic
properties.
immense
exploration
availability
drugs
management,
hurdles
remain
formulation
development
active
drug
delivery
these
phytoconstituents.
A
thoughtful
examination
properties
phytoconstituents
selection
developing
them
ideal
dosage
forms
can
reduce
gap
phytopharmaceuticals.
Consequently,
loaded
nanocarriers
hold
promise
safe
effective
at
site
produce
desired
outcomes.
Incorporating
natural
compounds
into
nanotechnology-based
systems
could
revolutionize
treatment
approaches.
Additionally,
understanding
biochemical
pathways
offers
opportunities
renal-specific
targeting
optimized
use
review
examines
potential
utilization
phytopharmaceuticals
suitable
occurrence
mechanisms,
that
be
considered
delivery.
Journal of Environmental Management,
Год журнала:
2025,
Номер
381, С. 125246 - 125246
Опубликована: Апрель 9, 2025
Food
contaminants
pose
serious
threats
to
public
health,
with
profound
negative
impacts
on
the
economy,
society,
and
environment.
However,
there
is
a
lack
of
timely
comprehensive
reviews
latest
developments
in
food
effective
measures
prevent
contamination,
particularly
through
novel
intelligent
detection
technologies
regulatory
regimes.
This
study
addresses
this
knowledge
gap
by
presenting
review
literature,
focusing
current
types
contaminants,
advances
technologies,
emerging
risks,
frameworks.
The
reviewed
116
relevant
articles
published
between
2019
2024
conducted
thematic
analysis.
were
classified
into
three
categories:
biological,
chemical,
physical.
identified
six
key
drivers
future
safety
risks:
demographic
change,
economic
factors,
environmental
conditions,
geopolitical
shifts,
consumer
priorities,
technological
advancements.
Findings
reveal
uneven
understanding
concern,
their
impact
system,
environment,
human
health.
These
findings
highlight
need
for
research
systematically
identifying
validating
regional
differences
contamination
prevention
assessing
extent
which
these
effectiveness
prevention,
mitigation,
control
efforts.
also
call
more
international
cooperation
active
involvement
technology
partners
facilitate
application
cutting-edge
control.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
Mycotoxins
are
toxic
substances
produced
as
byproducts
of
various
types
mold.
These
mycotoxins
mainly
linked
to
certain
genera
fungi,
such
Aspergillus,
Penicillium,
Fusarium,
Claviceps,
and
Alternaria,
formed
under
specific
conditions.
encompass
a
range
chemically
diverse
compounds
with
small
molecular
weight,
typically
less
than
1000
Da.
Currently,
more
500
recognized
harmful
the
health
humans,
animals,
plants.
Each
type
falls
into
particular
groups
distinct
effects,
most
common
well-known
ones
being
aflatoxins
(AFTs),
ochratoxins
(OTs),
fumonisins
(FUMs),
zearalenone
(ZEN),
trichothecenes
(TCTs),
patulin
(PAT),
citrinin
(CT).
Adhering
good
agricultural
industrial
practices
is
crucial
reducing
risk
mycotoxin
contamination
in
food
production.
Efficient
prompt
detection
utmost
importance
realm
safety.
This
chapter
deals
conventional
commercial
methods
for
from
past
present.
Open Life Sciences,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Abstract
The
abundant
and
renewable
resources
from
fruit
by-products
are
getting
emphasis
on
their
valorization.
These
may
contain
toxic
substances
due
to
factors
such
as
cultivation,
harvesting,
transportation,
preservation,
or
processing.
Hence,
presenting
scientific
overviews
of
the
toxicological
qualities
detoxification
trends
these
critical
for
implicating
possible
present
demand
valorization
requires
methodologies
any
toxicants
develop
healthier
products.
This
review
emphasized
fruits
which
maximum
global
production
occurred
in
2022.
In
this
review,
heavy
metals
(arsenic,
cadmium,
cobalt,
chromium,
nickel,
lead,
mercury),
mycotoxins,
toxicant
organic
compounds,
anti-nutritional
factors,
pesticide/fungicide
residues
selected
byproducts
were
discussed.
Current
reduce
during
emphasized.
Novel
functional
foods
valorized
future
perspectives
also
focused
review.
