Flavones and Related Compounds: Synthesis and Biological Activity

Molecules, Год журнала: 2023, Номер 28(18), С. 6528 - 6528

Опубликована: Сен. 8, 2023

This review focuses on the synthesis and biological activity of flavones their related flavonoidic compounds, namely flavonols aurones. Among activities natural synthetic aurones, anticancer, antioxidant, antimicrobial properties are highlighted detailed in this review. Starting from structures acting multiple anticancer targets (myricetin, genkwanin, other structurally compounds), new flavone analogs were recently designed evaluated for activity. The most representative compounds summarized Natural recognized (baicalein, luteolin, quercetol, apigenin, kaempferol, tricin) have been derivatized or modulated by chemical methods order to obtain effective derivatives with improved properties. promising agents systematically applied method aurones is based oxidative cyclization o-hydroxychalcones. Depending reaction conditions structure precursor, some cases, several products result simultaneously: flavones, flavanones, flavonols, Based literature data results obtained our research group, aim highlight as well routes products, such hydroxyflavones while considering that, practice, it difficult predict which main exclusive product o-hydroxychalcones under certain conditions.

Язык: Английский

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Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

Biomolecules, Год журнала: 2023, Номер 13(11), С. 1600 - 1600

Опубликована: Окт. 31, 2023

Aging is a natural and inescapable phenomenon characterized by progressive deterioration of physiological functions, leading to increased vulnerability chronic diseases death. With economic medical development, the elderly population gradually increasing, which poses great burden society, economy field. Thus, healthy aging has now become common aspiration among people over world. Accumulating evidence indicates that substances can mediate deteriorated processes are highly likely have potential prolong lifespan improve aging-associated diseases. Foods from sources full bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids vitamins. These compounds their derivatives been shown be able delay and/or diseases, thereby prolonging lifespan, via regulation various processes. Here, we summarize current understanding anti-aging activities vitamins food sources, modes action in delaying improving This will certainly provide reference for further research on effects sources.

Язык: Английский

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Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

World Journal of Gastroenterology, Год журнала: 2025, Номер 31(9)

Опубликована: Фев. 18, 2025

Runchangningshen paste (RCNSP) is a made of four medicinal and edible homologous Chinese medicine mixed with honey. It known for its ability to nourish yin blood as well loosen the bowel relieve constipation. The pathophysiology functional constipation (FC) associated reduction in mucin-2 (MUC2) secretion microbial dysbiosis. To investigate underlying mechanism RCNSP against FC through MUC2 gut mucosal microbiota. Ultra-performance liquid chromatography tandem mass spectrometry characterized composition elucidate material basis action. model was induced via loperamide gavage (16 mg/kg) twice daily 7 days. Applying defecation function gastrointestinal motility assess severity. Hematoxylin eosin Alcian blue-periodic acid-schiff staining analyzed colonic morphology. Transmission electron microscope used observe ultrastructure goblet cells (GCs). Immunofluorescence colocalization, quantitative PCR, western blot assessed impact on gene protein expression within NLRP6/autophagy pathway. 16S rDNA employed sequence contained 12 components potential laxative effects. enhanced function, accelerated motility, maintained integrity. treatment significantly increased GC abundance production while preserving ultrastructure. At molecular level, colocalized key regulatory proteins modulated mRNA expressions Through sequencing analysis, altered microbiota composition. Specifically, it beneficial bacterial strains reducing harmful ones. Simultaneously, reduced butyrate-producing bacteria like Proteobacteria, Enterobacteriaceae, Blautia, Eubacterium decreased hydrogen sulfide-producing species, such Prevotellaceae. also bile acid-inhibiting g_Eubacter_coprostanoligenes_group Erysipelotrichaceae increasing acid-producing Colidextribacter. Our findings suggested that ameliorated dual mechanism: stimulated by activating NLRP6 inflammasome-mediated autophagy

Язык: Английский

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PHYTOCHEMICAL STUDY AND ANTIMICROBIAL PROPERTIES OF FILMY FERN (HYMENOPHYLLUM IMBRICATUM BLUME)

International Journal of Applied Pharmaceutics, Год журнала: 2025, Номер unknown, С. 107 - 111

Опубликована: Фев. 24, 2025

Objective: The research aimed for phytochemical study and screening antimicrobial activities of filmy fern Hymenophyllum imbricatum Blume. Methods: Antimicrobial assay used agar diffusion method against several pathogenic bacteria: Staphylococcus aureus ATCC 25923, Escherichia coli 25922, Pseudomonas aeruginosa 27853, Salmonella typhimurium 14028, typhosa NCTC 786, Bacillus subtillis 6633, Enterococcus faecalis 29212, Micrococcus luteus 10240, typhi, epidermidis 12228, Streptococcus mutans 25175, Vibrio cholera Inaba Methicillin-Resistant (MRSA), the isolation silica column chromatography, purification by recrystallization, identification spectroscopic techniques (NMR, MS, UV-Vis, IR). Results: Two compounds have been isolated from aerial part Blume as 4-acetylphenyl ether (1) genkwanin-4”-O-β-glucopyranose (2). activity inhibition some human bacteria S. E. P. B. M. V. Inaba, (MRSA) was inhibited at concentrations ranging 0.6-10 µg/disc. Conclusion: Flavonoid glycoside dimer were Himenophyllum imbricatum; both showed lower in compared to ethyl acetate fraction, which obtained moderate all testing bacteria.

Язык: Английский

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Network pharmacology-based approach to investigate the molecular targets and molecular mechanisms of Rosmarinus officinalis L. for treating aging-related disorders

Biogerontology, Год журнала: 2024, Номер 25(5), С. 793 - 808

Опубликована: Июль 17, 2024

Язык: Английский

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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 10, 2025

Introduction Diabetes is a major health issue that has reached alarming levels worldwide. Although their effectiveness, the antidiabetic drugs have many side effects such as cardiovascular diseases, kidney failure, and hepatic complications. Many plant species of genus Salvia L. “Arabian desert sage” ( deserti ) should began to be focus phytochemical bioactivity studies. Methods The study aims investigate, first-ever, antihyperlipidemic leaf hydroethanolic extract S. deserti, an endemic rare subshrub from Arabian desert. A single intraperitoneal injection alloxan monohydrate (160 mg/kg) was used induce type-2 diabetes. Development diabetes confirmed by measuring blood glucose collected tail vein after 72 h injection. Oral administration extracts at 200 400 mg/kg for 14 days were tested on alloxan-induced diabetic mice animals divided into 6 groups each. identity phenolic compounds S . conducted through HPLC-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS) analyses. Results significantly decreased restored renal function reducing ALT, AST, ALP, GGT, LDH, urea creatinine. An improved lipid profile revealed reduced TC, TG LDL coupled with increased level HDL also observed. Moreover, treatment relieved oxidative stress (reduction MDA H 2 O activity antioxidant enzymes SOD, CAT GPx. presence several (derivatives ferulic, coumaric, caffeic acids, among other derivatives) could least in part explain obtained data empower use source bioactive ingredients antioxidant, properties. Discussion Our research unveiled potential effectively manage its associated dyslipidemia improving status, recovery liver functions presumably increasing insulin secretion sensitivity peripheral tissues insulin.

Язык: Английский

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Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Plants, Год журнала: 2023, Номер 12(22), С. 3873 - 3873

Опубликована: Ноя. 16, 2023

Quercus species have been widely used in traditional medicine, and recently, researchers’ attention has focused on galls of the genus as a source health-promoting phytochemicals. This review presents summary most recent findings phytochemistry bioactivity oak galls, following screening scientific papers published two relevant databases, PubMed Embase, between January 2018 June 2023. The are rich active compounds, mostly gallotannins phenolic acids. Due to these secondary metabolites, reviewed studies demonstrated wide range biological activities, including antioxidant anti-inflammatory actions, antimicrobial properties, tissue-protective effects, antitumor, anti-aging, hypoglycemic potential. Thus, promising natural matrix, be considered obtaining pharmaceutical cosmetic preparations anti-aging strategies and, together with medications, management age-related diseases. In further evaluations, valuable functional properties reported preclinical studies, should confirmed clinical that would also take into account potential health risks their use.

Язык: Английский

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Enrichment of Olive Oils with Natural Bioactive Compounds from Aromatic and Medicinal Herbs: Phytochemical Analysis and Antioxidant Potential

Molecules, Год журнала: 2024, Номер 29(5), С. 1141 - 1141

Опубликована: Март 4, 2024

Olive oil and herbs, two key components of the Mediterranean diet, are known for their beneficial effects on humans. In our study, we incorporated aromatic medicinal herbs into local monovarietal olive oils via maceration procedures enrichment. We identified herbal-derived ingredients that migrate to contribute positively total phenolic content functional properties, such as radical scavenging activity. Thus, characterized essential composition (GC-MS), determined antioxidant capacity additives virgin before after The herbal compounds were analyzed by LC-LTQ/Orbitrap HRMS. found infused with Origanum vulgare ssp. hirtum, Rosmarinus officinalis Salvia triloba obtained an increased content, approximately 1.3 3.4 times, in comparison untreated ones. Infusion S. led a significantly higher capacity. Rosmarinic acid, well glucosides, not due high polarity. contrast, aglycones diterpenes from R. migrated enriched oils, leading significant increase improvement free

Язык: Английский

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Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies

Nutrients, Год журнала: 2024, Номер 16(14), С. 2356 - 2356

Опубликована: Июль 20, 2024

Aging is a complex process and significant risk factor for chronic diseases. Menopause, component of aging in women, associated with several important cardiometabolic conditions including metabolic syndrome, osteoporosis, cardiovascular Menopausal women could benefit from preventative strategies that may decrease morbidity mortality improve their quality life. Vitamins D K are essential nutrients required bone health, immune function, reducing risks, yet synergistic effect less understood women. This the first comprehensive review to summarize evidence found randomized clinical trials beneficial effects vitamin co-treatment postmenopausal In our literature search across key electronic databases such as Cochrane, PubMed, Ovid, we identified 31 pertinent studies. Overall, findings indicate combined intake vitamins positively affect health emphasizing importance maintaining healthy diet rich vegetables fermented dairy products. Given challenges obtaining all necessary solely through diet, supplements recommended promote well-being.

Язык: Английский

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Identification of O-Methyltransferases Potentially Contributing to the Structural Diversity of 2-(2-Phenylethyl)chromones in Agarwood

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(23), С. 13297 - 13307

Опубликована: Июнь 3, 2024

2-(2-Phenylethyl)chromones (PECs) are the primary constituents responsible for promising pharmacological activities and unique fragrance of agarwood. However, O-methyltransferases (OMTs) involved in formation diverse methylated PECs have not been reported. In this study, we identified one Mg2+-dependent caffeoyl-CoA-OMT subfamily enzyme (AsOMT1) three caffeic acid-OMT enzymes (AsOMT2–4) from NaCl-treated Aquilaria sinensis calli. AsOMT1 only converts caffeoyl-CoA to feruloyl-CoA but also performs nonregioselective methylation at either 6-OH or 7-OH position 6,7-dihydroxy-PEC. On other hand, AsOMT2–4 preferentially utilizes as substrates produce structurally PECs. Additionally, accepts nonPEC-type such acid apigenin generate products. Protein structure prediction site-directed mutagenesis revealed that residues L313 I318 AsOMT3, well S292 F313 AsOMT4 determine distinct regioselectivity these two OMTs toward apigenin. These findings provide important biochemical evidence remarkable structural diversity

Язык: Английский

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