Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(11), С. 1656 - 1683
Опубликована: Май 20, 2024
The
objective
of
this
study
is
to
create
a
nanoemulgel
formulation
Ribociclib
(RIBO),
highly
selective
inhibitor
CDK4/6
through
the
utilization
spontaneous
emulsification
method.
An
experimental
investigation
was
conducted
construct
pseudo-ternary
phase
diagram
for
most
favourable
utilizing
rice
bran
oil,
which
known
its
diverse
anticancer
properties.
consisted
varying
combination
surfactant
and
as
co-surfactant
(Tween
80
Transcutol,
respectively)
referred
Smix
trials
were
optimized
get
desired
outcome.
nanoemulsion
(NE)
formulations
that
developed
exhibited
droplet
size
179.39
nm,
accompanied
with
PDI
0.211.
According
data
released
by
Opt-RIBO-NE,
it
can
be
inferred
Higuchi
model
had
fit
among
many
kinetics
models
considered.
results
indicate
use
nanogel
preparations
topical
delivery
RIBO
in
breast
cancer
therapy,
specifically
RIBO-NE-G,
viable.
This
supported
extended
release
RIBO,
appropriate
level
drug
permeation
observed
Opt-RIBO-NE-G.
Due
Rice
Bran
RIBO-NE-G
greater
antioxidant
activity,
indicating
effectiveness
antioxidants.
stability
over
period
three
months,
shelf
life.
Therefore,
proposes
an
may
enhance
efficacy
treatment
mitigate
occurrence
systemic
side
effects
patients,
compared
suspension
preparation
RIBO.
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2024,
Номер
8, С. 100529 - 100529
Опубликована: Июнь 20, 2024
Cellulose,
a
natural
linear
biopolymer
composed
of
hierarchically
arranged
cellulose
nanofibrils,
presents
compelling
avenue
for
sustainable
nanocellulose
synthesis
from
agricultural
by-products.
This
innovative
approach
both
mitigates
organic
waste
and
landfill
disposal
unlocks
the
latent
potential
nanocellulose,
transforming
residue
into
valuable
resources.
paradigm
shift
towards
sustainability
resonates
across
diverse
industrial
sectors,
particularly
in
biomedical
research
development.
In
recent
years,
remarkable
attributes
including
its
biocompatibility,
low
cytotoxicity,
exceptional
water-holding
capacity
cell
immobilization,
have
propelled
adoption
various
medical
applications.
From
drug
delivery
systems
to
wound
healing,
tissue
engineering,
antimicrobial
treatments,
has
emerged
as
versatile
biomaterial.
Moreover,
strategic
integration
composites
structural
functionalization
enable
customizing
properties
specific
functions,
further
expanding
utility.
comprehensive
review
explores
prominent
types
nanocellulose—including
nanocrystals,
microbial
or
bacterial
cellulose—elucidating
their
underscores
principles
underpinning
utilization
by
exploring
sources
derived
biowaste
processes
production.
As
crucial
component
wide
array
materials,
drives
innovation
propels
advancement
biomedicine
toward
sustainability.
Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2361 - 2361
Опубликована: Сен. 21, 2023
Nanoformulations
have
become
increasingly
useful
as
drug
delivery
technologies
in
recent
decades.
As
therapeutics,
oral
administration
is
the
most
common
method,
although
it
not
always
effective
route
because
of
challenges
with
swallowing,
gastrointestinal
discomfort,
low
solubility,
and
poor
absorption.
One
significant
barriers
that
medications
must
overcome
to
exert
a
therapeutic
effect
impact
first
hepatic
transit.
Studies
shown
controlled-release
systems
using
nanoparticles
composed
biodegradable
natural
polymers
significantly
improve
administration,
which
why
these
materials
attracted
attention.
Chitosan
possesses
wide
variety
properties
functions
pharmaceutical
well
healthcare
industries.
Drug
encapsulation
transport
within
body
are
two
its
important
features.
Moreover,
chitosan
can
enhance
efficacy
by
facilitating
interaction
target
cells.
Based
on
physicochemical
properties,
potentially
be
synthesized
into
nanoparticles,
this
review
summarizes
advances
applications
orally
delivered
nanoparticle
interventions.
Journal of drug targeting,
Год журнала:
2024,
Номер
32(6), С. 655 - 671
Опубликована: Апрель 23, 2024
Oral
route
of
drug
administration
is
typically
the
initial
option
for
because
it
both
practical
and
affordable.
However,
major
drawback
this
includes
release
at
a
specified
place
thus
reduces
bioavailability.
This
could
be
overcome
by
utilising
gastroretentive
delivery
system
(GRRDS).
Prolonged
stomach
retention
improves
bioavailability
increases
solubility
medicines
that
are
unable
to
dissolve
in
high
pH
environments.
Many
recent
advancements
floating,
bio
adhesive,
magnetic,
expandable,
raft
forming
ion
exchange
systems
have
been
made
had
led
towards
advanced
form
delivery.
From
past
few
years,
floating
has
most
commonly
utilised
delayed
manner.
Various
polymers
manufacturing
these
systems,
including
alginates,
chitosan,
pectin,
carrageenan's,
xanthan
gum,
hydroxypropyl
cellulose,
carbomer,
polyethylene
oxide
sodium
carboxy
methyl
cellulose.
Chitosan,
pectin
gum
found
used
inclusion
complex
study
aimed
define
various
types
as
well
also
highlights
advances
future
perspectives
system.
Pharmaceutics,
Год журнала:
2024,
Номер
16(5), С. 670 - 670
Опубликована: Май 16, 2024
In
recent
years,
biopolymer-based
nano-drug
delivery
systems
with
antioxidative
properties
have
gained
significant
attention
in
the
field
of
pharmaceutical
research.
These
offer
promising
strategies
for
targeted
and
controlled
drug
while
also
providing
antioxidant
effects
that
can
mitigate
oxidative
stress-related
diseases.
Generally,
healthcare
landscape
is
constantly
evolving,
necessitating
continual
development
innovative
therapeutic
approaches
(DDSs).
DDSs
play
a
pivotal
role
enhancing
treatment
efficacy,
minimizing
adverse
effects,
optimizing
patient
compliance.
Among
these,
nanotechnology-driven
garnered
due
to
their
unique
properties,
such
as
improved
solubility,
release,
delivery.
Nanomaterials,
including
nanoparticles,
nanocapsules,
nanotubes,
etc.,
versatile
platforms
tissue
engineering
applications.
Additionally,
hold
immense
promise,
leveraging
natural
or
synthetic
biopolymers
encapsulate
drugs
enable
release.
numerous
advantages,
biocompatibility,
biodegradability,
low
immunogenicity.
The
utilization
polysaccharides,
polynucleotides,
proteins,
polyesters
biopolymer
matrices
further
enhances
versatility
applicability
DDSs.
Moreover,
substances
emerged
key
players
combating
diseases,
offering
protection
against
cellular
damage
chronic
illnesses.
nanoformulations
represents
burgeoning
research
area,
substantial
increase
publications
years.
This
review
provides
comprehensive
overview
developments
within
this
area
over
past
five
It
discusses
various
materials,
fabrication
techniques,
stabilizers,
factors
influencing
degradation,
it
highlights
emerging
trends,
challenges,
prospects
rapidly
evolving
field.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(31), С. 17138 - 17152
Опубликована: Июль 23, 2024
Chitin
and
chitosan
are
mostly
derived
from
the
exoskeletons
of
crustaceans,
insects,
fungi.
is
second
most
abundant
biopolymer
after
cellulose,
it
a
fibrous
polysaccharide
which
resists
enzymatic
degradation
in
stomach
but
undergoes
microbial
fermentation
colon,
producing
beneficial
metabolites.
Chitosan,
more
soluble
alkaline
small
intestine,
susceptible
to
action.
Both
biopolymers
show
limited
absorption
into
bloodstream,
with
smaller
particles
exhibiting
better
bioavailability.
The
health
effects
include
anti-inflammatory
properties,
potential
immune
system
modulation,
impacts
on
cholesterol
levels,
antimicrobial
effects,
specific
focus
implications
for
gut
health.
exhibit
properties
by
interacting
cells,
influencing
cytokine
production,
modulating
responses,
may
benefit
conditions
characterized
chronic
inflammation.
These
can
impact
levels
binding
dietary
fats
reducing
lipid
absorption.
Additionally,
their
contribute
controlling
harmful
pathogens
promoting
microbiota.
This
review
explores
extensive
benefits
applications
chitin
chitosan,
providing
detailed
examination
chemical
compositions,
sources,
applications,
critically
assessing
health-promoting
context
human
well-being.
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42739 - e42739
Опубликована: Фев. 1, 2025
This
review
explores
the
synergistic
potential
of
natural
products
and
nanotechnology
for
viral
infections,
highlighting
key
antiviral,
immunomodulatory,
antioxidant
properties
to
combat
pandemics
caused
by
highly
infectious
viruses.
These
often
result
in
severe
public
health
crises,
particularly
affecting
vulnerable
populations
due
respiratory
complications
increased
mortality
rates.
A
cytokine
storm
is
initiated
when
an
overload
pro-inflammatory
cytokines
chemokines
released,
leading
a
systemic
inflammatory
response.
Viral
mutations
limited
availability
effective
drugs,
vaccines,
therapies
contribute
continuous
transmission
virus.
The
coronavirus
disease-19
(COVID-19)
pandemic
has
sparked
renewed
interest
product-derived
antivirals.
efficacy
traditional
medicines
against
infections
examined.
Their
anti-inflammatory,
are
highlighted.
discusses
how
enhances
herbal
combating
infections.
